Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Khalad, Karram"'
Autor:
Monika Bednarczyk, Vanessa Bolduan, Maximilian Haist, Henner Stege, Christoph Hieber, Lisa Johann, Carsten Schelmbauer, Michaela Blanfeld, Khalad Karram, Jenny Schunke, Tanja Klaus, Ingrid Tubbe, Evelyn Montermann, Nadine Röhrig, Maike Hartmann, Jana Schlosser, Tobias Bopp, Björn E Clausen, Ari Waisman, Matthias Bros, Stephan Grabbe
Publikováno v:
Cells, Vol 11, Iss 14, p 2188 (2022)
Heterodimeric β2 integrin surface receptors (CD11a-d/CD18) are specifically expressed by leukocytes that contribute to pathogen uptake, cell migration, immunological synapse formation and cell signaling. In humans, the loss of CD18 expression result
Externí odkaz:
https://doaj.org/article/dd3cdfc4fb2c4aa4ba1f88b6cdbadb3b
Autor:
Alma Nazlie Mohebiany, Nishada Shakunty Ramphal, Khalad Karram, Giovanni Di Liberto, Tanja Novkovic, Matthias Klein, Federico Marini, Mario Kreutzfeldt, Franziska Härtner, Sonja Maria Lacher, Tobias Bopp, Thomas Mittmann, Doron Merkler, Ari Waisman
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1585-1597.e6 (2020)
Summary: Tumor-necrosis-factor-alpha-induced protein 3 (TNFAIP3), or A20, is a ubiquitin-modifying protein and negative regulator of canonical nuclear factor κB (NF-κB) signaling. Several single-nucleotide polymorphisms in TNFAIP3 are associated wi
Externí odkaz:
https://doaj.org/article/0aeba8e512d14e6a9d9248907b177a1e
Autor:
Florian Wanke, Sonja Moos, Andrew L. Croxford, André P. Heinen, Stephanie Gräf, Bettina Kalt, Denise Tischner, Juan Zhang, Isabelle Christen, Julia Bruttger, Nir Yogev, Yilang Tang, Morad Zayoud, Nicole Israel, Khalad Karram, Sonja Reißig, Sonja M. Lacher, Christian Reichhold, Ilgiz A. Mufazalov, Avraham Ben-Nun, Tanja Kuhlmann, Nina Wettschureck, Andreas W. Sailer, Klaus Rajewsky, Stefano Casola, Ari Waisman, Florian C. Kurschus
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1270-1284 (2017)
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell locali
Externí odkaz:
https://doaj.org/article/4430b96b5b16407db24119db388b3fa8
Background Isolation of neurons from the adult mouse CNS is important in order to study their gene expression during development or the course of different diseases. New methods Here we present two different methods for the enrichment or isolation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758d54fb5b09d0bcddad86dfaf1e28d
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196726 (2018)
The neurofibromatosis type 2 (NF2) tumor suppressor protein Merlin functions as a negative regulator of cell growth and actin dynamics in different cell types amongst which Schwann cells have been extensively studied. In contrast, the presence and th
Externí odkaz:
https://doaj.org/article/6fa836348ac3498fb5902a41b9d62aab
Autor:
Florian C. Kurschus, Tobias Bopp, Ingo Bechman, Ari Waisman, Harald Binder, Silvia Cardoso, Subhashini Bolisetty, Lisa Johann, Judith Hauptmann, Federico Marini, Elisa Colombo, Ilgiz A. Mufazalov, Markus Schwaninger, Miguel P. Soares, Judith Strauß, Sonja Moos, Anupam Agarwal, Fred Lühder, Matthias Klein, Maja Kitic, Florian Wanke, Khalad Karram, Martin Krueger, Tommy Regen
Publikováno v:
Acta Neuropathologica
The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c1d5372da9596b322b605790b0b4bf
https://doi.org/10.1007/s00401-020-02187-x
https://doi.org/10.1007/s00401-020-02187-x
Autor:
Frank Maus, Dominik Sakry, Fabien Binamé, Khalad Karram, Krishnaraj Rajalingam, Colin Watts, Richard Heywood, Rejko Krüger, Judith Stegmüller, Hauke B Werner, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Jacqueline Trotter
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137311 (2015)
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress r
Externí odkaz:
https://doaj.org/article/4bd26238ae5b4408949dac8491530e13
Autor:
Christian Haberlandt, Amin Derouiche, Alexandra Wyczynski, Julia Haseleu, Jörg Pohle, Khalad Karram, Jacqueline Trotter, Gerald Seifert, Michael Frotscher, Christian Steinhäuser, Ronald Jabs
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17575 (2011)
NG2 cells, the fourth type of glia in the mammalian CNS, receive synaptic input from neurons. The function of this innervation is unknown yet. Postsynaptic changes in intracellular Ca(2+)-concentration ([Ca(2+)](i)) might be a possible consequence. W
Externí odkaz:
https://doaj.org/article/7a8d5e365f1040e99ec7014b2c16a23d
Autor:
Patrizia Stoitzner, Nathalie Diener, Aimin Jiang, Ronald A. Backer, Khalad Karram, Sonja Zahner, Björn E. Clausen, Christoph H. Tripp, Anna Brand, Ira Mellman
Publikováno v:
The Journal of investigative dermatology. 140(1)
The cell adhesion molecule E-cadherin is a major component of adherens junctions and marks Langerhans cells (LC), the only dendritic cell (DC) population of the epidermis. LC form a dense network and attach themselves to the surrounding keratinocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb20144b4ca046b82522ffbc57fb6cd
https://pubmed.ncbi.nlm.nih.gov/31260672
https://pubmed.ncbi.nlm.nih.gov/31260672
Autor:
Klaus Rajewsky, Nina Wettschureck, Stephanie Gräf, Ilgiz A. Mufazalov, Morad Zayoud, Tanja Kuhlmann, Sonja Moos, Denise Tischner, Yilang Tang, Florian C. Kurschus, Andreas W. Sailer, Nir Yogev, Andrew L. Croxford, Avraham Ben-Nun, Julia Bruttger, Bettina Kalt, Sonja M. Lacher, Ari Waisman, Isabelle Christen, Sonja Reißig, André P. Heinen, Khalad Karram, Christian Reichhold, Florian Wanke, Stefano Casola, Nicole Israel, Juan Zhang
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1270-1284 (2017)
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7{alpha},25-OHC, direct immune cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7264f423d59d19da8ed1a904ee31b98f