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Archiv der Pharmazie. 350(11)
Thienopyrimidines (TP), comprising a thiophene ring fused with pyrimidine, are famous bioisosteres to purines, an essential part of the human metabolome. This scaffold has become an interesting structural element in the development of pharmaceutical
Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt Manuscript received 23 September 1986, accepted 2 August 1986 The reaction of 2-amino-4-cbloro-, 4-amino-2-chloro- and 2,4-dichloro-6-methylpyrimidines with primary a
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