Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kewen Hu"'
Autor:
Juanjuan Feng, Zhengke Lian, Xinting Xia, Yue Lu, Kewen Hu, Yunpeng Zhang, Yanan Liu, Longmiao Hu, Kun Yuan, Zhenliang Sun, Xiufeng Pang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1145-1163 (2023)
MEK is a canonical effector of mutant KRAS; however, MEK inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant cancers. Here, we identified mitochondrial oxidative phosphorylation (OXPHOS) induction as a profound metabolic alteration
Externí odkaz:
https://doaj.org/article/330cb01aa91d4b50ae4c436b870a5b24
Autor:
Kun Li, Yanan Liu, Yi Ding, Zhengwei Zhang, Juanjuan Feng, Jiaxin Hu, Jiwei Chen, Zhengke Lian, Yiliang Chen, Kewen Hu, Zhi Chen, Zhenyu Cai, Mingyao Liu, Xiufeng Pang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer. BCL6 expression was increased upon KRAS activati
Externí odkaz:
https://doaj.org/article/af61bce617fb4998b7196414b047c45d
Autor:
Jieqiong Wang, Kewen Hu, Jiawei Guo, Feixiong Cheng, Jing Lv, Wenhao Jiang, Weiqiang Lu, Jinsong Liu, Xiufeng Pang, Mingyao Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition
Externí odkaz:
https://doaj.org/article/0c74c6b0573c4f9f816fe66db2394a14
Autor:
Yuting Guan, Yanlin Ma, Qi Li, Zhenliang Sun, Lie Ma, Lijuan Wu, Liren Wang, Li Zeng, Yanjiao Shao, Yuting Chen, Ning Ma, Wenqing Lu, Kewen Hu, Honghui Han, Yanhong Yu, Yuanhua Huang, Mingyao Liu, Dali Li
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 477-488 (2016)
Abstract The X‐linked genetic bleeding disorder caused by deficiency of coagulator factor IX, hemophilia B, is a disease ideally suited for gene therapy with genome editing technology. Here, we identify a family with hemophilia B carrying a novel m
Externí odkaz:
https://doaj.org/article/0797499433c942ec877aba02b8679386
Autor:
Wenjuan Li, Fushun Liang, Xiucai Sun, Kangyi Zheng, Ruojuan Liu, Hao Yuan, Shuting Cheng, Jingnan Wang, Yi Cheng, Kewen Huang, Kun Wang, Yuyao Yang, Fan Yang, Ce Tu, Xinyu Mao, Wanjian Yin, Ali Cai, Xiaobai Wang, Yue Qi, Zhongfan Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Graphene growth on widely used dielectrics/insulators via chemical vapor deposition (CVD) is a strategy toward transfer-free applications of CVD graphene for the realization of advanced composite materials. Here, we develop graphene-skinned
Externí odkaz:
https://doaj.org/article/bc6f7c27a8af424a9e98dd6d66d78300
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Increased selenium (Se) content in fruits can supply Se in human body, but the effects of teas on the Se uptake in fruit trees are unknown. The effects of infusions of four teas (green, black, dark, and white) on the Se uptake of grapevine w
Externí odkaz:
https://doaj.org/article/b28cd58baad84600aced62c00f8699cb
Autor:
Kun Wang, Xiucai Sun, Shuting Cheng, Yi Cheng, Kewen Huang, Ruojuan Liu, Hao Yuan, Wenjuan Li, Fushun Liang, Yuyao Yang, Fan Yang, Kangyi Zheng, Zhiwei Liang, Ce Tu, Mengxiong Liu, Mingyang Ma, Yunsong Ge, Muqiang Jian, Wanjian Yin, Yue Qi, Zhongfan Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Direct chemical vapor deposition (CVD) growth of graphene on dielectric/insulating materials is a promising strategy for subsequent transfer-free applications of graphene. However, graphene growth on noncatalytic substrates is faced with tho
Externí odkaz:
https://doaj.org/article/e321ef22afb24efcb9b3842ed2d5299a
Publikováno v:
New Carbon Materials. 35:444-451
Nitrogen-doped graphene ink is still not perfect for printing because of its low concentration, many defects, and easy agglomeration, limiting its use in functional printing devices. To solve these problems, nitrogen-doped graphene (NG) was prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073fa5a13b9aaa9ced6c343f587c21a3
https://doi.org/10.1016/s1872-5805(20)60502-9
https://doi.org/10.1016/s1872-5805(20)60502-9
Autor:
Wenhao Jiang, Haixiang Pei, Jing Chen, Feixiong Cheng, Zhenyu Cai, Kun Li, Xiufeng Pang, Haigang Wu, Yihua Chen, Jie Feng, Mingyao Liu, Kewen Hu, Jing Lv, Paul J. Chiao, Jieqiong Wang
Publikováno v:
J Clin Invest
Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6724fa7e859a3bc8ba513e3b2d9e8d
https://doi.org/10.1172/jci124049
https://doi.org/10.1172/jci124049
Publikováno v:
Applied Surface Science. 473:614-621
Uniform nitrogen-doped graphene lines with favorable outlines are essential components for graphene-based functional devices. However, the line instability in the droplet printing process would deteriorate the straightness and uniformity of printed l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::893b11d8332f47ffdc0f6fc26baf1a70
https://doi.org/10.1016/j.apsusc.2018.12.176
https://doi.org/10.1016/j.apsusc.2018.12.176