Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Khaja Azhar Hussain"'
Autor:
Khaja Azhar Hussain, Yasuhiro Suzuki, Hiroyuki Gatanaga, Damaris D. Yeh, Hiroaki Mitsuya, Arun K. Ghosh, Debananda Das
Publikováno v:
Journal of Biological Chemistry. 281:1241-1250
HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness. Among the amino acid substitutions identified in Gag noncleavage sites in HIV-1 variants resistant to protease inhibitors, H219Q (Gatanaga, H., Suzuki, Y., Tsang,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59eccde9461bf2de08f5ecf034da127
https://doi.org/10.1074/jbc.m505920200
https://doi.org/10.1074/jbc.m505920200
Publikováno v:
Antiviral Research. 54:29-36
The human immunodeficiency virus type 1 (HIV-1) protease inhibitor UIC-PI (1) was developed via structure-based design and incorporated a novel bis-tetrahydrofuran (bis-THF) ligand in the (R)-(hydroxyethyl)sulfonamide based isostere. The EC(50) and E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50968ea134bee2a141a487195cbb9b8
https://doi.org/10.1016/s0166-3542(01)00209-1
https://doi.org/10.1016/s0166-3542(01)00209-1
Autor:
Jordan Tang, Dongwoo Shin, Geoffrey Bilcer, Cynthia J. Harwood, Jeffrey A. Loy, Lin Hong, Reiko Kawahama, Chan Nguyen, Arun K. Ghosh, Jacques Ermolieff, Gerald Koelsch, Khaja Azhar Hussain
Publikováno v:
Journal of Medicinal Chemistry. 44:2865-2868
Memapsin 2 (beta-secretase) is one of two proteases that cleave the beta-amyloid precursor protein (APP) to produce the 40-42 residue amyloid-beta peptide (Abeta) in the human brain, a key event in the progression of Alzheimer's disease. On the basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a24e032164ae62b0bb944452d3b7e1
https://doi.org/10.1021/jm0101803
https://doi.org/10.1021/jm0101803
Autor:
Dongwoo Shin, Arun K. Ghosh, Louis E. Holland, K. Krishnan, Jim Buthod, Lisa M. Swanson, D. Eric Walters, Hanna Cho, Khaja Azhar Hussain
Publikováno v:
Il Farmaco. 56:29-32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81349af37353d07560525b463f6dc74a
https://doi.org/10.1016/s0014-827x(01)01025-4
https://doi.org/10.1016/s0014-827x(01)01025-4
Autor:
John F. Kincaid, Jim Buthod, Wonhwa Cho, Clare Rudall, Arun K. Ghosh, Hanna Cho, Louis E. Holland, Yumee Koo, D. Eric Walters, Khaja Azhar Hussain, K. Krishnan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:687-690
Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b0021c70f05cdc219d496a275f6a02
https://doi.org/10.1016/s0960-894x(98)00098-5
https://doi.org/10.1016/s0960-894x(98)00098-5
Publikováno v:
Tetrahedron Letters. 38:7171-7174
Aldol reactions of bidentate aldehydes and cis-1-arylsulfonamido-2-indanyl ester derived titanium enolates proceed with excellent syn-diastereoselectivities and good to excellent isolated yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcf76e7a21c2450e1b311ae21c73546
https://doi.org/10.1016/s0040-4039(97)01765-6
https://doi.org/10.1016/s0040-4039(97)01765-6
Publikováno v:
ChemInform. 29
Aldol reactions of bidentate aldehydes and cis-1-arylsulfonamido-2-indanyl ester derived titanium enolates proceed with excellent syn-diastereoselectivities and good to excellent isolated yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96fb5b9e3d32a12ff7fab4b972c6fa6
https://doi.org/10.1002/chin.199801075
https://doi.org/10.1002/chin.199801075
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1942a28dda78977e3fece9b1c915a87
https://doi.org/10.1002/chin.199803156
https://doi.org/10.1002/chin.199803156
Autor:
Arun K. Ghosh, Khaja Azhar Hussain
Publikováno v:
ChemInform. 29
Alkoxycarbonylation of amines followed by ring-closing metathesis of the resulting dienes with Grubbs catalyst (25-50 mol%) provided convenient access to 14-16 membered macrocyclic urethanes in very good yields. 0 1998 Elsevier Science Ltd. All right
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe353d95c89427824c172af151bf1c07
https://doi.org/10.1002/chin.199830196
https://doi.org/10.1002/chin.199830196
Autor:
Dongwoo Shin, K. Krishnan, Hanna Cho, Louis E. Holland, Lisa M. Swanson, Khaja Azhar Hussain, Jim Buthod, Arun K. Ghosh, D. Eric Walters
Publikováno v:
ChemInform. 32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2c2b5688d6d2a818d8a1ae144af1bff
https://doi.org/10.1002/chin.200128284
https://doi.org/10.1002/chin.200128284