Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kevin Y. Sanbonmatsu"'
Publikováno v:
Trends in Biochemical Sciences. 34:390-400
The molecular mechanisms by which tRNA molecules enter and transit the ribosome during mRNA translation remains elusive. However, recent genetic, biochemical and structural studies offer important new findings into the ordered sequence of events unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a2881b43700fdcc8c5b1d7389ddc23
https://doi.org/10.1016/j.tibs.2009.04.004
https://doi.org/10.1016/j.tibs.2009.04.004
Autor:
Kevin Y. Sanbonmatsu, Andrea C. Vaiana
Publikováno v:
Journal of Molecular Biology. 386:648-661
Gentamicin is a potent antibiotic used in combination therapy for inhalation Anthrax disease. The drug is also often used in therapy for Methicillin-Resistant Staphylococcus Aureus (MRSA). Gentamicin works by flipping a conformational switch on the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a02328adb40bae5b61a599e6de16e6
https://doi.org/10.1016/j.jmb.2008.12.035
https://doi.org/10.1016/j.jmb.2008.12.035
Autor:
Chang-Shung Tung, Kevin Y. Sanbonmatsu
Publikováno v:
Biophysical Journal. 87(4):2714-2722
The ribosome is a large molecular complex that consists of at least three ribonucleic acid molecules and a large number of proteins. It translates genetic information from messenger ribonucleic acid and makes protein accordingly. To better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c43d16cb804b55079b14a1bc58a286a
Autor:
Kevin Y. Sanbonmatsu, Simpson Joseph
Publikováno v:
Journal of Molecular Biology. 328:33-47
The ribosome must discriminate between correct and incorrect tRNAs with sufficient speed and accuracy to sustain an adequate rate of cell growth. Here, we report the results of explicit solvent molecular dynamics simulations, which address the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7139ccb0d392a04f81ddb1c92851eb01
https://doi.org/10.1016/s0022-2836(03)00236-5
https://doi.org/10.1016/s0022-2836(03)00236-5
Autor:
John J. Portman, Hugh Nymeyer, Angel E. Garcia, Kevin Y. Sanbonmatsu, Sandrasegaram Gnanakaran
Publikováno v:
Current Opinion in Structural Biology. 13:168-174
Developments in the design of small peptides that mimic proteins in complexity, recent advances in nanosecond time-resolved spectroscopy methods to study peptides and the development of modern, highly parallel simulation algorithms have come together
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb21bf9ad086f511d489aa2a0dc75bd4
https://doi.org/10.1016/s0959-440x(03)00040-x
https://doi.org/10.1016/s0959-440x(03)00040-x
Publikováno v:
Nature Structural Biology. 9:750-755
Understanding the structural basis of ribosomal function requires close comparison between biochemical and structural data. Although a large amount of biochemical data are available for the Escherichia coli ribosome, the structure has not been solved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd0ef67df76beed69a40a4d4e634d9d
https://doi.org/10.1038/nsb841
https://doi.org/10.1038/nsb841
Autor:
Kevin Y. Sanbonmatsu, Angel E. Garcia
Publikováno v:
Proteins: Structure, Function, and Genetics. 42:345-354
We studied the energy landscape of the peptide Ace-GEWTYDDATKTFTVTE-Nme, taken from the C-terminal fragment (41-56) of protein G, in explicit aqueous solution by a highly parallel replica-exchange approach that combines molecular dynamics trajectorie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::047a8163ba2d5770efe8b6885c394d52
https://doi.org/10.1002/1097-0134(20010215)42:3<345::aid-prot50>3.0.co
https://doi.org/10.1002/1097-0134(20010215)42:3<345::aid-prot50>3.0.co
Autor:
John Saunders, Paul C. Whitford, Alexander Schug, Kevin Y. Sanbonmatsu, José N. Onuchic, Scott P. Hennelly
Publikováno v:
Biophysical Journal. 96:L7-L9
Riboswitches are noncoding RNAs that regulate gene expression in response to changing concentrations of specific metabolites. Switching activity is affected by the interplay between the aptamer domain and expression platform of the riboswitch. The ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f1575c72de6d5c80773ac36fa2b54d
https://doi.org/10.1016/j.bpj.2008.10.033
https://doi.org/10.1016/j.bpj.2008.10.033
The ribosome is a ribonucleoprotein complex that is central to gene expression in every organism. Considered a molecular machine, the ribosome has the responsibility of implementing the genetic code by converting information residing in the messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cfc92838c32b38e6cc76e0b805bdaa1
https://doi.org/10.1016/b978-0-12-374920-8.00907-3
https://doi.org/10.1016/b978-0-12-374920-8.00907-3
Autor:
Daniel S. Terry, Scott C. Blanchard, James B. Munro, José N. Onuchic, Christian M. T. Spahn, Peter Geggier, Roger B. Altman, Paul C. Whitford, Kevin Y. Sanbonmatsu
Publikováno v:
Ribosomes ISBN: 9783709102145
Single-molecule fluorescence resonance energy transfer (smFRET) (reviewed in Munro et al., 2009) and cryo-electron microscopy (cryo-EM) investigations (Frank and Spahn, 2006; Spahn and Penczek, 2009; Fischer et al., 2010) of the translation apparatus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b168e2cb1cf9727aa2cb9f057cba26c
https://doi.org/10.1007/978-3-7091-0215-2_24
https://doi.org/10.1007/978-3-7091-0215-2_24