Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Keykavous, Parang"'
Autor:
Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals th
Externí odkaz:
https://doaj.org/article/e6c1389e8b8c49e292af75e6afef5965
Autor:
Naiera M. Helmy, Keykavous Parang
Publikováno v:
Molecules, Vol 29, Iss 20, p 4951 (2024)
Peptide-based inhibitors represent a promising approach for the treatment of HIV-1, offering a range of potential advantages, including specificity, low toxicity, and the ability to target various stages of the viral lifecycle. This review outlines t
Externí odkaz:
https://doaj.org/article/add73f2c48674faeab133ab11b14f2a3
Autor:
Mrigank Shekhar Rai, Muhammad Imran Sajid, Jonathan Moreno, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1083 (2024)
Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery. To improve siRNA delivery and silence
Externí odkaz:
https://doaj.org/article/883e7669434d412c93e676034f3b8a6f
Publikováno v:
Antibiotics, Vol 13, Iss 6, p 555 (2024)
Antimicrobial peptides (AMPs) are being explored as a potential strategy to combat antibiotic resistance due to their ability to reduce susceptibility to antibiotics. This study explored whether the [R4W4] peptide mode of action is bacteriostatic or
Externí odkaz:
https://doaj.org/article/32536ee899f24b50b1e25a03379af779
Autor:
Shaima A. El-Mowafi, Anastasia G. Konshina, Eman H. M. Mohammed, Nikolay A. Krylov, Roman G. Efremov, Keykavous Parang
Publikováno v:
Molecules, Vol 28, Iss 24, p 8049 (2023)
In our ongoing quest to design effective antimicrobial peptides (AMPs), this study aimed to elucidate the mechanisms governing cyclic amphiphilic AMPs and their interactions with membranes. The objective was to discern the nature of these interaction
Externí odkaz:
https://doaj.org/article/4b70d63ae20e4b2db7dd629c475de2aa
Autor:
Jaunetta Hill, Karim E. Shalaby, Syed W. Bihaqi, Bothaina H. Alansi, Benjamin Barlock, Keykavous Parang, Richard Thompson, Khalid Ouararhni, Nasser H. Zawia
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15216 (2023)
The field of Alzheimer’s disease (AD) has witnessed recent breakthroughs in the development of disease-modifying biologics and diagnostic markers. While immunotherapeutic interventions have provided much-awaited solutions, nucleic acid-based tools
Externí odkaz:
https://doaj.org/article/9aed5ca525104b22a06f3a15bc960731
Autor:
Naiera M. Helmy, Keykavous Parang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 892 (2023)
Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial
Externí odkaz:
https://doaj.org/article/e78b1e3c26f44c309f8cc99d38244eb6
Autor:
Shilpi Gupta, Shang Eun Park, Saghar Mozaffari, Bishoy El-Aarag, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Molecules, Vol 28, Iss 10, p 4220 (2023)
The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore
Externí odkaz:
https://doaj.org/article/84d47a5915e54e7b9ab5eb45fc53e0dd
Autor:
Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, Keykavous Parang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 469 (2023)
The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins. Fmoc solid-phase peptide synt
Externí odkaz:
https://doaj.org/article/8ed404d83c3d4e97a568fff702784685
Autor:
Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
The Alzheimer’s brain is affected by multiple pathophysiological processes, which include a unique, organ-specific form of insulin resistance that begins early in its course. An additional complexity arises from the four-fold risk of Alzheimer’s
Externí odkaz:
https://doaj.org/article/7e5fc317f9164565a566660b6596922e