Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Khalid Hamid El Hachimi"'
Autor:
Susana Boluda, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Albert Cao, Clovis Adam, Alexandre Androuin, Franck Bielle, Guy Brochier, Frédéric Charlotte, Lydia Chougar, Khalid Hamid El Hachimi, Marc Eloit, Stéphane Haïk, Dominique Hervé, Amal Kasri, Valentin Leducq, Stéphane Lehéricy, Etienne Levavasseur, Christian Lobsiger, Geoffroy Lorin de La Grandmaison, Isabelle Malet, Isabelle Malissin, Stéphane Marot, Serge Marty, Philippe Pérot, Isabelle Plu, Annick Prigent, Lev Stimmer, Marie-Claude Potier, Anne-Geneviève Marcelin, Benoît Delatour, Charles Duyckaerts, Danielle Seilhean
Publikováno v:
Free Neuropathology, Vol 4 (2023)
In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative of small a
Externí odkaz:
https://doaj.org/article/05edf363d5d14e9389cc5d0000462bdb
Autor:
Maxime Boutry, Julien Branchu, Céline Lustremant, Claire Pujol, Julie Pernelle, Raphaël Matusiak, Alexandre Seyer, Marion Poirel, Emeline Chu-Van, Alexandre Pierga, Kostantin Dobrenis, Jean-Philippe Puech, Catherine Caillaud, Alexandra Durr, Alexis Brice, Benoit Colsch, Fanny Mochel, Khalid Hamid El Hachimi, Giovanni Stevanin, Frédéric Darios
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3813-3826 (2018)
Summary: Lysosome membrane recycling occurs at the end of the autophagic pathway and requires proteins that are mostly encoded by genes mutated in neurodegenerative diseases. However, its implication in neuronal death is still unclear. Here, we show
Externí odkaz:
https://doaj.org/article/358623cb25c54ed8bb5c4530b6f112e8
Autor:
Julien Branchu, Maxime Boutry, Laura Sourd, Marine Depp, Céline Leone, Alexandrine Corriger, Maeva Vallucci, Typhaine Esteves, Raphaël Matusiak, Magali Dumont, Marie-Paule Muriel, Filippo M. Santorelli, Alexis Brice, Khalid Hamid El Hachimi, Giovanni Stevanin, Frédéric Darios
Publikováno v:
Neurobiology of Disease, Vol 102, Iss , Pp 21-37 (2017)
Mutations in SPG11 account for the most common form of autosomal recessive hereditary spastic paraplegia (HSP), characterized by a gait disorder associated with various brain alterations. Mutations in the same gene are also responsible for rare forms
Externí odkaz:
https://doaj.org/article/b023231a3e9b4f1bb3ba9efcc036c289
Autor:
Amandine Duchesne, Anne Vaiman, Magali Frah, Sandrine Floriot, Sabrina Legoueix-Rodriguez, Anne Desmazières, Sébastien Fritz, Christian Beauvallet, Olivier Albaric, Eric Venot, Maud Bertaud, Romain Saintilan, Raphaël Guatteo, Diane Esquerré, Julien Branchu, Anaïs Fleming, Alexis Brice, Frédéric Darios, Jean-Luc Vilotte, Giovanni Stevanin, Didier Boichard, Khalid Hamid El Hachimi
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007550 (2018)
Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous human neurodegenerative diseases. Amongst the identified genetic causes, mutations in genes encoding motor proteins such as kinesins have been involved in various HSP
Externí odkaz:
https://doaj.org/article/19f03c95bd66498a8b31753d5b4988c1
Autor:
Manon Fortier, Margaux Cauhapé, Suzie Buono, Julien Becker, Alexia Menuet, Julien Branchu, Ivana Ricca, Serena Mero, Karim Dorgham, Khalid-Hamid El Hachimi, Kostantin Dobrenis, Benoit Colsch, Dominic Samaroo, Morgan Devaux, Alexandra Durr, Giovanni Stevanin, Filippo M. Santorelli, Sophie Colombo, Belinda Cowling, Frédéric Darios
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106564- (2024)
Biallelic variants in the SPG11 gene account for the most common form of autosomal recessive hereditary spastic paraplegia characterized by motor and cognitive impairment, with currently no therapeutic option. We previously observed in a Spg11 knocko
Externí odkaz:
https://doaj.org/article/dbf32e1bf6a942ce85d9572665e8edf3
Autor:
Livia Parodi, Khalid Hamid El Hachimi, Stéphane Zuily, Marine Legendre, Diana Rodriguez, Dario Saracino, Aleksandra Trifunovic, Silvina Perin, Nicolas Villain, Marijana Croon, Thierry Kuntzer, Mahmoud Y. Issa, Fanny Mochel, Filippo M. Santorelli, Foudil Lamari, Priscilla Thomas, Cyril Goizet, Chantal Tse, Claire Ewenczyk, Florence Fellmann, Maha S. Zaki, Arnaud Mourier, Patrick Giavalisco, Laurent Le Corre, Aurélien Trimouille, Emilie Blond, Milica Popovic, Frédéric Darios, Anastasia D. Gazi, Cyril Mignot, Isabelle Kemlin, Sophie M. Steculorum, Cécilia Marelli-Tosi, Joseph G. Gleeson, Mathilde Renaud, Claire Pujol, Jean-Luc Boucher, S. Mathieu, Shahira Elshafie, Anne Legrand, Serge Picaud, Alexandra Durr, Giulia Coarelli, Giovanni Stevanin, Manon Valet, Daniele Galatolo, Rana Alkouri, Alexandre Seyer
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩
J Exp Med
Journal of Experimental Medicine, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩
J Exp Med
Journal of Experimental Medicine, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩
International audience; Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenicmechanisms remains sparse, and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469946ff71d85dcc23b62485c5694fca
https://hal-pasteur.archives-ouvertes.fr/pasteur-03434224
https://hal-pasteur.archives-ouvertes.fr/pasteur-03434224
Autor:
Brigitte Potier, Manon Thierry, Benoît Delatour, Alexandre Androuin, Daniel Cattaert, Patrick Dutar, Charles Duyckaerts, Serge Marty, Khalid Hamid El Hachimi, Antoine Triller, Lydia Danglot, U. Valentin Nägerl, Ihsen Youssef
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 135 (6), pp.839-854. ⟨10.1007/s00401-018-1847-6⟩
Acta Neuropathologica, Springer Verlag, 2018, 135 (6), pp.839-854. ⟨10.1007/s00401-018-1847-6⟩
International audience; Alzheimer's disease (AD) is associated with a progressive loss of synapses and neurons. Studies in animal models indicate that morphological alterations of dendritic spines precede synapse loss, increasing the proportion of la
Autor:
Raphaël Guatteo, Diane Esquerre, Sabrina Legoueix-Rodriguez, Maud Bertaud, Anaïs Fleming, Julien Branchu, Christian Beauvallet, Romain Saintilan, Alexis Brice, Amandine Duchesne, Anne Vaiman, Frédéric Darios, Anne Desmazières, Giovanni Stevanin, Sandrine Floriot, Magali Frah, Olivier Albaric, Eric Venot, Khalid Hamid El Hachimi, Sébastien Fritz, Jean-Luc Vilotte, Didier Boichard
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
Plos Genetics 8 (14), 1-25. (2018)
PLoS Genetics, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
PLoS Genetics, Vol 14, Iss 8, p e1007550 (2018)
PLoS Genetics, Public Library of Science, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
Plos Genetics 8 (14), 1-25. (2018)
PLoS Genetics, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
PLoS Genetics, Vol 14, Iss 8, p e1007550 (2018)
Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous human neurodegenerative diseases. Amongst the identified genetic causes, mutations in genes encoding motor proteins such as kinesins have been involved in various HSP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ecf5137fe6992d8957c0ab7e85fc4
https://hal.inrae.fr/hal-02624522
https://hal.inrae.fr/hal-02624522
Autor:
Annie Sittler, Sandro Alves, Alexis Brice, Martine Barkats, Béatrice Dufresnois, Jean-Gabriel Dornbierer, Alexandre Janer, Christelle Tesson, Darren P. Baker, Morwena Latouche, Merle Ruberg, Martina Marinello, Giovanni Stevanin, Khalid Hamid El Hachimi, Alice Chort
Publikováno v:
Brain. 136:1732-1745
We showed previously, in a cell model of spinocerebellar ataxia 7, that interferon beta induces the expression of PML protein and the formation of PML protein nuclear bodies that degrade mutant ataxin 7, suggesting that the cytokine, used to treat mu
Autor:
Martina Marinello, Giovanni Stevanin, Khalid Hamid El Hachimi, Annie Sittler, Merle Ruberg, Martine Barkats, Alexis Brice, Maria-Grazia Biferi, Sandro Alves, Thibaut Marais, Nathalie Cartier, Denis Furling
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, 2016, 11, pp.58. ⟨10.1186/s13024-016-0123-2⟩
Molecular Neurodegeneration, BioMed Central, 2016, 11, pp.58. ⟨10.1186/s13024-016-0123-2⟩
Molecular Neurodegeneration, 2016, 11, pp.58. ⟨10.1186/s13024-016-0123-2⟩
Molecular Neurodegeneration, BioMed Central, 2016, 11, pp.58. ⟨10.1186/s13024-016-0123-2⟩
Background We used lentiviral vectors (LVs) to generate a new SCA7 animal model overexpressing a truncated mutant ataxin-7 (MUT ATXN7) fragment in the mouse cerebellum, in order to characterize the specific neuropathological and behavioral consequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204f837e2215530a23517f3b46759167
https://hal.sorbonne-universite.fr/hal-01371536
https://hal.sorbonne-universite.fr/hal-01371536