A proof-of-concept study for the pathogenetic role of enhancer hypomethylation of MYBPHL in multiple myeloma

Autor: Kwan Yeung Wong, Gareth J. Morgan, Eileen M. Boyle, Alfred Sze Lok Cheng, Kevin Yuk-Lap Yip, Chor Sang Chim

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Enhancer DNA methylation and expression of MYBPHL was studied in multiple myeloma (MM). By bisulfite genomic sequencing, among the three CpGs inside the MYBPHL enhancer, CpG1 was significantly hypomethylated in MM cell lines (6.7–50.0%) th

Externí odkaz: https://doaj.org/article/d58c3083d67245f89af33385adaad2f0

Nonalbuminuric Diabetic Kidney Disease and Risk of All-Cause Mortality and Cardiovascular and Kidney Outcomes in Type 2 Diabetes: Findings From the Hong Kong Diabetes Biobank

Autor: Qiao Jin, Andrea O. Luk, Eric S.H. Lau, Claudia H.T. Tam, Risa Ozaki, Cadmon K.P. Lim, Hongjiang Wu, Guozhi Jiang, Elaine Y.K. Chow, Jack K. Ng, Alice P.S. Kong, Baoqi Fan, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y. Leung, Man-wo Tsang, Grace Kam, Ip Tim Lau, June K. Li, Vincent T. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Yu Huang, Hui-yao Lan, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan, Ronald C.W. Ma, Cadmon King Poo Lim, Jenny Y.Y. Leung, Man Wo Tsang, Elaine Cheung, June Kam-yin Li, Vincent T.F. Yeung, Samuel K.S. Fung, Stephen Kwok-wing Tsui, Weichuan Yu, Brian Tomlinson, Si Lok, Ting Fung Chan, Kevin Yuk-lap Yip, Xiaodan Fan, Nelson L.S. Tang, Xiaoyu Tian, Shi Mai, Eric S. Lau, Fei Xie, Sen Zhang, Pu Yu, Meng Wang, Heung Man Lee, Fangying Xie, Alex C.W. Ng, Grace Cheung, Ming Wai Yeung, Kitty K.T. Cheung, Rebecca Y.M. Wong, So Hon Cheong, Katie K.H. Chan, Chin-san Law, Anthea Ka Yuen Lock, Ingrid Kwok Ying Tsang, Susanna Chi Pun Chan, Yin Wah Chan, Cherry Chiu, Chi Sang Hung, Cheuk Wah Ho, Ivy Hoi Yee Ng, Juliana Mun Chun Fok, Kai Man Lee, Hoi Sze Candy Leung, Ka Wah Lee, Hui Ming Chan, Winnie Wat, Tracy Lau, Rebecca Law, Ryan Chan, Candice Lau, Pearl Tsang, Vince Chan, Lap Ying Ho, Eva Wong, Josephine Chan, Sau Fung Lam, Jessy Pang, Yee Mui Lee

Publikováno v: American Journal of Kidney Diseases. 80:196-206.e1

Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing DKD phenotype. We compared the risks of adverse outcomes among patients with this phenotype compared with other DKD phenotypes.Multicenter prospective cohort study.19,025 Chinese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7999dd7b6ed37fd37012f60506d91f7f
https://doi.org/10.1053/j.ajkd.2021.11.011

Abstract 4352: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis

Autor: Steve Tin-Chi Luk, Man Tong, Kai Yu Ng, Kevin Yuk-Lap Yip, Xin Yuan Guan, Stephanie Ma

Publikováno v: Cancer Research. 77:4352-4352

The existence of a cancer stem cell (CSCs) subset is well established in hepatocellular carcinoma (HCC). This subset can be characterized by its CD133 expression. Since the discovery of this marker, studies have revealed deregulated pathways and epig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::933e38805c72a98089251ebc7b8688e3
https://doi.org/10.1158/1538-7445.am2017-4352