Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kevin W. Kuntz"'
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 25K, Table S1: LCC Values for EPZ-6438 for WSU-DLCL2 Human Lymphoma Cells Dosed Either Continuously or After Compound Washout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12304f9a85f43c2b5fe15a51c85b039b
https://doi.org/10.1158/1535-7163.22499892
https://doi.org/10.1158/1535-7163.22499892
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations are hypothesized to confer an oncogenic dependency on EZH2 enzymatic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ced2f5eb38e4c70192dc2fd63ef50
https://doi.org/10.1158/1535-7163.c.6536301
https://doi.org/10.1158/1535-7163.c.6536301
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, Tim J Wigle, Dipti Sadalge, Kevin W Kuntz, Margaret Porter Scott, William P Janzen, Richard Chesworth, Kenneth W Duncan, Darren M Harvey, John W Lampe, Lorna H Mitchell, Robert A Copeland
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197082 (2018)
WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemi
Externí odkaz:
https://doaj.org/article/5a738d78cc0446bf85ca79bb119bc45d
Autor:
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse J Smith, Kevin W Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170539 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0158888.].
Externí odkaz:
https://doaj.org/article/794b53db2605483789c901bbe947d23f
Autor:
Jennifer R. Molina, Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko kunii, Kristy G. Kuplast-Barr, Bin Gui, Sunaina P. Nayak, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Alvin Z. Lu, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Ellen Bamberg, Mario Niepel, Jan-Rung Mo, William D. Church, Ahmed S. Mady, Jeff Song, Zacharenia A. Varsamis, Luke Utley, Patricia E. Rao, Timoty J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Kristen McEachern, Heike Keilhack
Publikováno v:
Cancer Research. 82:2154-2154
Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138b6edb388c9ff28b5c6026a9134c0a
https://doi.org/10.1158/1538-7445.am2022-2154
https://doi.org/10.1158/1538-7445.am2022-2154
Autor:
Sarah K Knutson, Natalie M Warholic, L Danielle Johnston, Christine R Klaus, Tim J Wigle, Dorothy Iwanowicz, Bruce A Littlefield, Margaret Porter-Scott, Jesse J Smith, Mikel P Moyer, Robert A Copeland, Roy M Pollock, Kevin W Kuntz, Alejandra Raimondi, Heike Keilhack
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e111840 (2014)
Patients with non-Hodgkin lymphoma (NHL) are treated today with a cocktail of drugs referred to as CHOP (Cyclophosphamide, Hydroxyldaunorubicin, Oncovin, and Prednisone). Subsets of patients with NHL of germinal center origin bear oncogenic mutations
Externí odkaz:
https://doaj.org/article/4dd56e327a7d4f3e9e537bcf0baa99bb
Autor:
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse J Smith, Kevin W Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170539 (2017)
PLoS ONE, Vol 12, Iss 1, p e0170539 (2017)
The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to regulating the conformational state of chromatin and the resultant transcriptional output. The enzymes that catalyze these activities are often contained withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a522ca88d5ee079ae682e9409517a586
https://doi.org/10.1371/journal.pone.0170539
https://doi.org/10.1371/journal.pone.0170539