Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kevin X. Le"'
Autor:
Helen Crehan, Bin Liu, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Kevin X. Le, Barbara J. Caldarone, Jeffrey L. Frost, Thore Hettmann, Birgit Hutter-Paier, Brian O’Nuallain, Mi-Ae Park, Marcelo F. DiCarli, Inge Lues, Stephan Schilling, Cynthia A. Lemere
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive
Externí odkaz:
https://doaj.org/article/a0a62adb0fd742e6bf4a5334e028d25a
Autor:
Stephan Schilling, Brian O'Nuallain, Marcelo F. DiCarli, Mi-Ae Park, Helen Crehan, Kevin X. Le, Bin Liu, Birgit Hutter-Paier, Martin Kleinschmidt, Thore Hettmann, Cynthia A. Lemere, Jens Ulrich Rahfeld, Barbara J. Caldarone, Jeffrey L. Frost, Inge Lues
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging
Autor:
Daniel L.A. van den Hove, Bart P. F. Rutten, Roberta M. Palmour, Monique Havermans, Roy Lardenoije, Kevin X. Le, Anne van Casteren, Cynthia A. Lemere
Publikováno v:
Molecular and Cellular Neuroscience, 86, 1-15. Elsevier Science
Molecular and Cellular Neuroscience
Molecular and Cellular Neuroscience
Both aging and Alzheimer's disease (AD) are associated with widespread epigenetic changes, with most evidence suggesting global hypomethylation in AD. It is, however, unclear how these age-related epigenetic changes are linked to molecular aberration
Autor:
Lee A. Trojanczyk, M. Kerry O'Banion, Qiaoqiao Shi, Paul A. Jones, Shuyan Wang, Bin Liu, Marcelo F. Di Carli, Robert G. Hinshaw, Paul Lorello, Jacqueline P. Williams, Jeffrey L. Frost, Vladimir Reiser, Kevin X. Le, Mi-Ae Park, William Trigg, Anthony P. Belanger, Cynthia A. Lemere, Shipra Dubey, Barbara J. Caldarone, Peter Holton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate the short-term effects of space radiation, we irradiated 4-month-old Alzheimer’s d
Autor:
Shuyan Wang, Mi-Ae Park, Peter Holton, Bin Liu, Paul A. Jones, William Trigg, Jeffrey L. Frost, Shipra Dubey, Marcelo F. Di Carli, Kevin X. Le, Vladimir Reiser, Cynthia A. Lemere, Anthony P. Belanger
Publikováno v:
The Journal of Neuroscience. 35:15716-15730
Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator protein (TSPO), a marker for activated microglia, have been used as positron emi
Autor:
Katherine Merry, Jean-Cosme Dodart, Cynthia A. Lemere, Sarah B. Matousek, Jessica E. Kenison, Jeffrey L. Frost, Kenneth J. Colodner, Qiaoqiao Shi, Shaomin Li, Soyon Hong, Kevin X. Le, Beth Stevens, Barbara J. Caldarone
Publikováno v:
The Journal of Neuroscience. 35:13029-13042
The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via microglia-mediated pruning of inappropriate synapses during brain develo
Autor:
Barbara J. Caldarone, Qiaoqiao Shi, Cynthia A. Lemere, Bin Liu, Richard T. Watson, Kevin X. Le, Supurna Ghosh, Angela Sze Man Hung
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
Rong Ma, Beth Stevens, Saba Chowdhury, Kevin X. Le, Barbara J. Caldarone, Cynthia A. Lemere, Soyon Hong, Qiaoqiao Shi
Publikováno v:
Science translational medicine. 9(392)
The complement cascade is an innate immune response to remove pathogens in the peripheral immune system but also plays an important role in microglia-mediated synaptic refinement during brain development. Complement C3 is elevated in Alzheimer’s di
Autor:
Stephan Schilling, Jeffrey L. Frost, Barbara J. Caldarone, Cynthia A. Lemere, Inge Lues, Jens-Ulrich Rahfeld, Martin Kleinschmidt, Brian O'Nuallain, Kevin X. Le, Hans-Ulrich Demuth, Bin Liu
Pyroglutamate-3 amyloid-beta (pGlu-3 Aβ) is an N-terminally truncated Aβ isoform likely playing a decisive role in Alzheimer's disease pathogenesis. Here, we describe a prophylactic passive immunization study in APPswe/PS1ΔE9 mice using a novel pG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb88e04fc94f7759ba6259b32dcfb6b3
https://europepmc.org/articles/PMC4641825/
https://europepmc.org/articles/PMC4641825/
Autor:
Brian O'Nuallain, Stephan Schilling, Jens-Ulrich Rahfeld, Marcelo F. DiCarli, Jeffrey L. Frost, Emmett Fitzpatrick, Kevin X. Le, William Trigg, Barbara J. Caldarone, Vladimir Reiser, Mi-Ae Park, Martin Kleinschmidt, Bin Liu, Inge Lues, Cynthia A. Lemere, Helen Crehan
Publikováno v:
Neurobiology of Aging. 39:S12-S13
Pyroglutamate-3 Av (pGlu-3 Av) is a highly pathogenic Av species in Alzheimer's disease (AD) brain. The Av N-terminus is truncated and the 3rd residue (glu) cyclized by glutaminyl cyclase, leading to increased aggregation and neurotoxicity. Previousl