Výsledky vyhledávání - "Keyona N King"

Calcineurin A-α suppression drives nuclear factor-κB-mediated NADPH oxidase-2 upregulation

Autor: Robert S. Hoover, Heping P Ma, Yun Bai, Valerie Linck, Adaku C. Ume, Clintoria R. Williams, Keyona N King, Cynthia E Francis, Aswathy M Cheriyan, Hui Cai, Jennifer L. Gooch

Publikováno v: Am J Physiol Renal Physiol

Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the primary, catalytic calcineurin (CnA) isoforms are CnAα and CnAβ. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa454c03339475200e6df6ff3d7d5497
https://pubmed.ncbi.nlm.nih.gov/33615888

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Abstract 004: Caloric Restriction Prevents the Increase in Body Weight but not Hypertension in ALMS1 (Alström syndrome 1) Knockout Rat

Autor: Pablo A. Ortiz, Keyona N King-Medina

Publikováno v: Hypertension. 72

In humans, mutations in the ALMS1 gene cause obesity, diabetes and kidney disease. The mechanisms causing these alterations are unclear. We generated ALMS1 knockout (KO) rats in the Dahl salt-sensitive (SS) genetic background and found that ALMS1 KO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91b572bccc6035e0f92fc876f6e85827
https://doi.org/10.1161/hyp.72.suppl_1.004

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Abstract 103: Decreased Ability to Excrete a Na Load and Hypertension in the ALMS1 (Alstrom Syndrome 1) Knockout Rat

Autor: Keyona N King-Medina, Ankita B Jaykumar, Pablo A Ortiz

Publikováno v: Hypertension. 70

Few genes involved in obesity are known to be involved in hypertension. The Alstrom Syndrome 1 protein (ALMS1) is involved in obesity in humans. We found it is expressed in the thick ascending limb (TAL) where it interacts with the Na/K/2Cl cotranspo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::032f09f89f1374f0ec06d14381e66f13
https://doi.org/10.1161/hyp.70.suppl_1.103

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Role of Alström syndrome 1 in the regulation of blood pressure and renal function

Autor: Mariela Mendez, Dipak Maskey, Keyona N King-Medina, Indrani Datta, Juergen K Naggert, Pablo A. Ortiz, Paulo S. Caceres, William H. Beierwaltes, Ankita Bachhawat Jaykumar, Tang-Dong Liao

Publikováno v: JCI insight. 3(21)

Elevated blood pressure (BP) and renal dysfunction are complex traits representing major global health problems. Single nucleotide polymorphisms identified by genome-wide association studies have identified the Alström syndrome 1 (ALMS1) gene locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8715ce4da7d6a9f5e4f658ef9f9f5113
https://pubmed.ncbi.nlm.nih.gov/30443014

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Abstract 142: A Fructose-but Not a Glucose-enriched Diet, Induces a Salt-dependent Increase in Blood Pressure and Enhances NKCC2 Phosphorylation in Normal Rats

Autor: Keyona N King-Medina, Emily Henson, Pablo Ortiz

Publikováno v: Hypertension. 66

Human consumption of fructose as a sweetener has increased in the past 30 years. High fructose intake has been implicated in the development of hypertension, diabetes, and obesity. In the US, the upper 10th percentile of the population consumes up to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb30fa0abba6011d310eedc512643540
https://doi.org/10.1161/hyp.66.suppl_1.142

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