Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Khalid A. Hajj"'
Autor:
Norbert Pardi, Daria Strelkova, Jason B. Miller, Mariah L. Arral, Khalid A. Hajj, Kathryn A. Whitehead, Namit Chaudhary, Daniel J. Siegwart, Drew Weissman, Mohamad-Gabriel Alameh, Jilian R. Melamed, Lukas Farbiak
Publikováno v:
J Control Release
Therapeutic mRNA has the potential to revolutionize the treatment of myriad diseases and, in 2020, facilitated the most rapid vaccine development in history. Among the substantial advances in mRNA technology made in recent years, the incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c434ce4b0aa634f63edc9228d663653
https://doi.org/10.1016/j.jconrel.2021.11.022
https://doi.org/10.1016/j.jconrel.2021.11.022
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
Autor:
Rebecca L. Ball, Jilian R. Melamed, Khalid A. Hajj, Kathryn A. Whitehead, Namit Chaudhary, Saigopalakrishna S. Yerneni, Nicholas G. Lamson
Publikováno v:
Nano Lett
The clinical translation of messengerRNA (mRNA) drugs has been slowed by a shortage of delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe the properties of a particularly potent branched-tail lipid nanopartic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde8978d38cf37c2e9276c563ab3ea4a
https://doi.org/10.1021/acs.nanolett.0c00596
https://doi.org/10.1021/acs.nanolett.0c00596
Publikováno v:
Experimental Biology and Medicine. 244:865-872
Mantle cell lymphoma is an aggressive subtype of non-Hodgkin’s lymphoma that claims the lives of tens of thousands of people every year. Although combination chemotherapy treatments such as CHOP have yielded promising outcomes in the clinic, the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c5f9806093440d415b16e2dda70ab9
https://doi.org/10.1177/1535370219857594
https://doi.org/10.1177/1535370219857594
Publikováno v:
Nano Letters. 18:3814-3822
Although mRNA and siRNA have significant therapeutic potential, their simultaneous delivery has not been previously explored. To facilitate the treatment of diseases associated with aberrant gene upregulation and downregulation, we sought to co-formu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231223c7a4928f034537822a2b853de6
https://doi.org/10.1021/acs.nanolett.8b01101
https://doi.org/10.1021/acs.nanolett.8b01101
Autor:
Sarah B. Deluty, Shridhar Singh, Daria Strelkova, Rebecca L. Ball, Khalid A. Hajj, Kathryn A. Whitehead, Christopher M. Knapp
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 15(6)
The potential of mRNA therapeutics will be realized only once safe and effective delivery systems are established. Unfortunately, delivery vehicle development is stymied by an inadequate understanding of how the molecular properties of a vehicle conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0d99515d0e56f84492a682d715cc3e
https://pubmed.ncbi.nlm.nih.gov/30637934
https://pubmed.ncbi.nlm.nih.gov/30637934
Autor:
Khalid A. Hajj, Kathryn A. Whitehead
Publikováno v:
Nature Reviews Materials. 2
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of dollars have been invested in the commercial development of mRNA drugs, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a77e22559feb0b910938149e976b07b
https://doi.org/10.1038/natrevmats.2017.56
https://doi.org/10.1038/natrevmats.2017.56