Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Keyi, Geng"'
Autor:
Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, Rajitha Indukuri, Joanne X Shen, Pablo Carravilla, Keyi Geng, Jonas Nørskov Søndergaard, Clàudia Ferrer-Aumatell, Grégoire Mercier, Erdinc Sezgin, Marion Korach-André, Carl Petersson, Hannes Hagström, Volker M Lauschke, Amena Archer, Cecilia Williams, Claudia Kutter
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 374-402 (2024)
Abstract Sex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver di
Externí odkaz:
https://doaj.org/article/ee239cfd60044f218b6abfe27eac0000
Autor:
Keyi Geng, Merino, Lara G., Veiga, Raül G., Sommerauer, Christian, Epperlein, Janine, Brinkman, Eva K., Kutter, Claudia
Publikováno v:
Life Science Alliance; Feb2024, Vol. 7 Issue 2, p1-15, 15p
Autor:
Tingting Zhang, Xiao Yang, Tengyuan Liu, Jiaxiang Shao, Ningzhen Fu, Aijuan Yan, Keyi Geng, Weiliang Xia
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-22 (2017)
Abstract Background Transplantation of neural stem cells (NSCs) has been proposed as a promising therapeutic strategy for the treatment of ischemia/reperfusion (I/R)-induced brain injury. However, existing evidence has also challenged this therapy on
Externí odkaz:
https://doaj.org/article/203e917c19d94842a27a665fb6aead33
Autor:
Keyi Geng, Lara G. Merino, Raül G. Veiga, Christian Sommerauer, Janine Epperlein, Eva K. Brinkman, Claudia Kutter
The CRISPR-Cas9 system is a powerful tool for studying gene functions and has tremendous potential for disease treatment. However, precise genome editing requires thorough assessments to minimize unintended on- and off-target effects. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1e325362adc4d8024e1a4a24b670427
https://doi.org/10.1101/2023.04.05.535680
https://doi.org/10.1101/2023.04.05.535680
Autor:
Donald P. Cameron, Jan Grosser, Swetlana Ladigan, Vladislav Kuzin, Evanthia Iliopoulou, Anika Wiegard, Hajar Benredjem, Sven T. Liffers, Smiths Lueong, Phyllis F. Cheung, Deepak Vangala, Michael Pohl, Richard Viebahn, Christian Teschendorf, Heiner Wolters, Selami Usta, Keyi Geng, Claudia Kutter, Marie Arsenian-Henriksson, Jens T. Siveke, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn, Laura Baranello
Pancreatic carcinoma is one of the most lethal cancers and the absence of efficient therapeutic strategies results in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC impacts initiation, development, and survival of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf901fd90d88257c9f0696f228c9e63e
https://doi.org/10.1101/2023.02.10.527824
https://doi.org/10.1101/2023.02.10.527824
Autor:
Jonas Nørskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, Giulia Guiducci, Lars Bräutigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan, Claudia Kutter
Publikováno v:
Gut. 71:2081-2092
ObjectiveTo better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs).DesignTo unravel RBP-lncRNA interactions in cancer, we
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
In response to stroke-induced injury, astrocytes can be activated and form a scar. Inflammation is an essential component for glial scar formation. Previous study has shown that adjudin, a potential Sirt3 activator, could attenuate lipopolysaccharide
Externí odkaz:
https://doaj.org/article/704ffffcc4b14c90bd300dd5997d20ca
Autor:
Keying Zhu, Yang Wang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris
Publikováno v:
Zhu, K, Wang, Y, Sarlus, H, Geng, K, Nutma, E, Sun, J, Kung, S-Y, Bay, C, Han, J, Min, J-H, Benito-Cuesta, I, Lund, H, Amor, S, Wang, J, Zhang, X-M, Kutter, C, Guerreiro-Cacais, A O, Högberg, B & Harris, R A 2022, ' Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation ', EMBO Reports, vol. 23, no. 7, e54499, pp. e54499 . https://doi.org/10.15252/embr.202154499
EMBO Reports, 23(7):e54499. Wiley-Blackwell
EMBO Reports, 23(7):e54499. Wiley-Blackwell
Targeting myeloid cells, especially microglia, for the treatment of neuroinflammatory diseases such as multiple sclerosis (MS), is underappreciated. Our in silico drug screening reveals topoisomerase 1 (TOP1) inhibitors as promising drug candidates f
Autor:
Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter
Publikováno v:
Genome research. 32(10)
The CRISPR-Cas9 system is widely used to permanently delete genomic regions via dual guide RNAs. Genomic rearrangements induced by CRISPR-Cas9 can occur, but continuous technical developments make it possible to characterize complex on-target effects
Publikováno v:
Cellular and Molecular Neurobiology. 41:1203-1215
Sirtuin 3 (Sirt3) is a member of the Sirtuin family proteins and known to regulate multiple physiological processes such as metabolism and aging. As stroke is an aging-related disease, in this work, we attempt to examine the role and potential mechan