Výsledky vyhledávání - "Khaled. El-Adl"

Akademický článek

Biological activity and chemical characteristics studies of new oligomannose produced by Erwinia gerundensis

Autor: Shimaa K. Ali, F.M Mohamed, Ahmed H. El-Ghorab, Eman A. Hamed, Moustafa A. Aboel-Ainin, Mohamed A. Abdelgawad, Khaled El‐Adl, Hussein S. Mohamed

Publikováno v: Carbohydrate Polymer Technologies and Applications, Vol 8, Iss , Pp 100569- (2024)

Natural polymers have attracted considerable attention in recent decades among scientists due to their potential therapeutic uses, particularly as antimicrobial and antitumor agents. In this research, novel EPSs were extracted from garlic rhizosphere

Externí odkaz: https://doaj.org/article/e9391de5a25b48d78e8fb04ef0f4cba4

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Akademický článek

Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities

Autor: Amany H. El-Zairy, Hussein S. Mohamed, Shimaa A. Ahmed, Sayed A. Ahmed, Mohammad K. Okla, Khaled El-Adl, Hamada AbdElgawad, Wael N. Hozzein

Publikováno v: Heliyon, Vol 10, Iss 21, Pp e39612- (2024)

Desert plants possess untapped potential for medicinal applications due to their rich phytochemical profiles. However, they need to be more explored. Thus, this study integrates advanced analytical, biochemical, and molecular techniques to investigat

Externí odkaz: https://doaj.org/article/813e6428af144c119c33f08c27913cb1

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Akademický článek

Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Autor: Alaa Elwan, Helmy Sakr, Abdel-Ghany A. El-Helby, Ahmed El-morsy, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Khaled El-Adl

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1556-1567 (2022)

Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c

Externí odkaz: https://doaj.org/article/1907c3888437467b9eb12bf092b11692

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Akademický článek

Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists

Autor: Mohamed A. Abdelgawad, Khaled El-Adl, Sanadelaslam S. A. El-Hddad, Mostafa M. Elhady, Nashwa M. Saleh, Mohamed M. Khalifa, Fathalla Khedr, Mohamed Alswah, AbdElAziz A. Nayl, Mohammed M. Ghoneim, Nour E. A. Abd El-Sattar

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 226 (2022)

Newly designed thiazolidine-2,4-diones 3–7a–c were synthesized, and their anticancer activities were screened against three cancer lines. They showed potent activities against HepG2 compared to the other HCT116 and MCF-7 tumor cell lines. Compoun

Externí odkaz: https://doaj.org/article/c18b326a90404f8caba435121323ff9b

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Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFRT790M tyrosine kinase inhibitors

Autor: Nada A. A. M. Aziz, Riham F. George, Khaled El-Adl, Walaa R. Mahmoud

Publikováno v: RSC Advances. 12:12913-12931

Fourteen recent thiazolidine-2,4-diones bearing furan and/or thiophene heterocyclic rings have been designed, synthesized and assessed for their anticancer activities against four human tumor cell lines HepG2, A549, MCF-7 and HCT-116 targeting both V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddb9896c6fc93c82536f0e7f53d56ace
https://doi.org/10.1039/d2ra01119k

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Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents

Autor: Mohamed Ayman El-Zahabi, Hazem Elkady, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Khaled. El-Adl

In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized compounds were evaluated for their cytotoxic activities against HepG-2, HCT-116, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db46a196ec3fac0d375af3a1051e6213

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