Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15R? complex and CD4+CD25+ T cells are the main targets

Autor: Fabrice Pierre, Jean Menanteau, Khaled Meflah, Euphémie Bassonga, Virginie Forest

Publikováno v: Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, Springer Verlag, 2005, 54 (1), pp.78-86. ⟨10.1007/s00262-004-0543-7⟩
Cancer Immunology, Immunotherapy, 2005, 54 (1), pp.78-86. ⟨10.1007/s00262-004-0543-7⟩

International audience; We have shown recently that some indigestible carbohydrate (short-chain fructo-oligosaccharides [sc-FOS]) reduced colon tumor incidence in Apc+/Min mice, and that this effect depended on a functional local immune system. In ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f12ca9a4ffa1b8ab32e3d2178ceb21b
https://doi.org/10.1007/s00262-004-0543-7

The p18 Truncated Form of Bax Behaves Like a Bcl-2 Homology Domain 3-only Protein

Autor: François M. Vallette, Lisa Oliver, Pierre-François Cartron, Philippe Juin, Khaled Meflah

Publikováno v: Journal of Biological Chemistry. 279:11503-11512

p21(Bax) is a pro-apoptotic member of the Bcl-2 family and is converted by calpain into a truncated form called p18(Bax). This proteolysis enhanced the apoptogenic properties of Bax by a mechanism not yet elucidated. We have shown recently that the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bd3d4f17f25d0a24b61bc1559ef7db
https://doi.org/10.1074/jbc.m311922200

Difference in antigenic determinant profiles between human and rat myeloperoxidase

Autor: Ronald J. Falk, Khaled Meflah, Y. Patry, Patrick H. Nachman, Vincent L.M. Esnault, M. A.P. Audrain

Publikováno v: Clinical and Experimental Immunology. 132:505-508

SUMMARY We tested whether rat and human MPO have similar antigenic determinants using 36 human MPO-ANCA positive sera, one mouse anti-rat MPO and four mouse anti-human MPO monoclonal reagents. Purified rat and human MPO were used in ELISA, with or wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b90b3e9a851aae887942d25fc5add98
https://doi.org/10.1046/j.1365-2249.2003.02175.x

The N-terminal End of Bax Contains a Mitochondrial-targeting Signal

Autor: Stéphen Manon, Khaled Meflah, François M. Vallette, Muriel Priault, Lisa Oliver, Pierre-François Cartron

Publikováno v: Journal of Biological Chemistry. 278:11633-11641

The translocation of Bax alpha, a pro-apoptotic member of the BCL-2 family from the cytosol to mitochondria, is a central event of the apoptotic program. We report here that the N-terminal (NT) end of Bax alpha, which contains its first alpha helix (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea7dc4e4e051dfbe25a94ecbde82076
https://doi.org/10.1074/jbc.m208955200

The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients

Autor: Lisa Oliver, Khaled Meflah, Pierre-François Cartron, Pascal Jézéquel, Stéphane Martin, Carole Moreau, Marie-Thérèse LeCabellec, François M. Vallette

Publikováno v: Human Molecular Genetics. 11:675-687

Pro- and anti-apoptotic members of the BCL-2 family play a central role in the implementation of apoptosis. Bax, a pro-apoptotic member of this family, has as such been considered as a potential tumor suppressor. Here, we have examined the expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf4835973dd048998fd02c548846e0c
https://doi.org/10.1093/hmg/11.6.675