Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis

Autor: Khadija M. Alawi, David Tandio, Jin Xu, Pratish Thakore, Georgia Papacleovoulou, Elizabeth S. Fernandes, Cristina Legido-Quigley, Catherine Williamson, Susan D. Brain

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Transient receptor potential canonical 5 (TRPC5), a calcium-permeable, non-selective cation channel is expressed in the periphery, but there is limited knowledge of its regulatory roles in vivo. Endogenous modulators of TRPC5 include a range

Externí odkaz: https://doaj.org/article/50ebdd5ef16b4a1fac47e63d32bcb9e7

Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis

Autor: Joao de Sousa Valente, Faseeha Ayaz, Patrik Keringer, Dibesh Thapa, Sabah Bharde, Xenia Kodji, Nurjahan Saleque, Fulye Argunhan, Khadija M. Alawi, Susan D. Brain

Publikováno v: Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100119-(2020)
Osteoarthritis and Cartilage Open

Introduction Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e39e542c4c6b8b0c548377632c98d00
http://www.sciencedirect.com/science/article/pii/S2665913120301199

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

Autor: Sara G. Romeo, Anjali P. Kusumbe, Khadija M Alawi, Saravana K. Ramasamy, Julia Rodrigues, Amit Singh

Publikováno v: Nature Cell Biology. 21(4)

Growth plate cartilage contributes to the generation of a large variety of shapes and sizes of skeletal elements in the mammalian system. The removal of cartilage and how this process regulates bone shape are not well understood. Here we identify a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d95abdb059fc0d5d7f0421a301ba792
http://ora.ox.ac.uk/objects/uuid:

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Autor: Claire A. Sand, Sarah Jane Smillie, Clive Gentry, Aisah A. Aubdool, Lihuan Liang, Susan D. Brain, Elizabeth S. Fernandes, Julie Keeble, Stuart Bevan, Marzia Malcangio, Robin Salamon, Matthew Arno, F. A. Russell, Khadija M. Alawi, Jennifer V. Bodkin

Publikováno v: Fernandes, E S, Russell, F A, Alawi, K M, Sand, C, Liang, L, Salamon, R, Bodkin, J V, Aubdool, A A, Arno, M, Gentry, C, Smillie, S J, Bevan, S, Keeble, J E, Malcangio, M & Brain, S D 2016, ' Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner ', Arthritis Research and Therapy, vol. 18, no. 1, 7 . https://doi.org/10.1186/s13075-015-0905-x
Arthritis Research & Therapy

Background: The effect of cold temperature on arthritis symptoms is unclear. The aim of this study was to investigate how environmental cold affects pain and blood flow in mono-arthritic mice, and examine a role for transient receptor potential ankyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c87887d501eca79b67f879334f8922
https://doi.org/10.1186/s13075-015-0905-x

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

Autor: Khadija M. Alawi, Julie Keeble

Publikováno v: Pharmacology & Therapeutics. 125:181-195

The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers. In addition, endogenous compounds, in particular the endogenous cannabino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23aa26a9df596a55f952fb7242e982d
https://doi.org/10.1016/j.pharmthera.2009.10.005