Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Khader Ghneim"'
Autor:
Brian Ferrari, Amanda Cabral Da Silva, Ken H. Liu, Evgeniya V. Saidakova, Larisa B. Korolevskaya, Konstantin V. Shmagel, Carey Shive, Gabriela Pacheco Sanchez, Mauricio Retuerto, Ashish Arunkumar Sharma, Khader Ghneim, Laura Noel-Romas, Benigno Rodriguez, Mahmoud A. Ghannoum, Peter P. Hunt, Steven G. Deeks, Adam D. Burgener, Dean P. Jones, Mirela A. Dobre, Vincent C. Marconi, Rafick-Pierre Sekaly, Souheil-Antoine Younes
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their CD4+ T cell count after antiretroviral therapy (ART). INRs have low CD4+ T cell coun
Externí odkaz:
https://doaj.org/article/2e7dbc6137fc40d5aa924fb147bf5c0a
Autor:
Louise A. Swainson, Ashish Arunkumar Sharma, Khader Ghneim, Susan Pereira Ribeiro, Peter Wilkinson, Richard M. Dunham, Rebecca G. Albright, Samson Wong, Jacob D. Estes, Michael Piatak, Steven G. Deeks, Peter W. Hunt, Rafick-Pierre Sekaly, Joseph M. McCune
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Type I IFNs (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic TI-IFN signaling in the context of HIV infection treated with antiretroviral therapy (ART) also
Externí odkaz:
https://doaj.org/article/217cc5fdb60549db8545e6d82593b897
Autor:
Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L Harper, Colin T King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A Delman, Theron Stuart, Michael Lowe, Jason M Brenchley, Cynthia A Derdeyn, Kirk Easley, Rafick P Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C Marconi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://doaj.org/article/067e37f438b34fd7827433be61b176ba
Autor:
Julian H Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J Cameron, Miranda Z Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H Prince, Jennifer F Hoy, Nicolas Chomont, Rémi Fromentin, Francesco A Procopio, Joumana Zeidan, Sarah Palmer, Lina Odevall, Ricky W Johnstone, Ben P Martin, Elizabeth Sinclair, Steven G Deeks, Daria J Hazuda, Paul U Cameron, Rafick-Pierre Sékaly, Sharon R Lewin
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004473 (2014)
UnlabelledHuman immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibit
Externí odkaz:
https://doaj.org/article/b6cb4c8618164166ada773318ee06d1f
Autor:
Marie-Line Goulet, David Olagnier, Zhengyun Xu, Suzanne Paz, S. Mehdi Belgnaoui, Erin I. Lafferty, Valérie Janelle, Meztli Arguello, Marilene Paquet, Zhong He, Khader Ghneim, Stephanie Richards, Andrew Smith, Peter Wilkinson, Mark Cameron, Ulrich Kalinke, Salman Qureshi, Alain Lamarre, Elias K. Haddad, Rafick Pierre Sekaly, Suraj Peri, Siddharth Balachandran, Rongtuan Lin, John Hiscott
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/31ff885c3dec4a63a7ebe3044365e2dc
Autor:
Marie-Line Goulet, David Olagnier, Zhengyun Xu, Suzanne Paz, S Mehdi Belgnaoui, Erin I Lafferty, Valérie Janelle, Meztli Arguello, Marilene Paquet, Khader Ghneim, Stephanie Richards, Andrew Smith, Peter Wilkinson, Mark Cameron, Ulrich Kalinke, Salman Qureshi, Alain Lamarre, Elias K Haddad, Rafick Pierre Sekaly, Suraj Peri, Siddharth Balachandran, Rongtuan Lin, John Hiscott
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003298 (2013)
The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5' triphosphate (5'ppp) terminal structure. In the present study, an RNA ago
Externí odkaz:
https://doaj.org/article/20a18ff8776945988e4476c5838ae3a4
Autor:
Carmen Elena Gómez, Beatriz Perdiguero, Victoria Jiménez, Abdelali Filali-Mouhim, Khader Ghneim, Elias K Haddad, Esther D Quakkelaar, Julie Delaloye, Alexandre Harari, Thierry Roger, Thomas Duhen, Rafick P Sékaly, Cornelis J M Melief, Thierry Calandra, Federica Sallusto, Antonio Lanzavecchia, Ralf Wagner, Giuseppe Pantaleo, Mariano Esteban
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35485 (2012)
Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we descr
Externí odkaz:
https://doaj.org/article/d2fbd70e5f1c483eba57e0bcefc85a23
Autor:
Carmen Elena Gómez, Beatriz Perdiguero, Victoria Jiménez, Abdelali Filali-Mouhim, Khader Ghneim, Elias K. Haddad, Esther D. Quakkerlaar, Julie Delaloye, Alexandre Harari, Thierry Roger, Thomas Duhen, Rafick P. Sékaly, Cornelis J. M. Melief, Thierry Calandra, Federica Sallusto, Antonio Lanzavecchia, Ralf Wagner, Giuseppe Pantaleo, Mariano Esteban
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/3639a6b4e6374fd2b74863fdbcdc4134
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication
Autor:
Merlin L. Robb, Xian Chen, Carolina Garrido, Elizabeth Holley-Guthrie, Lishan Su, Liang Cheng, Haitao Guo, Jenny P.-Y. Ting, Khader Ghneim, David M. Margolis, Leigh Anne Eller, Li Wang, Qi Wang, Elena Rampanelli, Rafick-Pierre Sekaly
Publikováno v:
Nature immunology
Nature immunology, 22(4), 423-433. Nature Publishing Group
Nature immunology, 22(4), 423-433. Nature Publishing Group
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4+ T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4+ T cells from patients with HIV-1 and reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827c5bbae1632cfe1cb28686f79582d6
https://doi.org/10.1038/s41590-021-00898-1
https://doi.org/10.1038/s41590-021-00898-1
Autor:
Khader Ghneim, Ashish Arunkumar Sharma, Susan Pereira Ribeiro, Slim Fourati, Jeffery Ahlers, Ali Filali-Mouhim, Deanna Kulpa, Xuan Xu, Jessica Brehm, Aarthi Talla, Benigno Rodriguez, Carey Shive, Razvan Cristescu, Andrey Loboda, Robert Balderas, I-ming Wang, Peter Hunt, Daniel Lamarre, Daniel Douek, Daria Hazuda, Michael Lederman, Steven G. Deeks, Rafick-Pierre Sekaly
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45d665261ea5e4f7c82e64a7353a625
https://doi.org/10.2139/ssrn.4069031
https://doi.org/10.2139/ssrn.4069031