Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Kevin Y. Yip"'
Autor:
Wenyu Chen, Chen Miao, Zhenghao Zhang, Cathy Sin-Hang Fung, Ran Wang, Yizhen Chen, Yan Qian, Lixin Cheng, Kevin Y. Yip, Stephen Kwok-Wing Tsui, Qin Cao
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract The precision-recall curve (PRC) and the area under the precision-recall curve (AUPRC) are useful for quantifying classification performance. They are commonly used in situations with imbalanced classes, such as cancer diagnosis and cell typ
Externí odkaz:
https://doaj.org/article/72b3cb2ca13a40edbd413de430bceed6
Autor:
Lahari Uppuluri, Christina Huan Shi, Dharma Varapula, Eleanor Young, Rachel L. Ehrlich, Yilin Wang, Danielle Piazza, Joshua Chang Mell, Kevin Y. Yip, Ming Xiao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract In this report, we present OLAF-Seq, a novel strategy to construct a long-read sequencing library such that adjacent fragments are linked with end-terminal duplications. We use the CRISPR-Cas9 nickase enzyme and a pool of multiple sgRNAs to
Externí odkaz:
https://doaj.org/article/9486052d66e34db0a67a24216131f04b
Autor:
Kelly Yichen Li, Claudia Ha Ting Tam, Hongbo Liu, Samantha Day, Cadmon King Poo Lim, Wing Yee So, Chuiguo Huang, Guozhi Jiang, Mai Shi, Heung Man Lee, TRANSCEND Consortium, Hui-yao Lan, Cheuk-Chun Szeto, Robert L. Hanson, Robert G. Nelson, Katalin Susztak, Juliana C. N. Chan, Kevin Y. Yip, Ronald C. W. Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation marker
Externí odkaz:
https://doaj.org/article/6fafc569b3d44fc4acef9a1d7bbfdf99
Autor:
Jacob Schreiber, Carles Boix, Jin wook Lee, Hongyang Li, Yuanfang Guan, Chun-Chieh Chang, Jen-Chien Chang, Alex Hawkins-Hooker, Bernhard Schölkopf, Gabriele Schweikert, Mateo Rojas Carulla, Arif Canakoglu, Francesco Guzzo, Luca Nanni, Marco Masseroli, Mark James Carman, Pietro Pinoli, Chenyang Hong, Kevin Y. Yip, Jeffrey P. Spence, Sanjit Singh Batra, Yun S. Song, Shaun Mahony, Zheng Zhang, Wuwei Tan, Yang Shen, Yuanfei Sun, Minyi Shi, Jessika Adrian, Richard Sandstrom, Nina Farrell, Jessica Halow, Kristen Lee, Lixia Jiang, Xinqiong Yang, Charles Epstein, J. Seth Strattan, Bradley Bernstein, Michael Snyder, Manolis Kellis, William Stafford, Anshul Kundaje, ENCODE Imputation Challenge Participants
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to impute the remainder. However, identifying the best imputation methods and what measu
Externí odkaz:
https://doaj.org/article/af322f5b401248609628ec2ad86cadd9
Autor:
Yanbing Wang, Timothy Shin Heng Mak, Saloni Dattani, Maria-Merce Garcia-Barcelo, Alexander Xi Fu, Kevin Y. Yip, Elly Sau-Wai Ngan, Paul Kwang-Hang Tam, Clara Sze-Man Tang, Pak Chung Sham
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations. However, the allelic effects so far identifie
Externí odkaz:
https://doaj.org/article/e0f03ea6c3674b9dae007715d6d2abea
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background After an infection, human cells may contain viral genomes in the form of episomes or integrated DNA. Comparing the genomic sequences of different strains of a virus in human cells can often provide useful insights into its behavio
Externí odkaz:
https://doaj.org/article/7c7b69967c834452b236e898acf83584
Autor:
Ke-En Tan, Wei Lun Ng, Georgi K. Marinov, Ken Hung-On Yu, Lu Ping Tan, Ee Shan Liau, Sook Yan Goh, Kok Siong Yeo, Kevin Y. Yip, Kwok-Wai Lo, Alan Soo-Beng Khoo, Lee-Fah Yap, Chee-Kwee Ea, Yat-Yuen Lim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Epstein-Barr virus (EBV) has been recently found to generate novel circular RNAs (circRNAs) through backsplicing. However, comprehensive catalogs of EBV circRNAs in other cell lines and their functional characterization are still lacking. In
Externí odkaz:
https://doaj.org/article/6f280b89ec074aafa9b102c63d7b3441
Autor:
Jeff P. Bruce, Ka-Fai To, Vivian W. Y. Lui, Grace T. Y. Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y. Yip, Brigette B. Y. Ma, John K. S. Woo, Edwin P. Hui, Michael K. F. Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y. Y. Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie Prokopec, Man Wu, Johnny S. H. Kwan, Yuchen Liu, Jason Y. K. Chan, C. Andrew van Hasselt, Lawrence S. Young, Christopher W. Dawson, Ian C. Paterson, Lee-Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T. C. Chan, Trevor J. Pugh, Kwok-Wai Lo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activ
Externí odkaz:
https://doaj.org/article/84b65b92c11446b886dec64811b68199
Autor:
Wenyan Nong, Zhe Qu, Yiqian Li, Tom Barton-Owen, Annette Y. P. Wong, Ho Yin Yip, Hoi Ting Lee, Satya Narayana, Tobias Baril, Thomas Swale, Jianquan Cao, Ting Fung Chan, Hoi Shan Kwan, Sai Ming Ngai, Gianni Panagiotou, Pei-Yuan Qian, Jian-Wen Qiu, Kevin Y. Yip, Noraznawati Ismail, Siddhartha Pati, Akbar John, Stephen S. Tobe, William G. Bendena, Siu Gin Cheung, Alexander Hayward, Jerome H. L. Hui
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Wenyan Nong, Zhe Qu, Yiqian Li, Tom Barton-Owen, Annette Wong and colleagues provide genomes and small RNA transcriptomes for the mangrove horseshoe crab and the tri-spine horseshoe crab. They show that horseshoe crabs have undergone three rounds of
Externí odkaz:
https://doaj.org/article/fa619e949d124eb7ba5f90e70e4ad43b
Autor:
Wenyan Nong, Jianquan Cao, Yiqian Li, Zhe Qu, Jin Sun, Thomas Swale, Ho Yin Yip, Pei Yuan Qian, Jian-Wen Qiu, Hoi Shan Kwan, William Bendena, Stephen Tobe, Ting Fung Chan, Kevin Y. Yip, Ka Hou Chu, Sai Ming Ngai, Karl Yk Tsim, Peter W. H. Holland, Jerome H. L. Hui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Jellyfish plays an important ecological role in surface waters and the deep sea. Here the authors report genome sequences of two true jellyfish, Sanderia malayensis and Rhopilema esculentum, showing distinct homeobox gene clusters and sesquiterpenoid
Externí odkaz:
https://doaj.org/article/75e4802ab7e94f13954f8bca870da522