Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevser Biberoglu"'
Publikováno v:
Molecules, Vol 25, Iss 3, p 533 (2020)
A newly recognized action of organophosphates (OP) is the ability to crosslink proteins through an isopeptide bond. The first step in the mechanism is covalent addition of the OP to the side chain of lysine. This activates OP-lysine for reaction with
Externí odkaz:
https://doaj.org/article/21c08762431a40babeb7a94c70a163a4
Publikováno v:
Drug Development Research. 83:900-909
Amyloid precursor-like protein-2 (APLP2) and its C-terminal fragments (CTFs) are expressed at high levels in pancreatic cancer cells and knockdown of APLP2 expression inhibits tumor growth. CTFs are released from APLP2 by beta-secretase (BACE). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6320a3634c74f0b665f5a36bcf7026
https://doi.org/10.1002/ddr.21915
https://doi.org/10.1002/ddr.21915
Publikováno v:
Chemico-biological interactions. 366
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of amyloid-β peptide (Aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. Most of the FDA-approved AD drugs cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0004839b1b627a021f0965162bcdf5ec
https://pubmed.ncbi.nlm.nih.gov/36027949
https://pubmed.ncbi.nlm.nih.gov/36027949
Publikováno v:
Chemico-biological interactions. 363
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer's patients. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e286484a29865b13aac21a58950161
https://pubmed.ncbi.nlm.nih.gov/35779611
https://pubmed.ncbi.nlm.nih.gov/35779611
Autor:
Kevser Biberoglu
Publikováno v:
Volume: 8, Issue: 2 435-442
Journal of the Turkish Chemical Society Section A: Chemistry
Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 2, Pp 435-442 (2021)
Journal of the Turkish Chemical Society Section A: Chemistry
Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 2, Pp 435-442 (2021)
Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder, characterized by β-amyloid plaques, neurofibrillary tangles and loss of cholinergic neurons. Butyrylcholinesterase (BChE) inhibition is one of the most critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05df6a190fc34eb79b0268aebe7f8188
https://dergipark.org.tr/tr/pub/jotcsa/issue/60129/853598
https://dergipark.org.tr/tr/pub/jotcsa/issue/60129/853598
Publikováno v:
Anal Biochem
Glutamine residues susceptible to transglutaminase-catalyzed crosslinking can be identified by incorporation of dansyl cadaverine or biotin cadaverine. Bacterial transglutaminase and human transglutaminase 2 were used to modify residues in beta-casei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f791252b91b2e53b4949d8f1f0b2318
https://europepmc.org/articles/PMC7302536/
https://europepmc.org/articles/PMC7302536/
Alzheimer's disease (AD), the most common form of dementia, is characterized by abundant deposition of amyloid-beta (A beta) peptide that is the result of sequential cleavage of amyloid precursor protein (APP) by beta-secretase and gamma-secretase. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f53b90669f958a810ab0145073187
https://aperta.ulakbim.gov.tr/record/68631
https://aperta.ulakbim.gov.tr/record/68631
Publikováno v:
Molecules
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 533 (2020)
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 533 (2020)
A newly recognized action of organophosphates (OP) is the ability to crosslink proteins through an isopeptide bond. The first step in the mechanism is covalent addition of the OP to the side chain of lysine. This activates OP-lysine for reaction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220e8aaad51e39efe9700f1054f2681
https://doi.org/10.3390/molecules25030533
https://doi.org/10.3390/molecules25030533
Recently, we have demonstrated that toluidine blue O (TBO), a phenothiazine dye, shows inhibitory effects on both cholinesterases and amyloid pathology in Alzheimer's disease (AD) cellular model. In the present study, we aimed to determine the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c09fa4adcdfd1ac893809a30cabdb3
https://aperta.ulakbim.gov.tr/record/37007
https://aperta.ulakbim.gov.tr/record/37007
The excess accumulation of amyloid-beta (A beta) peptides derived from the sequential cleavage of amyloid precursor protein (APP) by secretases, is one of the toxic key events leading to neuronal loss in Alzheimer's disease (AD). Studies have shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b515a62c0e0e9ab1f16a16a9f45b5a68
https://avesis.gazi.edu.tr/publication/details/622f4dd5-8e58-4a15-b535-11f23a1d4f5b/oai
https://avesis.gazi.edu.tr/publication/details/622f4dd5-8e58-4a15-b535-11f23a1d4f5b/oai