Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Keyvan Keyvanfar"'
Autor:
Juan Pablo Ruiz, Guibin Chen, Juan Jesus Haro Mora, Keyvan Keyvanfar, Chengyu Liu, Jizhong Zou, Jeanette Beers, Hanan Bloomer, Husam Qanash, Naoya Uchida, John F. Tisdale, Manfred Boehm, Andre Larochelle
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
One of the most promising objectives of clinical hematology is to derive engraftable autologous hematopoietic stem cells (HSCs) from human induced pluripotent stem cells (iPSCs). Progress in translating iPSC technologies to the clinic relies on the a
Externí odkaz:
https://doaj.org/article/1b9b82545fe44b4484395f6db5b7fa07
Autor:
Prachi Jain, Jeffrey Klotz, Neil Dunavin, Kit Lu, Eleftheria Koklanaris, Debbie Draper, Jeanine Superata, Fariba Chinian, Quan Yu, Keyvan Keyvanfar, Susan Wong, Pawel Muranski, A. John Barrett, Sawa Ito, Minoo Battiwalla
Publikováno v:
Leukemia Research Reports, Vol 7, Iss C, Pp 40-44 (2017)
Patients with high risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) are commonly older with multiple co-morbidities, rendering them unsuitable for intensive induction chemotherapy or transplantation. We report preliminary cel
Externí odkaz:
https://doaj.org/article/2c3b912f606942a68f858e091e666190
Autor:
Zhijie Wu, Shouguo Gao, Xin Zhao, Jinguo Chen, Keyvan Keyvanfar, Xingmin Feng, Sachiko Kajigaya, Neal S. Young
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Long noncoding RNAs (lncRNAs) are regulators of cell differentiation and development. The lncRNA transcriptome in human hematopoietic stem and progenitor cells is not comprehensively defined. We investigated lncRNAs in 979 human bone marrow-derived C
Externí odkaz:
https://doaj.org/article/ab116a3eb14c4320ab3d6316d2ad977e
Autor:
Husam Qanash, Yongqin Li, Richard H. Smith, Kaari Linask, Sara Young-Baird, Waleed Hakami, Keyvan Keyvanfar, John S. Choy, Jizhong Zou, Andre Larochelle
Publikováno v:
Cells, Vol 10, Iss 4, p 734 (2021)
Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin synthesis, resulting in excess toxic free heme in erythroid progenitors, early differentiation a
Externí odkaz:
https://doaj.org/article/a092e388358d41e1be854e0b2763fc10
Autor:
Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale, Naoya Uchida
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/07b8e6884a6c45098aefde61ecdd133f
Autor:
Sawa Ito, A. John Barrett, Amalia Dutra, Evgenia Pak, Samantha Miner, Keyvan Keyvanfar, Nancy F. Hensel, Katayoun Rezvani, Pawel Muranski, Paul Liu, J. Joseph Melenhorst, Andre Larochelle
Publikováno v:
Stem Cell Research, Vol 14, Iss 1, Pp 95-104 (2015)
Mesenchymal stromal cells (MSCs) support the growth and differentiation of normal hematopoietic stem cells (HSCs). Here we studied the ability of MSCs to support the growth and survival of leukemic stem cells (LSCs) in vitro. Primary leukemic blasts
Externí odkaz:
https://doaj.org/article/def87c91c76d46f59ddf32fc482ed402
Autor:
Xingmin Feng, Zenghua Lin, Wanling Sun, Maile K. Hollinger, Marie J. Desierto, Keyvan Keyvanfar, Daniela Malide, Pawel Muranski, Jichun Chen, Neal S. Young
Publikováno v:
Haematologica, Vol 102, Iss 10 (2017)
Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients respond to immunosuppressive therapy, usually with anti-thymocyte globulin and cyclosporine,
Externí odkaz:
https://doaj.org/article/7917e96a806e40648342fd8c0c5a6d84
Autor:
Kazuya Sato, Xingmin Feng, Jichun Chen, Jungang Li, Pawel Muranski, Marie J. Desierto, Keyvan Keyvanfar, Daniela Malide, Sachiko Kajigaya, Neal S. Young
Publikováno v:
Haematologica, Vol 101, Iss 1 (2016)
Acquired aplastic anemia is an immune-mediated disease, in which T cells target hematopoietic cells; at presentation, the bone marrow is replaced by fat. It was reported that bone marrow adipocytes were negative regulators of hematopoietic microenvir
Externí odkaz:
https://doaj.org/article/11ae4f78ce3642a9870ccb0875c9f8d9
Autor:
Kohei Hosokawa, Pawel Muranski, Xingmin Feng, Keyvan Keyvanfar, Danielle M. Townsley, Bogdan Dumitriu, Jichun Chen, Sachiko Kajigaya, James G. Taylor, Christopher S. Hourigan, A. John Barrett, Neal S. Young
Publikováno v:
Haematologica, Vol 100, Iss 12 (2015)
Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated immune disease. Analysis of 84 microRNA expression levels in CD4+ and CD8+ T cells of patients
Externí odkaz:
https://doaj.org/article/380187048631475088f54287a744ddbc
Autor:
Valeria Visconte, Nalini Raghavachari, Delong Liu, Keyvan Keyvanfar, Marie J. Desierto, Jichun Chen, Neal S. Young
Publikováno v:
Haematologica, Vol 95, Iss 2 (2010)
Background Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria.Design and Methods We produced an animal mo
Externí odkaz:
https://doaj.org/article/4bb77a47a0ba4c2bbde739dd43b62f2d