Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Khakim G. Muradov"'
Publikováno v:
Biochemistry. 42:3305-3310
Photoreceptor cGMP phosphodiesterase (PDE6) is the effector enzyme in the vertebrate visual transduction cascade. The activity of rod PDE6 catalytic alpha- and beta-subunits is blocked in the dark by two inhibitory Pgamma-subunits. The inhibition is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274278a33bf73f6b956e8f6c24c008bf
https://doi.org/10.1021/bi027095x
https://doi.org/10.1021/bi027095x
Autor:
Khakim G. Muradov, Nikolai O. Artemyev
Publikováno v:
Biochemistry. 39:3937-3942
The N-terminal regions of the heterotrimeric G-protein alpha-subunits represent one of the major Gbetagamma contact sites and have been implicated in an interaction with G-protein-coupled receptors. To probe the role of the N-terminal domain of trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b052ba5c2971836f1094b0827b8228f8
https://doi.org/10.1021/bi992156l
https://doi.org/10.1021/bi992156l
Autor:
Nikolai O. Artemyev, Khakim G. Muradov
Publikováno v:
Journal of Biological Chemistry. 275:6969-6974
A missense mutation, G38D, was found in the rod transducin alpha subunit (Galpha(t)) in individuals with the Nougaret form of dominant stationary night blindness. To elucidate the mechanism of Nougaret night blindness, we have examined the key functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908de2cbbcddf358e95d488120f27713
https://doi.org/10.1074/jbc.275.10.6969
https://doi.org/10.1074/jbc.275.10.6969
Publikováno v:
Journal of Biological Chemistry. 275:2669-2675
The C-terminal regions of the heterotrimeric G protein alpha-subunits play key roles in selective activation of G proteins by their cognate receptors. In this study, mutant G(s)alpha proteins with substitutions by C-terminal residues of transducin (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9494219a2683e6d7fbd724e6bf545a5d
https://doi.org/10.1074/jbc.275.4.2669
https://doi.org/10.1074/jbc.275.4.2669
Publikováno v:
Journal of Biological Chemistry. 274:7865-7869
The visual GTP-binding protein, transducin, couples light-activated rhodopsin (R*) with the effector enzyme, cGMP phosphodiesterase in vertebrate photoreceptor cells. The region corresponding to the alpha4-helix and alpha4-beta6 loop of the transduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d092a0dde9c584a668ef091384399db
https://doi.org/10.1074/jbc.274.12.7865
https://doi.org/10.1074/jbc.274.12.7865
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 307
An absolute majority of cyclic nucleotide phosphodiesterases (PDEs) form catalytic dimers. The structural determinants and functional significance of PDE dimerization are poorly understood. Furthermore, all known dimeric PDEs with the exception of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b00310fa560e7569561eab1f8a691f0
https://pubmed.ncbi.nlm.nih.gov/15988069
https://pubmed.ncbi.nlm.nih.gov/15988069
An absolute majority of cyclic nucleotide phosphodiesterases (PDEs) form catalytic dimers. The structural determinants and functional significance of PDE dimerization are poorly understood. Furthermore, all known dimeric PDEs with the exception of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8df8356ad6e3112bda46b596dd4b545
https://doi.org/10.1385/1-59259-839-0:263
https://doi.org/10.1385/1-59259-839-0:263
Autor:
Kimberly K. Boyd, Sergio E. Martinez, Joseph A. Beavo, Nikolai O. Artemyev, Khakim G. Muradov
Retinal rod cGMP phosphodiesterase (PDE6 family) is the effector enzyme in the vertebrate visual transduction cascade. Unlike other known PDEs that form catalytic homodimers, the rod PDE6 catalytic core is a heterodimer composed of alpha and beta sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eaae51b741e622c8d4af335734dd14d
http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12531898
http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12531898
Publikováno v:
Biochemistry. 41(12)
Retinal rod and cone cGMP phosphodiesterases (PDE6 family) function as the effector enzyme in the vertebrate visual transduction cascade. The activity of PDE6 catalytic subunits is controlled by the Pgamma-subunits. In addition to the inhibition of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6854ed68747cdae090a0d464d5c5cf
https://pubmed.ncbi.nlm.nih.gov/11900530
https://pubmed.ncbi.nlm.nih.gov/11900530