Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kezhen Shen"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126278 (2015)
Cholestatic liver fibrosis was achieved by bile duct ligation (BDL) in mice. Liver injury associated with BDL for 15 days included significant reactive oxygen/nitrogen species generation, liver inflammation, cell death and fibrosis. Administration of
Externí odkaz:
https://doaj.org/article/e39ea2e2ba6c45419e7c88d9b657bd06
Autor:
Hao Pan, Jun Chen, Kezhen Shen, Xueping Wang, Ping Wang, Guanghou Fu, Hongzhou Meng, Yimin Wang, Baiye Jin
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124775 (2015)
Cancer chemotherapy drug cisplatin is known for its nephrotoxicity. The aim of this study is to investigate whether Epigallocatechin 3-Gallate (EGCG) can reduce cisplatin mediated side effect in kidney and to understand its mechanism of protection ag
Externí odkaz:
https://doaj.org/article/a9d7cfae10db4d8da75bee260bcd2be3
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86057 (2014)
Oxidative and nitrative stress is a well-known phenomenon in cisplatin-induced nephrotoxicity. The purpose of this work is to study the role of two metalloporphyrins (FeTMPyP and MnTBAP), water soluble complexes, in cisplatin-induced renal damage and
Externí odkaz:
https://doaj.org/article/0424151b124a4c20a262808e1350b7da
Autor:
Hao Pan, Kezhen Shen, Jiezhi Liao, Yimin Wang, Baiye Jin, Xiaoyi Chen, Taile Jing, Wenjun Tian, Zhijie Xu
Publikováno v:
Food and Chemical Toxicology. 129:108-114
Limitation of widely used anti-cancer agent cisplatin for a patient is nephrotoxicity. Nephrotoxicity is presentable in mice by injecting cisplatin at 25 mg/kg with 3 days endpoint. We used the same model to understand the protective role of urolithi
BackgrooundLung adenocarcinoma is one of the most common malignant lung cancers. Although platinum-based chemotherapy is the first-line adjuvant treatment for middle and late stage lung adenocarcinoma, the response of chemotherapy varies between pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35decd1127d70ea0a6ce99ff4a542795
https://doi.org/10.21203/rs.3.rs-54016/v1
https://doi.org/10.21203/rs.3.rs-54016/v1
Autor:
Wataru Fukuda, Xuan Huang, Jin-Woo Lee, Takaya Iida, Yoshito Itoh, Öykü Tayfur Yürekli, Hüseyin Köseoğlu, Eyüp Selvi, M. Román, F. Abad Santos, Mansheng Li, Aylin Demirezer Bolat, Yuji Naito, A. Algaba, Young-Joo Jin, Katsura Mizushima, Bin Lu, D. Ochoa, Daehyung Lee, Zhen Lv, Osman Ersoy, Kazuhiro Kamada, Lina Meng, Shin Il Kim, Jun Cheng, Sunyi Ye, Kezhen Shen, Seung Ho Lee, Murat Basaran, Hiroshi Ichikawa, J.P. Gisbert, Shusen Zheng, Semnur Buyukasik, Tomohisa Takagi, Mustafa Tahtacı, Don Haeng Lee, F. Bermejo, Fatma Ebru Akin, Kazuhiko Uchiyama, P.M. Linares, Jian Wu, I. Guerra, Kazuhiro Katada, Haifeng Jin, Şükran Erten, Jinfeng Dai, M. Chaparro, I. Moreno Arza, Druckerei Stückle, Yunsheng Qin, Chenxi Zhang, Osamu Handa, Xiaoyu Weng, Chen Hu
Publikováno v:
Digestion. 92:I-IV
Autor:
Sunyi Ye, Chen Hu, Mansheng Li, Zhen Lv, Jian Wu, Xiaoyu Weng, Chenxi Zhang, Shusen Zheng, Yunsheng Qin, Jun Cheng, Kezhen Shen
Publikováno v:
Digestion. 92:192-202
Aims: Hsp27, a master molecular chaperone, plays an important role in cancer. However, the specific co-chaperones that partner with Hsp27 and the role of Hsp27 in hepatocellular carcinoma (HCC) are not fully enumerated. The present study focuses on t
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Experimental cholestatic liver fibrosis was performed by bile duct ligation (BDL) in mice, and significant liver injury was observed in 15 days. Administration of baicalin in mice significantly ameliorates liver fibrosis. Experimental cholestatic liv
Autor:
Hongzhou Meng, Baiye Jin, Jie Shen, Zhijie Xu, Yiming Wang, Guanghou Fu, Hao Pan, Kezhen Shen
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Oxidative stress and inflammation are part and parcel of cisplatin-induced nephrotoxicity. The purpose of this work is to study the role of soy isoflavone constituent, daidzein, in cisplatin-induced renal damage. Cisplatin-induced nephrotoxicity was
Autor:
Hao Pan, Kezhen Shen, Haipeng Huang, Baiye Jin, Xiaoyi Chen, Ying Wang, Yuewei Jin, Zhijie Xu
Publikováno v:
Food and Chemical Toxicology. 131:110591
Kidney ischemia reperfusion injury (IRI) is an acute kidney injury associated with high number of mortality. We have examined the molecular mechanism and found that oxidative stress and hypoxia leads to induction of autophagy. In IRI induced autophag