Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kevin Woollard"'
Autor:
Marc Jonathan George, MB ChB, PhD, Nur Hayati Jasmin, BSc, MRes, Valerie Taylor Cummings, Angela Richard-Loendt, BSc, MSc, Francesca Launchbury, BSc, Kevin Woollard, PhD, Tabitha Turner-Stokes, MB BChir, Ana Isabel Garcia Diaz, BSc, Mark Lythgoe, PhD, Daniel James Stuckey, BSc, DPhil, Aroon Dinesh Hingorani, MB BS, PhD, Derek William Gilroy, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 6, Iss 5, Pp 431-443 (2021)
Summary: Interleukin (IL)-6 is an emerging therapeutic target in myocardial infarction (MI). IL-6 has 2 distinct signaling pathways: trans-signaling, which mediates inflammation, and classic signaling, which also has anti-inflammatory effects. The no
Externí odkaz:
https://doaj.org/article/e06def29764245ddb2c7cbd27d1feb2b
Autor:
Matthew K. Siggins, Nicola N. Lynskey, Lucy E. Lamb, Louise A. Johnson, Kristin K. Huse, Max Pearson, Suneale Banerji, Claire E. Turner, Kevin Woollard, David G. Jackson, Shiranee Sriskandan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloo
Externí odkaz:
https://doaj.org/article/82442a72732d4568ad2c06ae269341a8
Autor:
Adela Constantinescu-Bercu, Luigi Grassi, Mattia Frontini, Isabelle I Salles-Crawley, Kevin Woollard, James TB Crawley
Publikováno v:
eLife, Vol 9 (2020)
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand factor/glycoprotein Ibα-dependent
Externí odkaz:
https://doaj.org/article/968a474c4c384d029e4443e500a51ab0
Autor:
Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 4, Pp 463-471 (2016)
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively. Novel transgenic (Tg) strains add research opportu
Externí odkaz:
https://doaj.org/article/53ef4e3c3e914ca18869da9a878f9f19
Autor:
Evans Asowata, Simone Romoli, Jennifer Tan, Scott Hoffmann, Margaret Huang, Fynn Krause, Benjamin Jenkins, Daniel Jachimowicz, Rasmus Agren, Barbara Musial, Krishna Mahbubani, Michael Murphy, Julian Griffin, Albert Koulman, Pernille Hansen, Stephanie Ling, Kourosh Saeb-Parsy, Kevin Woollard
The limited availability of human kidney biopsies to study acute kidney injury (AKI) has restricted the development of effective therapies for this condition. Here, we validate the use of deceased transplant organ donor kidneys to study human AKI and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ae5d2cb6ee47a8a4366ddc164c2f97
https://doi.org/10.21203/rs.3.rs-1461691/v1
https://doi.org/10.21203/rs.3.rs-1461691/v1
Autor:
Kevin Woollard, Aditya Srivatsan
Despite extensive characterization of the role of platelet activation and the coagulation cascade in acute ischemic stroke (AIS), few studies have analyzed the immune cell composition of AIS thrombi. Recent articles describing a function of neutrophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27f98dc49c18b1ceab00f397bc9e4d9
http://hdl.handle.net/10044/1/82819
http://hdl.handle.net/10044/1/82819
Publikováno v:
Advances in experimental medicine and biology. 1003
In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a26dfeb31b72486c93bde388bbe63e5e
https://pubmed.ncbi.nlm.nih.gov/28667557
https://pubmed.ncbi.nlm.nih.gov/28667557
Autor:
Mohammed Shamim Rahman, Kevin Woollard
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319576114
In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111a5d5e6af22cffe7162b35a9d9d9a
http://hdl.handle.net/10044/1/74526
http://hdl.handle.net/10044/1/74526
Autor:
Gareth Hyde, Kevin Woollard, Ramzi Khamis, Michael M. Johns, Joseph J. Boyle, Dorian O. Haskard, Shang-Hung Chang
Publikováno v:
Circulation. 130
Introduction/Objective: Although IgG autoantibodies reacting with modified LDL have been associated with cardiovascular events, there is controversy as to whether such antibodies can be pathogenic. We set out to generate monoclonal autoantibodies rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e42f609600fb85b6f6e5d09c8375fc02
https://doi.org/10.1161/circ.130.suppl_2.13773
https://doi.org/10.1161/circ.130.suppl_2.13773
Publikováno v:
ISDN Explained: Worldwide Network and Applications Technology, Third Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccc74bf5e8bd47bc99e90885d68c48c
https://doi.org/10.1002/0470841796.ch5
https://doi.org/10.1002/0470841796.ch5