Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Khaled Essawi"'
Autor:
Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au
Externí odkaz:
https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
Waleed Hakami, Gasim Dobie, Abdullah A Mobarki, Aymen M Madkhali, Mohmmad S. Akhter, Abdulrahim R Hakami, Mohammed H Nahari, Yahya H Matari, Khaled Essawi, Ali Hakamy, Mohammad Algahtani, Denise E Jackson, Hassan A Hamali
Publikováno v:
European Journal of Inflammation, Vol 21 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a global concern with high morbidity and mortality rates. The role of endothelial cells in the progress of COVID-19 is well established. Therefore, the current study aimed to measu
Externí odkaz:
https://doaj.org/article/cee8897484b94aefb66f9f0b116fa9e5
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 276-285 (2021)
Genome editing is potentially a curative technique available to all individuals with β-hemoglobinopathies, including sickle cell disease (SCD). Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that nat
Externí odkaz:
https://doaj.org/article/0228fe37fd1a4d9d890c97a21cc6c425
Autor:
Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale, Naoya Uchida
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/07b8e6884a6c45098aefde61ecdd133f
Akademický článek
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Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 276-285 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Genome editing is potentially a curative technique available to all individuals with β-hemoglobinopathies, including sickle cell disease (SCD). Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30786ea1eed24ec3de953887c2bfacd
https://doi.org/10.1016/j.omtm.2021.09.010
https://doi.org/10.1016/j.omtm.2021.09.010
Autor:
Selami Demirci, Khaled Essawi, Paula Germino-Watnick, Xiong Liu, Waleed Hakami, John F. Tisdale
Publikováno v:
CRISPR J
With the advent of new genome editing technologies and the emphasis placed on their optimization, the genetic and phenotypic correction of a plethora of diseases sit on the horizon. Ideally, genome editing approaches would provide long-term solutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aedec007d8e7b2fb7a09541fad4ffb6
https://pubmed.ncbi.nlm.nih.gov/36260301
https://pubmed.ncbi.nlm.nih.gov/36260301
Autor:
Alexis Leonard, Nicholas P. Restifo, Juan J. Haro-Mora, Naritaka Tamaoki, Khaled Essawi, Naoya Uchida, Selami Demirci, Claire M. Drysdale, Keyvan Keyvanfar, Raul Vizcardo, Daniela Malide, John F. Tisdale
Publikováno v:
Stem Cell Research & Therapy
Background Ex vivo production of hematopoietic stem/precursor cells (HSPCs) represents a promising versatile approach for blood disorders. Methods To derive definitive HSPCs from human embryonic stem cells (ESCs), we differentiated mesodermally speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a0264199702beeec39dd37b2d6c76d
https://pubmed.ncbi.nlm.nih.gov/33334372
https://pubmed.ncbi.nlm.nih.gov/33334372
Autor:
Myriam Armant, Selami Demirci, David R. Williams, Amornrat Tangprasittipap, Stacy Maitland, Pengpeng Liu, Daniel E. Bauer, J. Keith Joung, Karl Petri, Danilo Pellin, Jing Zeng, John F. Tisdale, Linda Yingqi Lin, John P. Manis, Kevin Luk, Daniela Abriss, Scot A. Wolfe, Yuxuan Wu, Christian Brendel, Shengdar Q. Tsai, Luca Pinello, Varun Katta, Jonathan Y. Hsu, Chokdee Vong, Robert E. Donahue, Shondra M. Pruett-Miller, My Anh Nguyen, Khaled Essawi, Naoya Uchida, Duantida Songdej, Shaina N. Porter, Vikram Pattanayak, Suradej Hongeng, Marioara-Felicia Ciuculescu, Esther Mintzer
Publikováno v:
Blood. 138:1852-1852
Targeting the BCL11A erythroid enhancer by gene editing is a promising approach to fetal hemoglobin induction for beta-hemoglobinopathies. HbF levels vary widely among individuals, suggesting potential heterogeneity in HbF responses after therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b31d6663fd5394fffb41a755f4c19c5
https://doi.org/10.1182/blood-2021-152634
https://doi.org/10.1182/blood-2021-152634