Výsledky vyhledávání - "Keyla Lazardi"

Antiproliferative Effects of △24(25) Sterol Methyl Transferase Inhibitors on Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo Studies

Autor: Gilberto Payares, Julio A. Urbina, Romano Piras, Julio Vivas, Keyla Lazardi, Judith Molina, Marta M. Pirns

Publikováno v: Chemotherapy. 42:294-307

We have studied the antiproliferative effects of two sterol analogs previously reported as potent inhibitors of Δ24(25) sterol methyl transferase (E.C. 2.1.1.43) of yeasts and fungi on epim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7d6c5540be2aa435927936d4cab9448
https://doi.org/10.1159/000239458

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Inhibition of phosphatidylcholine biosynthesis and cell proliferation in trypanosomacruzi by ajoene, an antiplatelet compound isolated from garlic

Autor: Marta M. Piras, Romano Piras, Edgar Marchán, Rafael Apitz-Castro, Tania Aguirre, Julio A. Urbina, Keyla Lazardi, Gonzalo Visbal, Francisco Gil

Publikováno v: Biochemical Pharmacology. 45:2381-2387

Ajoene [( E,Z )-4,5,9-trithiadodeca-1,6,11-triene 9-oxide], a potent antiplatelet compound derived from garlic, inhibits the proliferation of both epimastigotes and amastigotes of Trypanosoma cruzi , the causative agent of Chagas' disease. The growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c616a5941f9f7a03722c8cad35595e
https://doi.org/10.1016/0006-2952(93)90217-k

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Toward a novel metal-based chemotherapy against tropical diseases. 1. Enhancement of the efficacy of clotrimazole against Trypanosoma cruzi by complexation to ruthenium in RuCl2(clotrimazole)2

Autor: Alfred Noels, Luis Rincón, Keyla Lazardi, André J. Hubert, Roberto A. Sánchez-Delgado, Julio A. Urbina

Publikováno v: Journal of Medicinal Chemistry. 36:2041-2043

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f47972a05fb633a6702e4dfada3dd64
https://doi.org/10.1021/jm00066a014

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In-vitro antiproliferative effects and mechanism of action of the bis-triazole D0870 and its S(-) enantiomer against Trypanosoma cruzi

Autor: Andreina Liendo, Julio A. Urbina, Keyla Lazardi

Publikováno v: The Journal of antimicrobial chemotherapy. 41(2)

We investigated the in-vitro antiproliferative effects and mechanism of action of both enantiomers of the bis-triazole derivative ICI 195,739 against epimastigotes and amastigotes of Trypanosoma cruzi, the aetiological agent of Chagas' disease. It ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e923936b1efcfbc07b963cb533578ec
https://pubmed.ncbi.nlm.nih.gov/9533461

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Cure of short- and long-term experimental Chagas' disease using D0870

Autor: Norma Perez, Romano Piras, Patrick Wincker, Cristina Sanoja, Marta M. Piras, John F. Ryley, Keyla Lazardi, Judith Molina, Andreína Liendo, Gilberto Payares, Julio A. Urbina

Publikováno v: Science (New York, N.Y.). 273(5277)

Chagas9 disease, a protozoan infection by the kinetoplastid Trypanosoma cruzi, constitutes a major public health problem in Latin America. With the use of mouse models of both short- and long-term forms of the disease, the efficacy of D0870, a bis-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7485d3d23557556dead7e7fd38f5cc
https://pubmed.ncbi.nlm.nih.gov/8688084

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Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies

Autor: Keyla Lazardi, T Aguirre, G Payares, W. De Souza, Julio A. Urbina, Rosa A. Maldonado, Marta M. Piras, Gonzalo Visbal, Edgar Marchán, R Piras

Publikováno v: Antimicrobial agents and chemotherapy. 37(3)

We have studied the antiproliferative effects of mevinolin (lovastatin), an inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, on the protozoan parasite Trypanosoma (Schizotrypanum) cruzi and its ability to potentiate the action of specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796ff50993a2eac804c95acae62bebc0
https://pubmed.ncbi.nlm.nih.gov/8460926

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Toward a novel metal based chemotherapy against tropical diseases 4. Synthesis and characterization of new metal-clotrimazole complexes and evaluation of their activity against Trypanosoma cruzi

Autor: Dante Masi, Franklin Vargas, André Bouillez, Maribel Navarro, M. V. Capparelli, Reinaldo Atencio, Keyla Lazardi, Julio A. Urbina, Alfred F. Noels, Roberto A. Sánchez-Delgado

Publikováno v: Scopus-Elsevier

The syntheses and characterization of metal imidazole complexes showing activity against Trypanosoma cruzi, the causative agent of Chagas disease, are presented, RuCl2(CTZ)2 (2) and RuCl2(BTZ)2 (4) were prepared by reaction of RuCl2(NCCH3)4 (1) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a26d925215b4e531fe625cbd4522e47
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037972798&partnerID=MN8TOARS

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