Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevin W. Currin"'
Autor:
Gautam K. Pandey, Swarooparani Vadlamudi, Kevin W. Currin, Anne H. Moxley, Jayna C. Nicholas, Jessica C. McAfee, K. Alaine Broadaway, Karen L. Mohlke
Publikováno v:
HGG Advances, Vol 5, Iss 2, Pp 100275- (2024)
Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for liver disease and lipid-related metabolic traits, although identifying their target genes and molecular mechanisms remains challenging. We predicted target gen
Externí odkaz:
https://doaj.org/article/8b7139b6dc3b4818bc6f4371df2c9d29
Autor:
Hannah J. Perrin, Kevin W. Currin, Swarooparani Vadlamudi, Gautam K. Pandey, Kenneth K. Ng, Martin Wabitsch, Markku Laakso, Michael I. Love, Karen L. Mohlke
Publikováno v:
PLoS Genetics, Vol 17, Iss 10 (2021)
Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity acro
Externí odkaz:
https://doaj.org/article/18b6484704474b5f9bc3936b6a808459
Autor:
Maren E. Cannon, Kevin W. Currin, Kristin L. Young, Hannah J. Perrin, Swarooparani Vadlamudi, Alexias Safi, Lingyun Song, Ying Wu, Martin Wabitsch, Markku Laakso, Gregory E. Crawford, Karen L. Mohlke
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2521-2533 (2019)
Identifying the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose tissue has been restricted due to limited characterization of adipose transcriptional regulatory elements. We profiled chromatin accessibility in thr
Externí odkaz:
https://doaj.org/article/d39a2a63168c4093a2fabb1ed9107c8f
Autor:
Sarah M. Brotman, Chelsea K. Raulerson, Swarooparani Vadlamudi, Kevin W. Currin, Qiujin Shen, Victoria A. Parsons, Apoorva K. Iyengar, Tamara S. Roman, Terrence S. Furey, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Markku Laakso, Päivi Pajukanta, Karen L. Mohlke
Publikováno v:
Am J Hum Genet
Alternate splicing events can create isoforms that alter gene function, and genetic variants associated with alternate gene isoforms may reveal molecular mechanisms of disease. We used subcutaneous adipose tissue of 426 Finnish men from the METSIM st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ce8c29bc59f9c6489918d443c0aadd
https://europepmc.org/articles/PMC8764203/
https://europepmc.org/articles/PMC8764203/
Autor:
K. Alaine Broadaway, Gautam Kumar Pandey, Swarooparani Vadlamudi, Kevin W Currin, Karen L. Mohlke
Publikováno v:
Diabetes. 70
Genome-wide association studies (GWAS) have identified many loci that affect liver- and lipid-related metabolic traits, but the causal variants, target genes and mechanisms for most loci have not been characterized. GWAS loci are often enriched in ti
Autor:
Aldons J. Lusis, Karen L. Mohlke, Maren E Cannon, Mete Civelek, Michael Boehnke, Laura J. Scott, Chelsea K. Raulerson, Terrence S. Furey, Heather M. Stringham, Cassandra N. Spracklen, Anne U. Jackson, Francis S. Collins, Arthur Ko, Danyu Lin, Adam E. Locke, Michael I. Love, Päivi Pajukanta, Ying Wu, Christian Fuchsberger, John C. Kidd, Johanna Kuusisto, Markku Laakso, Kevin W Currin, Narisu Narisu, Sarah M Brotman, Ryan P. Welch
Publikováno v:
The American Journal of Human Genetics. 105:773-787
Genome-wide association studies (GWASs) have identified thousands of genetic loci associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat distribution, and adiposity, although most causal genes remain unknown. W
Autor:
Ying Wu, Karen L. Mohlke, Swarooparani Vadlamudi, Gregory E. Crawford, Alexias Safi, Markku Laakso, Kevin W Currin, Lingyun Song, Hannah J Perrin, Kristin L. Young, Martin Wabitsch, Maren E Cannon
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2521-2533 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Identifying the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose tissue has been restricted due to limited characterization of adipose transcriptional regulatory elements. We profiled chromatin accessibility in thr
Autor:
Sirintorn Stantripop, Sean Black, Ricardo D’Oliveira Albanus, S. L. Ho, John P. Didion, Beatrice B. Barnabas, Francis S. Collins, Brian P. Schmidt, Peter Orchard, Quino Maduro, Casandra Montemayor, Christina Sison, Karen L. Mohlke, Hannah J Perrin, K. Alaine Broadaway, Alice C. Young, Juyun Kim, Morgan Park, Laura J. Scott, Swarooparani Vadlamudi, Erin G. Schuetz, Karen Schandler, Narisu Narisu, James W. Thomas, Richelle Legaspi, Shelise Brooks, Gerard G. Bouffard, Joel Han, Federico Innocenti, Nancy Riebow, Vivek Rai, Lyudmila Dekhtyar, James C. Mullikin, Stephen C. J. Parker, Michael R. Erdos, Holly Coleman, Tingfen Yan, Catherine A. Masiello, Lori L. Bonnycastle, Jacqueline R. Idol, Amarjit S. Chaudhry, Jennifer C. McDowell, Kevin W Currin, Meghana Vemulapalli, Pamela J. Thomas, Amy S. Etheridge
Publikováno v:
Am J Hum Genet
Identifying the molecular mechanisms by which genome-wide association study (GWAS) loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) help identify GWAS loci that may alter GWAS traits by modulating ch
Autor:
Sarah M Brotman, Chelsea K. Raulerson, Laura J. Scott, Francis S. Collins, Maren E Cannon, James P. Davis, Hannah J Perrin, Christian Fuchsberger, Karen L. Mohlke, Päivi Pajukanta, Cassandra N. Spracklen, Narisu Narisu, Johanna Kuusisto, Ying Wu, Apoorva K Iyengar, Ryan P. Welch, Kevin W Currin, Markku Laakso, Aaron T Crain, Heather M. Stringham, Yun Li, Adam E. Locke, Anne U. Jackson, Michael Boehnke, Swarooparani Vadlamudi
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 9, p e1009019 (2020)
PLoS Genetics, Vol 16, Iss 9, p e1009019 (2020)
Loci identified in genome-wide association studies (GWAS) can include multiple distinct association signals. We sought to identify the molecular basis of multiple association signals for adiponectin, a hormone involved in glucose regulation secreted
Autor:
Praveen Sethupathy, Christopher A. Haiman, Jeannette T. Bensen, Kathryn L. Lunetta, Chi Chen Hong, Qianqian Zhu, Andrew F. Olshan, Mariaelisa Graff, Edward A. Ruiz-Narváez, Song Yao, Christine B. Ambrosone, Joel S. Parker, Chad V. Pecot, Lara E. Sucheston-Campbell, Melissa A. Troester, Kevin W Currin, Stephen A. Haddad, Lynn Rosenberg, Kristin L. Young, Song Liu, Elisa V. Bandera, Julie R. Palmer
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Background MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and breast cancer (BC). We sought to