Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Khadiza Zaman"'
Autor:
Ammar Kapic, Khadiza Zaman, Vien Nguyen, George C. Neagu, Nathalie Sumien, Laszlo Prokai, Katalin Prokai-Tatrai
Publikováno v:
Cells, Vol 13, Iss 13, p 1126 (2024)
We report a three-pronged phenotypic evaluation of the bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) that selectively produces 17β-estradiol (E2) in the retina after topical administration and halts glaucomatous neurodegenerati
Externí odkaz:
https://doaj.org/article/a96fc23a8b1348c79b345433a2125916
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12592 (2023)
Elevated intraocular pressure is considered a major cause of glaucomatous retinal neurodegeneration. To facilitate a better understanding of the underlying molecular processes and mechanisms, we report a study focusing on alterations of the retina pr
Externí odkaz:
https://doaj.org/article/7b766d53ac494552b1ad5aa501e72ba0
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1392 (2021)
We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome profile in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by our treatment. These proteins were assemble
Externí odkaz:
https://doaj.org/article/ed068232e1d4455496dca9400539a19d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1686 (2021)
The widely used rat uterotrophic assay to assess known and potential estrogenic compounds only considers uterine weight gain as endpoint measurement. To complement this method with an advanced technology that reveals molecular targets, we analyzed ch
Externí odkaz:
https://doaj.org/article/692a15b321f34f65bcf82edd9bf6db63
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 167 (2020)
The early signaling events involved in oxidant recognition and triggering of oxidant-specific defense mechanisms to counteract oxidative stress still remain largely elusive. Our discovery driven comparative proteomics analysis revealed unique early s
Externí odkaz:
https://doaj.org/article/cee87251dddc49b8abda24c457eb7588
Autor:
Katalin Prokai-Tatrai, Vien Nguyen, Daniel L. De La Cruz, Rebecca Guerra, Khadiza Zaman, Fatima Rahlouni, Laszlo Prokai
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 456 (2020)
The purpose of this study was to explore retina-targeted delivery of 17β-estradiol (E2), a powerful neuroprotectant, by its bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) administered as eye drops in animal models. Compared to t
Externí odkaz:
https://doaj.org/article/556f017cb302405a9b0388009608c4da
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 101 (2020)
To facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms, this proteomics study focused on analyzing target engagements through the identification of functional protein networks impact
Externí odkaz:
https://doaj.org/article/8dc9d8cbc99842ba867a59b298eb5314
Publikováno v:
Mass Spectrometry Reviews. 42:1032-1062
A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry'
Autor:
János Garai, Balázs Radnai, Eszter Vámos, Dominika Kovács, Viola Bagóné Vántus, Zoltán Rumbus, Eszter Pákai, András Garami, Gergely Gulyás-Fekete, Attila Agócs, Marcell Krekó, Khadiza Zaman, László Prókai, László Őrfi, Péter B. Jakus, Tamás Lóránd
Publikováno v:
European Journal of Medicinal Chemistry. 247:115050
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with enzymatic activities. Anti-inflammatory effects of MIF enzyme inhibitors indicate a link between its cytokine- and catalytic activities. Herein the synthesis, docking, an
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 167, p 167 (2021)
The early signaling events involved in oxidant recognition and triggering of oxidant-specific defense mechanisms to counteract oxidative stress still remain largely elusive. Our discovery driven comparative proteomics analysis revealed unique early s