Perturbation of the mitochondrial import machinery by aggregation prone Tau affects organelle morphology and reduces neuronal complexity

Autor: Kevin Wilkinson, Hope Isobel Needs, Jeremy Henley, Ian Collinson

Protein import into mitochondria is an intricate and highly conserved process essential for organellar biogenesis, and maintenance of its structure and function. Defects in the import apparatus impact the assembly of the respiratory chain and ATP syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eee6acd1eb605abab1be93cc39160845
https://doi.org/10.1101/2022.11.30.518502

Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1

Autor: Kevin Wilkinson, Chun Guo

Publikováno v: Autophagy
Wilkinson, K A & Guo, C 2022, ' Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1 ', Autophagy, vol. 18, no. 7, pp. 1743-1745 . https://doi.org/10.1080/15548627.2022.2046898

The selective clearance of mitochondria by mitophagy is an important quality control mechanism for maintaining mitochondrial and cellular health. Iron chelation, for example by the compound deferiprone (DFP), leads to a specific form of PINK1-PRKN/Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7a6b7f13888b8a6bec58dd73d7233d
https://europepmc.org/articles/PMC9298444/

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

Autor: Kevin Wilkinson, Jithin Nair, Jeremy Henley

Publikováno v: STAR Protoc
STAR Protocols, Vol 2, Iss 4, Pp 100992-(2021)
Nair, J D, Henley, J M & Wilkinson, K A 2021, ' Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation ', STAR Protocols, vol. 2, no. 4, 100992 . https://doi.org/10.1016/j.xpro.2021.100992

Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107ffccc564a69668c7c725c14f026a
https://doi.org/10.1016/j.xpro.2021.100992

Bioactive Coating From White Portland Cement Deposited by Pulsed Laser Deposition

Autor: Geoffrey Ndungu, Kevin Wilkinson, Svitlana Fialkova, Sergey Yarmolenko, Jagannathan Sankar

Publikováno v: Volume 14: Emerging Technologies; Materials: Genetics to Structures; Safety Engineering and Risk Analysis.

Objective. We report the study of feasibility to produce the thing bioactive coating from experimental dental cement using pulsed laser deposition (PLD) technique. Methods. The targets for PLD system (disks 30 mm in diameter × 5 mm thick) were sinte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc061c9579d6922ec64ec5e99bc90a52
https://doi.org/10.1115/imece2017-70986

Functional stoichiometry of soil microbial communities after amendment with stabilised organic matter

Autor: Kevin Wilkinson, Antonio F. Patti, Michael T. Rose, Timothy R. Cavagnaro, Ee Ling Ng, Cassandra R. Schefe

Publikováno v: Soil Biology and Biochemistry. 76:170-178

The transformation of organic matter amendments in the soil is regulated by soil microbial communities. We examined the utility of ecological and functional stoichiometry theories to explain microbial transformation of organic amendments in the soil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9b7330768c6e866fff2d7cda2e753b9
https://doi.org/10.1016/j.soilbio.2014.05.016