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Abstract 3582: Differentiation of niraparib and olaparib brain penetration in a mouse brain metastatic tumor model

Autor: Mark Reid Groseclose, Jeremy Barry, Tinamarie Skedzielewski, Gerald McDermott, Chakravarthi Balabhadrapatruni, Bill Benson, Yongle Pang, David K. Lim, Hoang Tran, Mike Ringenberg, Keyur Gada, Amine Aziez, Elaine Paul, Hasan Alsaid

Publikováno v: Cancer Research. 83:3582-3582

Purpose: There remains an unmet need to provide effective treatment therapy for patients with primary and metastatic brain tumors; lack of drug penetration across the blood brain barrier (BBB) is a key factor. Synthetic lethality remains an attractiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eea5ac50d7f1ba10feffb709e146e17
https://doi.org/10.1158/1538-7445.am2023-3582

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Abstract 3581: Differentiation of niraparib and olaparib brain penetration in healthy rhesus macaque monkeys

Autor: Mark Reid Groseclose, Jeremy Barry, Yongle Pang, Jennifer Deutsch, Shannon Berry, Elaina McCormick, David K. Lim, Hoang Tran, Sean Maguire, Hasan Alsaid, Amine Aziez, Elaine Paul, Keyur Gada

Publikováno v: Cancer Research. 83:3581-3581

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7d72f536a6daa100effa99a8eb0f4a3
https://doi.org/10.1158/1538-7445.am2023-3581

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Tissue distribution and brain penetration of niraparib in tumor bearing mouse models and its clinical relevance

Autor: Elisabeth A. Minthorn, Tara L. Frenkl, Sebastien Hazard, Simon Roberts, Casey Kmett, Amine Aziez, Andrew Gehman, Dave Lugo, Giulia Fulci, Geeta Sharma, Keyur Gada

Publikováno v: Journal of Clinical Oncology. 39:e15066-e15066

e15066 Background: Cancer therapies that effectively cross the blood-brain barrier (BBB) to treat primary and metastatic brain tumors represent a critical unmet medical need. Brain metastasis are diagnosed in 10-40% of solid tumors and are associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::727f26b7312767bb26920408502c8bd1
https://doi.org/10.1200/jco.2021.39.15_suppl.e15066

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Imaging doxorubicin and polymer-drug conjugates of doxorubicin-induced cardiotoxicity with bispecific anti-myosin-anti-DTPA antibody and Tc-99m-labeled polymers

Autor: Ban-An Khaw, Prashant Bhattarai, Rajiv Panwar, Stan Majewski, Keyur Gada, Vishwesh Patil

Publikováno v: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 26(4)

Radiolabeled anti-myosin imaging is well-established for imaging doxorubicin-induced cardiotoxicity. However, to enable imaging of drug-induced cardiotoxicity in small experimental animals, pretargeting with bispecific anti-myosin-anti-DTPA-Fab-Fab�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4e7dd122732bd8f9a7fb2fdf2e5aa
https://pubmed.ncbi.nlm.nih.gov/29392625

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Bispecific antibody complex pre-targeting and targeted delivery of polymer drug conjugates for imaging and therapy in dual human mammary cancer xenografts

Autor: Stan Majewski, Andrew G. Weisenberger, Keyur Gada, Arash Hatefi, Savitri Mandapati, Ban-An Khaw, Vishwesh Patil, Rajiv Panwar

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 41:1603-1616

Doxorubicin, a frontline chemotherapeutic agent, limited by its cardiotoxicity and other tissue toxicities, was conjugated to N-terminal DTPA-modified polyglutamic acid (D-Dox-PGA) to produce polymer pro-drug conjugates. D-Dox-PGA or Tc-99 m labeled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2180596d0df00a7fd210d3671efbe2d7
https://doi.org/10.1007/s00259-014-2738-2

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Abstract 2952: Predicting concentration of PARP inhibitors in human tumor tissue using PBPK modeling

Autor: Linzhong Li, Yongchang Qiu, Keyur Gada, Rachel H. Rose, Jing Yu Wang, Kaiming Sun

Publikováno v: Cancer Research. 79:2952-2952

Poly (ADP-ribose) polymerase (PARP) inhibitors exert their effect intracellularly within tumor, thus sufficient tumor penetration is essential for a pharmacological response. Preclinical mouse xenograft data show a 3.3-fold higher tumor versus plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae3f587807574cc545ea94380b0df9eb
https://doi.org/10.1158/1538-7445.am2019-2952

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Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug conjugates

Autor: Keyur Gada, Yared Tekabe, Rajiv Panwar, Andrew G. Weisenberger, Alexandra D. Varvarigou, Vishwesh Patil, Craig F. Ferris, Stan Majewski, Ban-An Khaw

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 39:824-839

Pretargeting with bispecific monoclonal antibodies (bsMAb) for tumor imaging was developed to enhance target to background activity ratios. Visualization of tumors was achieved by the delivery of mono- and divalent radiolabeled haptens. To improve th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1e0987554abdaec1dddcdf02f03bbf
https://doi.org/10.1007/s00259-011-2050-3

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Bispecific antibody complex pre-targeted delivery of polymer–drug conjugates for cancer therapy

Autor: Rajiv Panwar, Keyur Gada, Arash Hatefi, Ban-An Khaw, Vishwesh Patil

Publikováno v: Drug Delivery and Translational Research. 2:65-76

The pretargeting approach using bispecific affibody-antibody complex (BAAC) and targeting of chemotherapeutic drug loaded polymers have been used in breast cancer cell cultures to demonstrate targeted chemotherapy and reduce toxicity to non-pretarget

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a5633cdcf24c1ab5252b7efa4e651
https://doi.org/10.1007/s13346-011-0055-x

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Abstract LB-069: In vivo delivery of asymmetric gene-silencing RNAs targeting CTNNB1 and PD-L1 show a broad spectrum of potent antitumor activities in preclinical cancer models

Autor: Wei Li, Jun Oishi, Chiang J. Li, Jie Su, Janet Huang, Xiaoshu Dai, Erina Koga, Emily Brooks, Ewa Wybieralska, Xiangao Sun, Yuan Gao, Eric Hsu, Keyur Gada, Youzhi Li, Yuxin Wang

Publikováno v: Cancer Research. 77:LB-069

RNAi (RNA interference) technology has the potential to target any genes causing disease, including conventionally “undruggable” targets in cancer. We previously discovered aiRNA (asymmetric interfering RNA), a next generation of gene-silencing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5931889a5306dfa62a6acbb39317e249
https://doi.org/10.1158/1538-7445.am2017-lb-069

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In vitro demonstration of enhanced prostate cancer toxicity: pretargeting with Bombesin bispecific complexes and targeting with polymer-drug-conjugates

Autor: Stan Majewski, Ban-An Khaw, Vishwesh Patil, Rajiv Panwar, Alexandra D. Varvarigou, Yared Tekabe, Keyur Gada

Publikováno v: Journal of drug targeting. 21(10)

Bombesin has been used to target Bombesin receptor, a growth receptor, which is over-expressed in many cancers, including prostate cancer. Polymer-anti-neoplastic-drug-conjugates (PDC) were also developed to reduce non-specific toxicity and increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e663114f7c9a0d6d4696cb273a0eb5
https://pubmed.ncbi.nlm.nih.gov/23863118

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