Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kevin W. Waddell"'
Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts
Autor:
Kevin W. Waddell, Fan Shi, Eduard Y. Chekmenev, Roman V. Shchepin, Kirsten A. Groome, Greg Zimay, Milton L. Truong, Quinn A. Best, Aaron M. Coffey, Boyd M. Goodson, Ping He
Publikováno v:
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Two synthetic strategies are investigated for the preparation of water-soluble iridium-based catalysts for NMR signal amplification by reversible exchange (SABRE). In one approach, PEGylation of a variant N-heterocyclic carbene provided a novel catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c0e0eb40ef8e5523f449ba622b1c36
https://doi.org/10.1021/acs.jpcc.6b04484
https://doi.org/10.1021/acs.jpcc.6b04484
Autor:
Eduard Y. Chekmenev, Thomas Theis, Milton L. Truong, Warren S. Warren, Fan Shi, Roman V. Shchepin, Kevin W. Waddell, Aaron M. Coffey, Boyd M. Goodson
Publikováno v:
The Journal of Physical Chemistry Letters
We report NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization of the rare isotopes in "neat" liquids, each composed only of an otherwise pure target compound with isotopic natural abundance (n.a.) and millimolar concentrations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374ae552b698202d164296dadf78d05b
https://doi.org/10.1021/acs.jpclett.5b00782
https://doi.org/10.1021/acs.jpclett.5b00782
Autor:
Aaron M. Coffey, Fan Shi, Eduard Y. Chekmenev, Warren S. Warren, Kevin W. Waddell, Milton L. Truong, Thomas Theis, Roman V. Shchepin, Boyd M. Goodson
Publikováno v:
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization technique that enables nuclear spin polarization enhancement of molecules via concurrent chemical exchange of a target substrate and parahydrogen (the source of spin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182b1bbbf2aff634bbf02e2457b05709
https://doi.org/10.1021/acs.jpcc.5b01799
https://doi.org/10.1021/acs.jpcc.5b01799
Publikováno v:
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Two types of nanoscale catalysts were created to explore NMR signal enhancement via reversible exchange (SABRE) at the interface between heterogeneous and homogeneous conditions. Nanoparticle and polymer comb variants were synthesized by covalently t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8069d120025ab29c8390d8b7e35fa8
http://europepmc.org/articles/PMC4501382
http://europepmc.org/articles/PMC4501382
Autor:
Eduard Y. Chekmenev, Fan Shi, Thomas Theis, Kevin W. Waddell, Milton L. Truong, Warren S. Warren, Aaron M. Coffey, Roman V. Shchepin, Boyd M. Goodson
Publikováno v:
Journal of the American Chemical Society
Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda151a37d221d413032f647dac2a323
http://europepmc.org/articles/PMC4333583
http://europepmc.org/articles/PMC4333583
Autor:
Kevin W. Waddell, Eduard Y. Chekmenev, Roman V. Shchepin, Kirill V. Kovtunov, Milton L. Truong, Danila A. Barskiy, Boyd M. Goodson, Kirsten A. Groome, Aaron M. Coffey, Ping He, Fan Shi, Quinn A. Best, Igor V. Koptyug
Publikováno v:
ChemPhysChem. 15:4100-4107
By using 5.75 and 47.5 mT nuclear magnetic resonance (NMR) spectroscopy, up to 10(5)-fold sensitivity enhancement through signal amplification by reversible exchange (SABRE) was enabled, and subsecond temporal resolution was used to monitor an exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8d8483c1f578e061a6aa4efd04057
https://doi.org/10.1002/cphc.201402607
https://doi.org/10.1002/cphc.201402607
Autor:
Danila A. Barskiy, Igor V. Koptyug, Kevin W. Waddell, Eduard Y. Chekmenev, Boyd M. Goodson, Fan Shi, Kirsten A. Groome, Ping He, Quinn A. Best, Kirill V. Kovtunov, Roman V. Shchepin, Aaron M. Coffey
Publikováno v:
Analytical Chemistry
We demonstrate the feasibility of microscale molecular imaging using hyperpolarized proton and carbon-13 MRI contrast media and low-field (47.5 mT) preclinical scale (38 mm i.d.) 2D magnetic resonance imaging (MRI). Hyperpolarized proton images with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56968390979cf3585f0363fae24a3f36
https://doi.org/10.1021/ac501638p
https://doi.org/10.1021/ac501638p
Heteronuclear refocusing by nonlinear phase and amplitude modulation on a single transmitter channel
Publikováno v:
Journal of Magnetic Resonance. 245:58-62
The application of low magnetic fields to heteronuclear NMR has expanded recently alongside the emergence of methods for achieving near unity polarization of spin ensembles, independent of magnetic field strength. The parahydrogen induced hyperpolari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e4fc9fb4082c7fa3872d266286ef8b
https://doi.org/10.1016/j.jmr.2014.05.010
https://doi.org/10.1016/j.jmr.2014.05.010
Autor:
Danila A. Barskiy, Kevin W. Waddell, Igor V. Koptyug, Eduard Y. Chekmenev, Aaron M. Coffey, Roman V. Shchepin, Kirill V. Kovtunov
Publikováno v:
Analytical Chemistry
Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly polarized, catalyst-free fluids can be obtained in a catalysis-free regime using a chemical reaction with molecular addition of parahydrogen to a water-soluble R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d46e5d445c79b1e8c200c1cdf2bb399
http://europepmc.org/articles/PMC4079322
http://europepmc.org/articles/PMC4079322
Publikováno v:
Contrast Media & Molecular Imaging. 9:333-341
Indirect proton detection of 13C hyperpolarized contrast agents potentially enables greater sensitivity. Presented here is a study of sub-second projection imaging of hyperpolarized 13C contrast agent addressing the obstacle posed by water suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a9e1609d76a037df60049728d3171a
https://doi.org/10.1002/cmmi.1579
https://doi.org/10.1002/cmmi.1579