Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation

Autor: Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)

CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au

Externí odkaz: https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec

Correlation of circulating endothelial markers in COVID-19 patients admitted to the intensive care unit with laboratory data

Autor: Waleed Hakami, Gasim Dobie, Abdullah A Mobarki, Aymen M Madkhali, Mohmmad S. Akhter, Abdulrahim R Hakami, Mohammed H Nahari, Yahya H Matari, Khaled Essawi, Ali Hakamy, Mohammad Algahtani, Denise E Jackson, Hassan A Hamali

Publikováno v: European Journal of Inflammation, Vol 21 (2023)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a global concern with high morbidity and mortality rates. The role of endothelial cells in the progress of COVID-19 is well established. Therefore, the current study aimed to measu

Externí odkaz: https://doaj.org/article/cee8897484b94aefb66f9f0b116fa9e5

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CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease

Autor: Alexis Leonard, Khaled Essawi, Selami Demirci, John F. Tisdale

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 276-285 (2021)
Molecular Therapy. Methods & Clinical Development

Genome editing is potentially a curative technique available to all individuals with β-hemoglobinopathies, including sickle cell disease (SCD). Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30786ea1eed24ec3de953887c2bfacd
https://doi.org/10.1016/j.omtm.2021.09.010

Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19).

Autor: Gasim Dobie -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Hassan A Hamali -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Abdullah A Mobarki -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Muhammad Saboor -; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, UAE., Mohammad S Akhter -; Department of Medical Laboratory Technology, Jazan University, Gizan, Saudi Arabia., Khaled Essawi Abdulrahim R Hakami -; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha Saudi Arabia., Mohammed H Nahari -; Department of Medical Laboratory Technology, Najran University, Najran, Saudi Arabia., Mohamed A Kolaiby -; Department of Hematology and Blood Bank, Sabya General Hospital, Gizan, Saudi Arabia., Yahya H Matari -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Essa Atafi -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Ghalib Ghubiri -; Department of Hematology and Blood Bank, Baish General Hospital, Gizan, Saudi Arabia., Abdulrahman A Alhamzi -; Department of Hematology and Blood Bank, King Fahd Central Hospital, Gizan, Saudi Arabia., Abdulrhman Alhamzi -; Department of Planning and Development, King Fahd Central Hospital, Gizan, Saudi Arabia., Amr J Halawani -; Deaprtment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Abdullah Hamadi -; Department of Medical Laboratory Technology, Tabuk University, Tabuk, Saudi Arabia., Denise E Jackson -; Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC, Austra.

Publikováno v: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2023 Jul; Vol. 36 (4), pp. 1211-1215.