Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kewen Qian"'
Autor:
Guangyao Li, Shuyi Zhang, Yitan Zou, Hongru Ai, Xinya Zheng, Kewen Qian, Changhai Lei, Wenyan Fu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exosomes are found in various tissues of the body and carry abundant contents including nucleic acids, proteins, and metabolites, which continuously flow between cells of various tissues and mediate important intercellular communication. In addition,
Externí odkaz:
https://doaj.org/article/3647f5f043cc4c04a6486fb7b0d6f46d
Autor:
Kewen Qian, Guangyao Li, Shuyi Zhang, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei, Yuqing Wang, Shi Hu
Publikováno v:
Interdisciplinary Medicine, Vol 2, Iss 2, Pp n/a-n/a (2024)
Abstract T cells engineered to express chimeric antigen receptors (CARs) with specificity toward tumor cells have led to promising outcomes in patients with hematological malignancies. Nevertheless, the application of CAR‐T cell therapy in solid tu
Externí odkaz:
https://doaj.org/article/62a2624a1f6f428e8414a5204bf53df5
Autor:
Xinya Zheng, Hongru Ai, Kewen Qian, Guangyao Li, Shuyi Zhang, Yitan Zou, Changhai Lei, Wenyan Fu, Shi Hu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exosomes are small extracellular vesicles (sEVs) secreted by cells. With advances in the study of sEVs, they have shown great potential in the diagnosis and treatment of disease. However, sEV therapy usually requires a certain dose and purity of sEVs
Externí odkaz:
https://doaj.org/article/3e7f784a43124559bef03456e9d1cf67
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-29 (2022)
Abstract Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracellular vesicles (sEVs) are defined
Externí odkaz:
https://doaj.org/article/8351bc924da84f8e95b41d1842c17577
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
SARS coronavirus 2 (SARS-CoV-2) invades the human body by binding to major receptors such as ACE2 via its S-spike protein, so the interaction of receptor-binding sites has been a hot topic in the development of coronavirus drugs. At present, the clin
Externí odkaz:
https://doaj.org/article/be4029ac039e41f7b7de382f4eaeccfa
Publikováno v:
View, Vol 3, Iss 2, Pp n/a-n/a (2022)
Abstract The world is experiencing one of the most difficult moments in history with COVID‐19, which has rapidly developed into a worldwide pandemic with a significant health and economic burden. Efforts to fight the virus, including prevention and
Externí odkaz:
https://doaj.org/article/50d10d3ed0ae45239adf6a7ff25b866c
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to AC
Externí odkaz:
https://doaj.org/article/3b3d05e197724b28bed5fc76756f4d1d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Targeted therapeutics for the treatment of coronavirus disease 2019 (COVID-19), especially severe cases, are currently lacking. As macrophages have unique effector functions as a first-line defense against invading pathogens, we genetically armed hum
Externí odkaz:
https://doaj.org/article/ba14d9fa755a49ab9f4d97f6bf37972e
Autor:
Wenyan Fu, Changhai Lei, Shuowu Liu, Yingshu Cui, Chuqi Wang, Kewen Qian, Tian Li, Yafeng Shen, Xiaoyan Fan, Fangxing Lin, Min Ding, Mingzhu Pan, Xuting Ye, Yongji Yang, Shi Hu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells
Externí odkaz:
https://doaj.org/article/9922d9f362cb422ca19401f860eaed83
Autor:
Kewen Qian, Shi Hu
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. In contrast, Ig-like ACE2 fusion
Externí odkaz:
https://doaj.org/article/fbdf7bbc8fcf4cc099d7c2154f679558