Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras.

Autor: Do TC; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Lau JW; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Sun C; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Liu S; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Kha KT; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore., Lim ST; Duke-NUS Medical School, Singapore 169857, Singapore.; Singapore Eye Research Institute, Singapore 169856, Singapore., Oon YY; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Kwan YP; Duke-NUS Medical School, Singapore 169857, Singapore.; Singapore Eye Research Institute, Singapore 169856, Singapore., Ma JJ; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore., Mu Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Liu X; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Carney TJ; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore., Wang X; Duke-NUS Medical School, Singapore 169857, Singapore.; Singapore Eye Research Institute, Singapore 169856, Singapore.; Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore., Xing B; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore.

Publikováno v: Science advances [Sci Adv] 2022 Dec 14; Vol. 8 (50), pp. eabq2216. Date of Electronic Publication: 2022 Dec 14.