Výsledky vyhledávání - "Kevin W. Harris"

Data from Toll-Like Receptor 9 Mediates CpG Oligonucleotide–Induced Cellular Invasion

Autor: Katri S. Selander, Kevin W. Harris, Katri S. Vuopala, Arja Jukkola-Vuorinen, Eeva Rahko, Sonja Brooks, David Graves, Savita Wakchoure, Li Li, Melinda A. Merrell, Joanna M. Ilvesaro

Toll-like receptor 9 (TLR9) belongs to the innate immune system and recognizes microbial and vertebrate DNA. We showed previously that treatment with the TLR9-agonistic ODN M362 (a CpG sequence containing oligonucleotide) induces matrix metalloprotei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae934a7bac138c87ef3979caed3daa8
https://doi.org/10.1158/1541-7786.c.6541396.v1

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Akademický článek

Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans.

Autor: Madison R Chandler, Kimberly S Keene, Johanna M Tuomela, Andres Forero-Torres, Renee Desmond, Katri S Vuopala, Kevin W Harris, Nancy D Merner, Katri S Selander

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0183832 (2017)

Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. Low tumor TLR9 expression has been associated with poor survival in Caucasian patients with triple negative breast cancer (TNBC).

Externí odkaz: https://doaj.org/article/82fcacfe1fee4d6e887f5591379aac40

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Toll-like receptor 9 expression is associated with breast cancer sensitivity to the growth inhibitory effects of bisphosphonates in vitro and in vivo

Autor: Kevin W. Harris, Jeremy Clark, Jouko Sandholm, Aleksi Schrey, Arja Jukkola-Vuorinen, Jaakko Lehtimäki, Pirkko Härkönen, Katri S. Selander, Johanna Tuomela, Sadanandan E. Velu, Tamiko Ishizu

Publikováno v: Oncotarget

// Jouko Sandholm 1 , Jaakko Lehtimaki 2 , Tamiko Ishizu 2, 3 , Sadanandan E. Velu 4 , Jeremy Clark 4 , Pirkko Harkonen 2 , Arja Jukkola-Vuorinen 5 , Aleksi Schrey 6 , Kevin W. Harris 7, 8, 9 , Johanna M. Tuomela 2 , Katri S. Selander 4, 10 1 Cell Im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bb071587aaa492569f53f630360fd1
http://europepmc.org/articles/PMC5349995

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DNA from dead cancer cells induces TLR9-mediated invasion and inflammation in living cancer cells

Autor: Dongquan Chen, Katri S. Selander, Joanna M. Ilvesaro, Johanna Tuomela, Jouko Sandholm, David E. Graves, Mika Kaakinen, Ankita Patel, Kevin W. Harris, Joonas H. Kauppila

Publikováno v: Breast Cancer Research and Treatment. 142:477-487

TLR9 is a cellular DNA-receptor, which is widely expressed in breast and other cancers. Although synthetic TLR9-ligands induce cancer cell invasion in vitro, the role of TLR9 in cancer pathophysiology has remained unclear. We show here that living ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3392eb799426b325e77e0550b3f05ab6
https://doi.org/10.1007/s10549-013-2762-0

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Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer

Autor: Petri Lehenkari, Kevin W. Harris, Katri S. Selander, Johanna Tuomela, Jouko Sandholm, Joonas H. Kauppila

Publikováno v: Oncology Letters

Toll-like receptor-9 (TLR9) is an intracellular DNA receptor that is widely expressed in breast and other cancers. We previously demonstrated that low tumor TLR9 expression upon diagnosis is associated with significantly shortened disease-specific su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a6a63ff1cfd113e1dfc257760a64a4
https://doi.org/10.3892/ol.2013.1602

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Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer

Autor: Kevin W. Harris, Christine S. Pressey, Peeter Karihtala, David E. Graves, Katri S. Vuopala, Dongquan Chen, Johanna Tuomela, Katri S. Selander, Päivi Auvinen, Jouko Sandholm, Ylermi Soini, Joonas H. Kauppila, Joanna M. Ilvesaro, Pirkko Härkönen, Saila Kauppila, Arja Jukkola-Vuorinen

Publikováno v: Breast Cancer Research and Treatment. 135:481-493

Toll-like receptor-9 (TLR9) is a DNA receptor widely expressed in cancers. Although synthetic TLR9 ligands induce cancer cell invasion in vitro, the role of TLR9 in cancer pathophysiology is unclear. We discovered that low tumor TLR9 expression is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef03b2ff4e9f60edb99b9aa7c2fcff94
https://doi.org/10.1007/s10549-012-2181-7

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Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia

Autor: Christopher A. Klug, Hyung-Gyoon Kim, Kevin W. Harris, Heidi J. Nick, Vishnu Reddy, Chia-Wei Chang

Publikováno v: Blood. 119:1522-1531

The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO+ patient samples, differing classes of activating c-KIT receptor tyrosine kinase mutations have been observed. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b030d947afb7bd8526399d55d5ca120
https://doi.org/10.1182/blood-2011-02-338228

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P2-11-10: Low Toll-Like Receptor 9 Expression Is Required for the Aggressive Behavior of Triple Negative Breast Cancer Cells in Hypoxia

Autor: Christine S. Pressey, P Karihtala, Kevin W. Harris, Jouko Sandholm, S Kauppila, Katri S. Selander, A Jukkola-Vuorinen, Katri S. Vuopala, Johanna Tuomela, David E. Graves, Joonas H. Kauppila, Joanna M. Ilvesaro

Publikováno v: Cancer Research. 71:P2-11

Toll-like receptor-9 (TLR9) is a cellular DNA-receptor and a member of the innate immune system which is widely expressed in breast cancers. Although synthetic TLR9-ligands stimulate breast cancer cell invasion in vitro, through down-regulation of ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::891183d42b01cbf881c791b85af40790
https://doi.org/10.1158/0008-5472.sabcs11-p2-11-10

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Estrogen receptor-α and sex steroid hormones regulate Toll-like receptor-9 expression and invasive function in human breast cancer cells

Autor: Martin R. Johnson, Joonas H. Kauppila, Jouko Sandholm, Katri S. Selander, Johanna Tuomela, Christine S. Pressey, Kevin W. Harris, Arja Jukkola-Vuorinen, Markku H. Vaarala

Publikováno v: Breast Cancer Research and Treatment. 132:411-419

Toll-like receptor 9 (TLR9) is a cellular DNA-receptor, which is widely expressed in cancer. Synthetic TLR9-ligands induce cancer cell invasion in vitro, but the role of TLR9 in cancer pathophysiology remains unclear. Increased TLR9 expression has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed90254734be598790cdb238cd08aec
https://doi.org/10.1007/s10549-011-1590-3

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