Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kevin W. Ng"'
Autor:
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S.S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterize most cancer types and are linked with disease outcomes. However, the underlying processes are incompletely understood. Here, we show that elevated transcr
Externí odkaz:
https://doaj.org/article/394a3762490547b7bf44934409acfbbe
Autor:
Katey S. S. Enfield, Erin A. Marshall, Christine Anderson, Kevin W. Ng, Sara Rahmati, Zhaolin Xu, Megan Fuller, Katy Milne, Daniel Lu, Rocky Shi, David A. Rowbotham, Daiana D. Becker-Santos, Fraser D. Johnson, John C. English, Calum E. MacAulay, Stephen Lam, William W. Lockwood, Raj Chari, Aly Karsan, Igor Jurisica, Wan L. Lam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histolo
Externí odkaz:
https://doaj.org/article/97564470fd144a769823f07282f004b8
Autor:
Feng Xu, Naoya Tanabe, Dragos M. Vasilescu, John E. McDonough, Harvey O. Coxson, Kohei Ikezoe, Daisuke Kinose, Kevin W. Ng, Stijn E. Verleden, Wim A. Wuyts, Bart M. Vanaudenaerde, Johny Verschakelen, Joel D. Cooper, Marc E. Lenburg, Katrina B. Morshead, Alexander R. Abbas, Joseph R. Arron, Avrum Spira, Tillie-Louise Hackett, Thomas V. Colby, Christopher J. Ryerson, Raymond T. Ng, James C. Hogg
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103325- (2021)
Background: The transition from normal lung anatomy to minimal and established fibrosis is an important feature of the pathology of idiopathic pulmonary fibrosis (IPF). The purpose of this report is to examine the molecular and cellular mechanisms as
Externí odkaz:
https://doaj.org/article/26f5a885d9724d8aa67297d80c625a69
Autor:
Brenda C. Minatel, Victor D. Martinez, Kevin W. Ng, Adam P. Sage, Tomas Tokar, Erin A. Marshall, Christine Anderson, Katey S. S. Enfield, Greg L. Stewart, Patricia P. Reis, Igor Jurisica, Wan L. Lam
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-6 (2018)
Abstract MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules that are conserved across several t
Externí odkaz:
https://doaj.org/article/17bf2ab7578d49079a071c1e19f013b2
Autor:
Erin A. Marshall, Kevin W. Ng, Christine Anderson, Roland Hubaux, Kelsie L. Thu, Wan L. Lam, Victor D. Martinez
Publikováno v:
Genomics Data, Vol 6, Iss C, Pp 145-148 (2015)
Lung cancer is the leading cause of cancer death worldwide, and has a five-year survival rate of 18% [1]. MARK2 is a serine/threonine-protein kinase, and is a key component in the phosphorylation of microtubule-associated proteins [2,3]. A recent stu
Externí odkaz:
https://doaj.org/article/46a72dce51e74ba2ae645a39b1d808ab
Autor:
Jesse Boumelha, Sophie de Carné Trécesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel I. Vogel, Alejandro Suárez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Publikováno v:
Cancer Res
Mutations in oncogenes such as KRAS and EGFR cause a high proportion of lung cancers. Drugs targeting these proteins cause tumor regression but ultimately fail to elicit cures. As a result, there is an intense interest in how to best combine targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128d1ca05f75d8769b0a636c3c99db68
https://doi.org/10.1158/0008-5472.can-22-0325
https://doi.org/10.1158/0008-5472.can-22-0325
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Data from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fc3e20f035a7d1519858bb7c34e1ae
https://doi.org/10.1158/0008-5472.22432362
https://doi.org/10.1158/0008-5472.22432362
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Table from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5646e5b6edd1bf21906dd5a24045f7ea
https://doi.org/10.1158/0008-5472.22432356.v1
https://doi.org/10.1158/0008-5472.22432356.v1
Publikováno v:
Advances in immunology. 155
Most antibody produced by humans originates from mucosal B cell responses. The rules, mechanisms, and outcomes of this process are distinct from B cell responses to infection. Within the context of the intestine, we discuss the induction of follicula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a525a2a65b03d331db46c62d6ebdcfa
https://pubmed.ncbi.nlm.nih.gov/36357013
https://pubmed.ncbi.nlm.nih.gov/36357013
Autor:
Dhira Joshi, Lucy R. Marshall, Lucy R. Wedderburn, Stavroula Paraskevopoulou, Steve Gamblin, Georgina H. Cornish, Sonia Gandhi, Charles Swanton, John W. McCauley, William Bolland, Svend Kjaer, Nikhil Faulkner, Hannah Rickman, Rachel Ulferts, Philip Hobson, D.J. Benton, Laura E. McCoy, Ana Agua-Doce, Rupert Beale, Annachiara Rosa, Chloe Roustan, Nicola O’Reilly, Catherine F Houlihan, Christopher Earl, Eleni Nastouli, A.G. Wrobel, Rachael Thompson, Brigitta Stockinger, Kirsty Thomson, Catherine Moore, Bethany R. Jebson, Anna Radziszewska, Coziana Ciurtin, Andrew Riddell, Saira Hussain, Emilie Sanchez, Peter Cherepanov, Elizabeth C. Rosser, Meredyth G. Ll Wilkinson, Kevin W. Ng, Ruth Harvey, Philip A. Walker, Hannah Peckham, Judith Heaney, Gee Yen Shin, Moira J. Spyer, George Kassiotis
Publikováno v:
Science (New York, N.y.)
Science
Science
Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b78b2fb2e3b3317126ad45bbfb9684
https://doi.org/10.1126/science.abe1107
https://doi.org/10.1126/science.abe1107