d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia

Autor: Verrall, L, Walker, M, Rawlings, N, Benzel, I, Kew, JN, Harrison, PJ, Burnet, PW

Publikováno v: The European Journal of Neuroscience

The N-methyl-D-aspartate receptor co-agonist d-serine is synthesized by serine racemase and degraded by D-amino acid oxidase. Both D-serine and its metabolizing enzymes are implicated in N-methyl-D-aspartate receptor hypofunction thought to occur in

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http://europepmc.org/articles/PMC2121142

Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.

Autor: Petit EI; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Michalak Z; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK., Cox R; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Tuathaigh CM; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; School of Medicine, University College Cork, Cork, Ireland., Clarke N; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Office of Research and Innovation, Royal College of Surgeons in Ireland, Dublin, Ireland., Tighe O; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Talbot K; Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA., Blake D; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Joel J; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.; Horizon Discovery, Cambridge, UK., Shaw A; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK., Sheardown SA; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.; Takeda Cambridge, Cambridge, UK., Morrison AD; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.; Worldwide Business Development, GlaxoSmithKline, Stevenage, UK., Wilson S; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.; Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, UK., Shapland EM; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK., Henshall DC; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Kew JN; Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK., Kirby BP; School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland., Waddington JL; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Jiangsu Key Laboratory of Translational Research & Therapy for Neuro-Psychiatric-Disorders and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2017 May; Vol. 42 (6), pp. 1349-1360. Date of Electronic Publication: 2016 Dec 16.

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.

Autor: Davies DJ; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK., Crowe M, Lucas N, Quinn J, Miller DD, Pritchard S, Grose D, Bettini E, Calcinaghi N, Virginio C, Abberley L, Goldsmith P, Michel AD, Chessell IP, Kew JN, Miller ND, Gunthorpe MJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Apr 01; Vol. 22 (7), pp. 2620-3. Date of Electronic Publication: 2012 Feb 06.

Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus.

Autor: Ondrejcak T; Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin 2, Ireland., Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2012 Feb 29; Vol. 677 (1-3), pp. 63-70. Date of Electronic Publication: 2011 Dec 16.

Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.

Autor: Lyon L; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Borel M, Carrión M, Kew JN, Corti C, Harrison PJ, Burnet PW, Paulsen O, Rodríguez-Moreno A

Publikováno v: Synapse (New York, N.Y.) [Synapse] 2011 Sep; Vol. 65 (9), pp. 945-54. Date of Electronic Publication: 2011 Mar 28.