Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kevin Y Chen"'
Autor:
Ryan M Jamiolkowski, Kevin Y Chen, Shane A Fiorenza, Alyssa M Tate, Shawn H Pfeil, Yale E Goldman
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222964 (2019)
In single molecule fluorescence studies, background emission from labeled substrates often restricts their concentrations to non-physiological nanomolar values. One approach to address this challenge is the use of zero-mode waveguides (ZMWs), nanosca
Externí odkaz:
https://doaj.org/article/e4b24f5c9dfe46599509e528b681fcf6
Autor:
Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated
Externí odkaz:
https://doaj.org/article/e163cebf0d034cc0b49fca7e959be290
Autor:
Seth Ahlquist, Kevin Y. Chen, Brendan Y. Shi, Brandon Romero, John G. Horneff, Alexandra I. Stavrakis, Christos Photopoulos
Publikováno v:
Seminars in Arthroplasty: JSES. 33:174-179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73333086ce02fd00db468c72d5ffac4e
https://doi.org/10.1053/j.sart.2022.10.001
https://doi.org/10.1053/j.sart.2022.10.001
Autor:
Ishani Joshi, Monica Peravali, Xue Geng, Suman Rao, Kevin Y. Chen, Irina Veytsman, Giuseppe Giaccone, Stephen V. Liu, Chul Kim
Publikováno v:
Clinical Lung Cancer. 23:438-445
While the introduction of immune checkpoint inhibitors (ICI) such as pembrolizumab has significantly improved survival for patients with metastatic non-small cell lung cancer (NSCLC), there remains a need for improved predictive and prognostic biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb98d689bcd9ec36ace900a7adddcb6
https://doi.org/10.1016/j.cllc.2022.03.010
https://doi.org/10.1016/j.cllc.2022.03.010
Autor:
Megan L. Insco, Brian J. Abraham, Sara J. Dubbury, Ines H. Kaltheuner, Sofia Dust, Constance Wu, Kevin Y. Chen, David Liu, Stanislav Bellaousov, Anna M. Cox, Benjamin J. E. Martin, Tongwu Zhang, Calvin G. Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E. Esgdaille, Telmo Henriques, Kevin M. Brown, Stephen J. Chanock, Matthias Geyer, Karen Adelman, Phillip A. Sharp, Richard A. Young, Paul L. Boutz, Leonard I. Zon
Publikováno v:
Science
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 ( CDK13 ) is mutated in melanoma, and patient-mutated CDK13 accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0b2b1bcb20159e50e884d8f56a8dd
https://doi.org/10.1126/science.abn7625
https://doi.org/10.1126/science.abn7625
Autor:
David E. Fisher, Bradley E. Bernstein, Leonard I. Zon, Julia Newton-Bishop, Jian Jin, Yan Xiong, Brian B. Liau, C. Thomas Powell, Whitney Silkworth, Yang Feng, Yao Zhan, Lajos V. Kemeny, Ellen van Rooijen, Jennifer A. Lo, Nhu Nguyen, Yotam Drier, Joey Mark S. Diaz, Joanna Pozniak, Sathya Muralidhar, Kevin Y. Chen, Megan L. Insco, Qing Yu Weng, Shinichiro Kato
Pathways associated with G9a copy number in the Leeds melanoma cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde627f65467cad50b99ae6553a5c48a
https://doi.org/10.1158/2159-8290.22535413.v1
https://doi.org/10.1158/2159-8290.22535413.v1
Autor:
Christina Chan, S. Patrick Walton, Sean Foster, Jason Portis, R. Chauncey Splichal, Irene Li, Kevin Y. Chen, Amrita Oak, Aritro Nath
S1A. Plasmids containing single guide RNAs targeted against the IRE1 locus. B. XBP1 splicing assay to assay IRE1 endoribonuclease activity in Hep3B and MDA MB 231 cells. S2. CRISPR clones obtained for MDA-MB-231 cells. S3. CRISPR clones obtained for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19498f9ceb3993ec0912331b00ea9548
https://doi.org/10.1158/1541-7786.22514098
https://doi.org/10.1158/1541-7786.22514098
Autor:
David E. Fisher, Bradley E. Bernstein, Leonard I. Zon, Julia Newton-Bishop, Jian Jin, Yan Xiong, Brian B. Liau, C. Thomas Powell, Whitney Silkworth, Yang Feng, Yao Zhan, Lajos V. Kemeny, Ellen van Rooijen, Jennifer A. Lo, Nhu Nguyen, Yotam Drier, Joey Mark S. Diaz, Joanna Pozniak, Sathya Muralidhar, Kevin Y. Chen, Megan L. Insco, Qing Yu Weng, Shinichiro Kato
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a348e4563481b651158ecb74bd36dd
https://doi.org/10.1158/2159-8290.c.6547855.v1
https://doi.org/10.1158/2159-8290.c.6547855.v1
Autor:
Robert Hubal, Laura Bobbitt, Sarah Garfinkle, Suzanne C. Harris, Brandon D. Powell, Madison S. Oxley, Heidi N. Anksorus, Kevin Y. Chen
Publikováno v:
Pharmacy, Vol 8, Iss 4, p 209 (2020)
Concept maps are graphical representations of how various concepts relate to one another. Assessment of concept maps developed by students in the pharmacy curriculum helps to evaluate student understanding of course material. However, providing feedb
Externí odkaz:
https://doaj.org/article/63fa4cba8bf44edd9dfda31ef49be530
Autor:
Kevin Y. Chen, Kelly M. Brunk, Bianka A. Patel, Kurtis J. Stocker, Jessica J. Auten, Kaitlyn M. Buhlinger, Benyam Muluneh
Publikováno v:
Pharmacy, Vol 8, Iss 2, p 52 (2020)
Chronic lymphocytic leukemia (CLL) is a hematologic malignancy that has seen significant advances in care over the last 5 years with the approval of oral agents such as ibrutinib and venetoclax for the treatment of this disease. As such, there has be
Externí odkaz:
https://doaj.org/article/eabfd58173114fe5b5f4b8bafebbc0bb