Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kezhi Dai"'
Autor:
Chuanxin Huang, David G. Gonzalez, Christine M. Cote, Yanwen Jiang, Katerina Hatzi, Matt Teater, Kezhi Dai, Timothy Hla, Ann M. Haberman, Ari Melnick
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1497-1508 (2014)
To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2MUT mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses
Externí odkaz:
https://doaj.org/article/1ed162acc18c444ea8b0a2f5b7b9e0c9
Autor:
Kezhi Dai, M. Mahmood Hussain
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 901-908 (2012)
Regulation of microsomal triglyceride transfer protein (MTP) expression mainly occurs at the transcriptional level. We have previously shown that MTTP gene expression was repressed in nondifferentiated intestinal cells by nuclear receptor 2 family 1
Externí odkaz:
https://doaj.org/article/0a39e01db6204e768f297517f37a168b
Autor:
Yan, Hu, Kezhi, Dai
Publikováno v:
Advances in experimental medicine and biology. 1372
Sphingosine 1-phosphate (S1P) is a well-defined bioactive lipid molecule derived from membrane sphingolipid metabolism. In the past decades, a series of key enzymes involved in generation of S1P have been identified and characterized in detail, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0fb2aa00f8338aec202202f640a29a4
https://pubmed.ncbi.nlm.nih.gov/35503175
https://pubmed.ncbi.nlm.nih.gov/35503175
Autor:
Jahangir Iqbal, Manuel D. Suarez, Pradeep K. Yadav, Meghan T. Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M. Brickman, José A. Luchsinger, Kezhi Dai, Herman Moreno, M. Mahmood Hussain
Publikováno v:
Journal of Biological Chemistry. 298:102411
Sphingomyelin (SM) is an abundant plasma membrane and plasma lipoprotein sphingolipid. We previously reported that ATP-binding cassette family A protein 1 (ABCA1) deficiency in humans and mice decreases plasma SM levels. However, overexpression, indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b72b673a5e67deb7a0063a04f9a5a68
https://doi.org/10.1016/j.jbc.2022.102411
https://doi.org/10.1016/j.jbc.2022.102411
Autor:
Miaomiao Zheng, Wanchun Guan, Xulai Shi, Shao Wang, Yunbing Liu, Ming Duan, Minjie Ye, Manli Huang, Kezhi Dai, Xi Li, Kaiyu Guan, Aarti Kuver, Xianyong Zhou
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 223:115-123
Reserpine is widely used for treatment of hypertension and schizophrenia. As a specific inhibitor of monoamine transporters, reserpine is known to deplete monoamine neurotransmitters and cause decreased movement symptoms. However, how zebrafish larva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5dee8d55ab79a8ee34937154c4c762
https://doi.org/10.1016/j.cbpc.2019.05.008
https://doi.org/10.1016/j.cbpc.2019.05.008
Autor:
Xulai Shia, Wanshan Wang, Jia Li, Ting Wang, Yan Lin, Siqi Huang, Aarti Kuver, Chengshui Chen, Timothy Hla, Xi Li, Kezhi Dai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1866:130138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb1d1ce94f5850121a91dd5e274d570
https://doi.org/10.1016/j.bbagen.2022.130138
https://doi.org/10.1016/j.bbagen.2022.130138
Autor:
Beibei, Wang, Nian, Dong, Dengmin, Wu, Ya, Fang, Junjie, Chen, Yuting, Lin, Saverio, Bellusci, Jin-San, Zhang, Kezhi, Dai, Chengshui, Chen
Publikováno v:
Ann Transl Med
BACKGROUND: The sphingosine 1-phosphate (S1P)/S1P receptor (S1pr) 1 signaling plays an essential role in regulating vascular integrity and angiogenesis. We have previously shown that cell-surface expression of endoglin (Eng) is sustained by S1P/S1pr1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe8bc0868b45ba2154892f91021a3e0
https://doi.org/10.21037/atm-21-6679
https://doi.org/10.21037/atm-21-6679
Autor:
Beibei Wang, Danping Qiu, Jin-San Zhang, Chenjian Song, Kezhi Dai, Saverio Bellusci, Yani Yu, Dengmin Wu, Chengshui Chen
Publikováno v:
Mechanisms of lung injury and repair.
Signaling through Sphingosine-1-phosphate receptor 1 (S1PR1) contributes to maintain vascular integrity and stability. Bone morphogenetic 9 (BMP9) signaling through its associated co-receptor Endoglin was also identified as a vascular quiescence path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::515efd5006bc0e1ae9f37f26c2e6211f
https://doi.org/10.1183/13993003.congress-2019.pa3866
https://doi.org/10.1183/13993003.congress-2019.pa3866
Autor:
Siqi Huang, Chengshui Chen, Wanshan Wang, Xi Li, Xulai Shi, Jia Li, Aarti Kuver, Ting Wang, Kezhi Dai, Timothy Hla, Yan Lin
Publikováno v:
Biochimica et biophysica acta. General subjects. 1863(6)
The endothelial cell (EC) barrier disruption has been implicated in vascular leakage and pulmonary edema. Many reports have shown that the EC barrier dysfunction is regulated by the sphingosine-1-phophate (S1P)/S1P receptor-1 (S1PR1) axis. Identifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15cd97736cc2ceaffaa65755a7ff6ac
https://pubmed.ncbi.nlm.nih.gov/35501212
https://pubmed.ncbi.nlm.nih.gov/35501212
Autor:
Chengshui Chen, Xi Li, Youqun Xiang, Kezhi Dai, Zhongliang Chen, Dazhou Wu, Huandong Zhou, Xiaoming Chen, Huajing Ni, Shao Wang
Publikováno v:
Journal of Cellular and Molecular Medicine
Angiogenesis has a great impact on human health, owing to its participation in development, wound healing and the pathogenesis of several diseases. It has been reported that let‐7a is a tumour suppressor, but whether it plays a role in angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e02f126ddc642355ae2e640ddba02c1
https://pubmed.ncbi.nlm.nih.gov/30467960
https://pubmed.ncbi.nlm.nih.gov/30467960