Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Khaled A. M. Abouzid"'
Autor:
Khulood H. Oudah, Mazin A. A. Najm, Reham F. Barghash, Omnia Kutkat, Mohamed GabAllah, Amgad Albohy, Khaled A. M. Abouzid
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract The search for new molecules targeting SARS-CoV-2 has been a priority since 2020. The continuous evolution of new mutants increases the need for more research in the area. One way to find new leads is to repurpose existing drugs and molecule
Externí odkaz:
https://doaj.org/article/1103d9c12dac43f5868d490f99f303ba
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-18 (2023)
Abstract New thienopyrimidine derivatives were designed and synthesized as GSK-3β inhibitors based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b and 6a were found to be moderate GSK-3β inhibitors with IC50s
Externí odkaz:
https://doaj.org/article/cbc2cb83300d45038d4d9da4cf299556
Autor:
Abeer H. A. Abdelhafiz, Rabah A. T. Serya, Deena S. Lasheen, Nessa Wang, Mansour Sobeh, Michael Wink, Khaled A. M. Abouzid
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2710-2724 (2022)
Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain
Externí odkaz:
https://doaj.org/article/57eeea20c5b242c7b876f7be7406cf6f
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 315-332 (2022)
Cancer is one of the most aggressive diseases characterised by abnormal growth and uncontrolled cell division. PI3K is a lipid kinase involved in cancer progression which makes it fruitful target for cancer control. 28 new morpholine based thieno[2,3
Externí odkaz:
https://doaj.org/article/9a8d84d5b8a74cfb849e85697867fe18
Autor:
Mohamed S. Refaey, Marwa A. A. Fayed, Omnia Kutkat, Yassmin Moatasim, Nahla Sameh Tolba, Anis Anis, Ahmed M. Elshorbagy, Khloud Nassar, Khaled A. M. Abouzid, Yaseen A. M. M. Elshaier, Mohamed F. El-Badawy
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 7, Pp 104813- (2023)
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has opened the door to potential threats of the respiratory system. The discovery of drugs from natural sources is one of the most important strategies for tre
Externí odkaz:
https://doaj.org/article/84736723c20749ae8e8932d91a9fcaaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1290-1311 (2021)
A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c
Externí odkaz:
https://doaj.org/article/eeb7eae82d0b459aa242f5b53f80ad11
Publikováno v:
ACS Omega, Vol 5, Iss 32, Pp 20170-20186 (2020)
Externí odkaz:
https://doaj.org/article/d3f55824c3944f2981e05173d4f95e33
Autor:
Marwa Sharaky, Marwa Kamel, Marwa A. Aziz, Mervat Omran, Monira M. Rageh, Khaled A. M. Abouzid, Samia A. Shouman
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1641-1656 (2020)
Breast cancer (BC) and endocrine resistance to chemotherapy are challenging problems where angiogenesis plays fundamental roles. Thus, targeting of VEGFR-2 signalling pathway has been an attractive approach. In this study, we synthesised a new sorafe
Externí odkaz:
https://doaj.org/article/56d9fddca9684cd4b4cc0bc6d62994bf
Publikováno v:
Archives of Pharmaceutical Sciences Ain Shams University, Vol 3, Iss 2, Pp 228-245 (2019)
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reac
Externí odkaz:
https://doaj.org/article/65b9e74ee2a2427a814e1888065b7dcb
Autor:
Tamer Nasr, Ahmed M. Aboshanab, George Mpekoulis, Antonios Drakopoulos, Niki Vassilaki, Grigoris Zoidis, Khaled A. M. Abouzid, Wafaa Zaghary
Publikováno v:
Viruses, Vol 14, Iss 12, p 2767 (2022)
Chronic hepatitis C virus (HCV) infections are a worldwide medical problem responsible for diverse types of liver diseases. The NS5B polymerase enzyme has become a very interesting target for the development of anti-HCV drugs owing to its fundamental
Externí odkaz:
https://doaj.org/article/21347f9737494097a34e238a7ef24399