The breath shape controls intonation of mouse vocalizations

Autor: Alastair MacDonald, Alina Hebling, Xin Paul Wei, Kevin Yackle

Publikováno v: eLife, Vol 13 (2024)

Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct sounds with different denotations, like in

Externí odkaz: https://doaj.org/article/f0e8ae462313483291acc939c839a3a2

Opioids depress breathing through two small brainstem sites

Autor: Iris Bachmutsky, Xin Paul Wei, Eszter Kish, Kevin Yackle

Publikováno v: eLife, Vol 9 (2020)

The rates of opioid overdose in the United States quadrupled between 1999 and 2017, reaching a staggering 130 deaths per day. This health epidemic demands innovative solutions that require uncovering the key brain areas and cell types mediating the c

Externí odkaz: https://doaj.org/article/5e3790b104ee49f4ae43c67e30ee7a98

Discovery-based science education: functional genomic dissection in Drosophila by undergraduate researchers.

Autor: Jiong Chen, Gerald B Call, Elsa Beyer, Chris Bui, Albert Cespedes, Amy Chan, Jenny Chan, Stacy Chan, Akanksha Chhabra, Peter Dang, Artemis Deravanesian, Brenda Hermogeno, James Jen, Eunha Kim, Eric Lee, Gemma Lewis, Jamie Marshall, Kirsten Regalia, Farnaz Shadpour, Aram Shemmassian, Kristin Spivey, Maggie Wells, Joy Wu, Yuki Yamauchi, Amir Yavari, Anna Abrams, Amanda Abramson, Latiffe Amado, Jenny Anderson, Keenan Bashour, Elena Bibikova, Allen Bookatz, Sarah Brewer, Natalie Buu, Stephanie Calvillo, Joseph Cao, Aileen Chang, Daniel Chang, Yuli Chang, Yibing Chen, Joo Choi, Jeyling Chou, Sumit Datta, Ardy Davarifar, Poonam Desai, Jordan Fabrikant, Shahbaz Farnad, Katherine Fu, Eddie Garcia, Nick Garrone, Srpouhi Gasparyan, Phyllis Gayda, Chad Goffstein, Courtney Gonzalez, Mariam Guirguis, Ryan Hassid, Aria Hong, Julie Hong, Lindsay Hovestreydt, Charles Hu, Farid Jamshidian, Katrin Kahen, Linda Kao, Melissa Kelley, Thomas Kho, Sarah Kim, Yein Kim, Brian Kirkpatrick, Emil Kohan, Robert Kwak, Adam Langenbacher, Santino Laxamana, Chris Lee, Janet Lee, So-Youn Lee, To Hang S Lee, Toni Lee, Sheila Lezcano, Henry Lin, Peter Lin, Julie Luu, Thanh Luu, Will Marrs, Erin Marsh, Sarah Min, Tanya Minasian, Amit Misra, Miles Morimoto, Yasaman Moshfegh, Jessica Murray, Cynthia Nguyen, Kha Nguyen, Ernesto Nodado, Amanda O'Donahue, Ndidi Onugha, Nneka Orjiakor, Bhavin Padhiar, Mara Pavel-Dinu, Alex Pavlenko, Edwin Paz, Sarah Phaklides, Lephong Pham, Preethi Poulose, Russell Powell, Aya Pusic, Divi Ramola, Meghann Ribbens, Bassel Rifai, Desiree Rosselli, Manyak Saakyan, Pamela Saarikoski, Miriam Segura, Ramnik Singh, Vivek Singh, Emily Skinner, Daniel Solomin, Kosha Soneji, Erika Stageberg, Marina Stavchanskiy, Leena Tekchandani, Leo Thai, Jayantha Thiyanaratnam, Maurine Tong, Aneet Toor, Steve Tovar, Kelly Trangsrud, Wah-Yung Tsang, Marc Uemura, Mary Unkovic, Emily Vollmer, Emily Weiss, Damien Wood, Sophia Wu, Winston Wu, Qing Xu, Kevin Yackle, Will Yarosh, Laura Yee, George Yen, Grant Alkin, Sheryllene Go, Devon M Huff, Helena Minye, Eric Paul, Nikki Villarasa, Allison Milchanowski, Utpal Banerjee

Publikováno v: PLoS Biology, Vol 3, Iss 2, p e59 (2005)

Externí odkaz: https://doaj.org/article/7b4a754936624132b088826fcc3c74bb

A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing

Autor: Xin Paul Wei, Matthew Collie, Bowen Dempsey, Gilles Fortin, Kevin Yackle

Publikováno v: Neuron, vol 110, iss 4
Neuron
Neuron, 2022, 110 (4), pp.644-657.e6. ⟨10.1016/j.neuron.2021.12.014⟩

International audience; Human speech can be divided into short, rhythmically timed elements, similar to syllables within words. Even our cries and laughs, as well as the vocalizations of other species, are periodic. However, the cellular and molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41da908e38c668de0ac7c1eb5182d6c6
https://escholarship.org/uc/item/6nn929cd

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

Autor: Xin Paul Wei, Adelae Durand, Iris Bachmutsky, Kevin Yackle

Publikováno v: eLife, Vol 10 (2021)
eLife

Opioids are perhaps the most effective analgesics in medicine. However, between 1999 and 2018, over 400,000 people in the United States died from opioid overdose. Excessive opioids make breathing lethally slow and shallow, a side-effect called opioid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ea6197903902570178f702e5d8756d
https://elifesciences.org/articles/62552