Zobrazeno 1 - 4
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pro vyhledávání: '"Kevin eMcNally"'
Autor:
Kevin eMcNally, George D Loizou
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
The risk assessment of environmental chemicals and drugs is undergoing a paradigm shift in approach which seeks the full replacement of animal testing with high throughput, mechanistic, in vitro systems. This new approach will be reliant on the measu
Externí odkaz:
https://doaj.org/article/6522ba1757cb4f18b1b8045bfd31f9e7
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those paramete
Externí odkaz:
https://doaj.org/article/60010d24e2c443ceabc2056b9c760d0c
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quan
Externí odkaz:
https://doaj.org/article/cf2901a5668f4f0193c2aafaeb76a43b
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2011)
Physiologically based pharmacokinetic models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data c
Externí odkaz:
https://doaj.org/article/2b144c61ef6d452dbea2a1a07f9a3154