Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin Whited"'
Autor:
Nanami Senoo, Dinesh K. Chinthapalli, Matthew G. Baile, Vinaya K. Golla, Bodhisattwa Saha, Oluwaseun B. Ogunbona, James A. Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Dror Chorev, Nathan N. Alder, Eric R. May, Carol V. Robinson, Steven M. Claypool
Publikováno v:
bioRxiv
SummaryThe mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocator, ANT in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62db7af3c461236f7d1ff1a4f2f4668b
https://europepmc.org/articles/PMC10187269/
https://europepmc.org/articles/PMC10187269/
Autor:
Nathan N. Alder, Xianlin Han, J. Michael McCaffery, Erin N. Pryce, Murugappan Sathappa, Ya-Wen Lu, Kevin Whited, Matthew G. Baile, Steven M. Claypool
Publikováno v:
Journal of Biological Chemistry. 289:1768-1778
After biosynthesis, an evolutionarily conserved acyl chain remodeling process generates a final highly homogeneous and yet tissue-specific molecular form of the mitochondrial lipid cardiolipin. Hence, cardiolipin molecules in different organisms, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de91a7c65e0cfa5de4452d048ae0fcf
https://doi.org/10.1074/jbc.m113.525733
https://doi.org/10.1074/jbc.m113.525733
Publikováno v:
Molecular Biology of the Cell
Our understanding of the clinically relevant tafazzin-mediated cardiolipin (CL) remodeling pathway is incomplete. In this study, a new trafficking step required for CL remodeling has been identified. Further, it is demonstrated that flux through this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6054eb59ae7add32851b82e200c79262
https://doi.org/10.1091/mbc.e13-03-0121
https://doi.org/10.1091/mbc.e13-03-0121
Publikováno v:
The Journal of cell biology, vol 192, iss 3
The Journal of Cell Biology
The Journal of Cell Biology
Complexes containing tafazzin, which remodels newly synthesized cardiolipin, are destabilized by mutations associated with Barth syndrome.
Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTH
Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c109f2e38b6c56173da1e8bdc9429d0a
https://doi.org/10.1083/jcb.201008177
https://doi.org/10.1083/jcb.201008177
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81025f049618b6b0b919f52603715f9
https://doi.org/10.1096/fasebj.27.1_supplement.585.14
https://doi.org/10.1096/fasebj.27.1_supplement.585.14
Publikováno v:
Human molecular genetics. 22(3)
Patients with Barth syndrome (BTHS), a rare X-linked disease, suffer from skeletal and cardiomyopathy and bouts of cyclic neutropenia. The causative gene encodes tafazzin, a transacylase, which is the major determinant of the final acyl chain composi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a6bccf3f7d7cb919074bbc73b4bbd7
https://pubmed.ncbi.nlm.nih.gov/23100323
https://pubmed.ncbi.nlm.nih.gov/23100323