Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Key H. Kim"'
Autor:
Byung Ho Lee, Key H. Kim, Kieyoung Chang, Young Woo Kim, Dae Kee Kim, Eunjoo Kim, Sung Jae Lee, Do Hyuan Ryu, Jae Jun Kim, Namkyu Lee, In Ho Jung, Hae In Rhee, Taek Soo Kim, Guang Jin Im, Keun Ho Ryu, Hwa Sup Shin
Publikováno v:
Arzneimittelforschung. 50:395-403
The general pharmacological properties of 2-amino-9-(3-acetoxymethyl-4-isopropoxycar-bonyloxybut-1-yl) purine (CAS 247081-81-8, SK 1899), a new potential antiviral agent, were investigated in mice, rats, guinea pigs, rabbits, and dogs. The oral admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985f32d822cf642e0026c9ce35861796
https://doi.org/10.1055/s-0031-1300220
https://doi.org/10.1055/s-0031-1300220
Autor:
Hunseung Yoo, Jin-A Jung, Wie-Jong Kwak, Dae-Kee Kim, Key H. Kim, Yong-Baik Cho, Young Bok Jung, Chang-Kyun Han, Kwon-Jae Roh, Kiwon Jung
Publikováno v:
The American Journal of Chinese Medicine. 29:485-491
SKI 306X is a purigied extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Prunella vulgaris) that have been widely used for the treatment of inflammatory diseases such as lymphadenitis and art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf0a8c27153d3a6236983b3d76cc112
https://doi.org/10.1142/s0192415x01000502
https://doi.org/10.1142/s0192415x01000502
Autor:
Key H. Kim, Dae Seog Heo, Tae-You Kim, Yung-Jue Bang, Noe Kyeong Kim, Dae-Kee Kim, Yong-Baik Cho, Jung Ae Lee, Young Iee Park, Sang-Goo Shin
Publikováno v:
Cancer. 91:1549-1556
BACKGROUND A Phase I study of cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) (SKI 2053R), a new platinum derivative, was performed to determine the maximum tolerated dose (MTD), the dose limiting toxicities (DLTs), and the phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3732b33a0cb66aa7cee7f835ea40972
https://doi.org/10.1002/1097-0142(20010415)91:8<1549::aid-cncr1164>3.0.co
https://doi.org/10.1002/1097-0142(20010415)91:8<1549::aid-cncr1164>3.0.co
Autor:
Kim Jae Sun, Young Seok Kim, Jun Won Lee, Young Woo Kim, Dae Kee Kim, Key H. Kim, Kieyoung Chang, Ki Seung Lee, Namkyu Lee
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:597-604
The synthesis of 14 C-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine from [1- 14 C] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9833c8f0f50e890cfa9464f015807079
https://doi.org/10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co
Publikováno v:
Journal of Medicinal Chemistry. 42:324-328
A series of 2-amino-9-(1,3-dihydroxy-2-propoxymethyl)-6-fluoropurin mono- and diesters, 6a-h, were synthesized as potential prodrugs of ganciclovir and evaluated for their oral ganciclovir bioavailability in rats. Treatment of 2-amino-6-chloro-9-(1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1717492d1ffb56c7651a8d876934615a
https://doi.org/10.1021/jm980321+
https://doi.org/10.1021/jm980321+
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:2525-2530
2-Amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine (2) and its ester derivatives 4a-d were synthesized as potential prodrugs of acyclovir, and were evaluated for their oral acyclovir bioavailability in rats and in vivo antiviral efficacy in HSV-1-infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6878e95cea3cc330d834865ce66bc5
https://doi.org/10.1016/s0968-0896(98)80026-6
https://doi.org/10.1016/s0968-0896(98)80026-6
Autor:
Yong Baik Cho, Taek Soo Kim, Dae Seog Heo, Yung-Jue Bang, Key H. Kim, Hun Taek Kim, Sang Goo Shin, Dae Kee Kim, In-Ho Jung, Noe Kyeong Kim
Publikováno v:
Cancer Chemotherapy and Pharmacology. 41:109-116
The effect of exposure time on the in vitro cytotoxicity of a new platinum complex, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolan e]platinum(II) (SKI 2053R) and cisplatin (CDDP) toward two human lung-adenocarcinoma cell lines (PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9cad3168bb6f9d4fe19cd64e448f82
https://doi.org/10.1007/s002800050716
https://doi.org/10.1007/s002800050716
Publikováno v:
Journal of Medicinal Chemistry. 40:2363-2373
A series of 1-alkoxy-5-alkyl-6-(arylthio)uracils was synthesized and tested for their ability to inhibit HIV-1 replication. Treatment of 2-alkyl-3,3-bis(methylthio)acryloyl chlorides (5a-e) with AgOCN in benzene followed by reaction of the resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38c6e98cf180efc244bd6107c2d7d79
https://doi.org/10.1021/jm9607921
https://doi.org/10.1021/jm9607921
Publikováno v:
Journal of Heterocyclic Chemistry. 34:659-663
A new route to C-6-selenenyl analogs of compound 1a from 5-alkyl-6-chlorouracils 6a-b has been described. A mild and highly efficient synthesis of 1-(alkoxymethyl)-5-alkyl-6-(arylselenenyl)uracils 8a-e has been accomplished from 6a-b in good yields u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ead1ed03508bd2dbc3fdd1eae3c60f
https://doi.org/10.1002/jhet.5570340252
https://doi.org/10.1002/jhet.5570340252
Publikováno v:
Journal of Heterocyclic Chemistry. 34:311-314
Synthesis of 6-substituted 1-alkoxy-5-alkyluracils 2a-c have been achieved from readily accessible 2-alkyl-3,3-di(methylthio)acryloyl chlorides 4a,b in high overall yields. Treatment of 4a,b with silver cyanate followed by reaction of the resulting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deea3a725b25278aad9c455c62d25903
https://doi.org/10.1002/jhet.5570340148
https://doi.org/10.1002/jhet.5570340148