Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kevin W Freeman"'
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116998 (2015)
Neuroblastomas (NBL) and Ewing's sarcomas (EWS) together cause 18% of all pediatric cancer deaths. Though there is growing interest in targeting the dysregulated metabolism of cancer as a therapeutic strategy, this approach has not been fully examine
Externí odkaz:
https://doaj.org/article/92a191977c3341d8a901357ae07c429d
Autor:
Alexander E Finlayson, Kevin W Freeman
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7833 (2009)
Invasion through the extracellular matrix (ECM) is important for wound healing, immunological responses and metastasis. We established an invasion-based cell motility screen using Boyden chambers overlaid with Matrigel to select for pro-invasive gene
Externí odkaz:
https://doaj.org/article/fccd5e915a6c4c6594895dc46faae72e
Autor:
Basia Galinski, Marcus Luxemburg, Yosef Landesman, Bruce Pawel, Katherine J. Johnson, Stephen R. Master, Kevin W. Freeman, David M. Loeb, Jean M. Hébert, Daniel A. Weiser
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101114- (2021)
Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an FDA-approved XPO1 inhibitor. Similar data are emerging in childhood ca
Externí odkaz:
https://doaj.org/article/df22e3a1000a4cbeba345adf608973b1
Autor:
Philip M. Potter, Anang A. Shelat, Stephen W. White, R. Kiplin Guy, Daniel Savic, Taosheng Chen, Martine F. Roussel, Marie Morfouace, Richard E. Lee, Jun Yang, Vincent A. Boyd, Nagakumar Bharatham, Brandon M. Young, Jeanine E. Price, Jonathan A. Low, Kevin W. Freeman, Rachelle R. Olsen, William R. Shadrick, Zhenmei Li, Geoffrey Neale, Sourav Das, M. Brett Waddell, Michele Connelly, Sergio C. Chai, Barbara Jonchere, Nancy E. Martinez, Lyudmila Tsurkan, Mi-Kyung Yun, Liying Chi, P. Jake Slavish
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5d71e4e32bd0d5208d4d9130ecd2d2
https://doi.org/10.1158/0008-5472.c.6511882.v1
https://doi.org/10.1158/0008-5472.c.6511882.v1
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 181-191 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Retinoic acids (RAs) are the most successful therapeutics for cancer differentiation therapy used in high-risk neuroblastoma (NB) maintenance therapy but are limited in effectiveness. This study identifies a strategy for improving efficacy through di
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
Autor:
Barbara Jonchere, Jonathan Low, Michele Connelly, Liying Chi, Sergio C. Chai, R. Kiplin Guy, Kevin W. Freeman, Brandon Young, Jeanine E. Price, Mi-Kyung Yun, Marie Morfouace, Anang A. Shelat, Geoffrey Neale, Rachelle R. Olsen, Nagakumar Bharatham, Daniel Savic, Stephen W. White, P. Jake Slavish, Vincent A. Boyd, Lyudmila Tsurkan, Jun J. Yang, Nancy E. Martinez, Zhenmei Li, Martine F. Roussel, Philip M. Potter, M. Brett Waddell, William R. Shadrick, Richard E. Lee, Taosheng Chen, Sourav Das
Publikováno v:
Cancer Res
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acety
Autor:
Kevin W. Freeman, Jerold E. Rehg, Joel H. Otero, David B. Finkelstein, Zhirong Yin, Kirby Wallace, Rachelle R. Olsen, Yong Dong Wang, Jesus Garcia-Lopez
Publikováno v:
Oncogene
Neuroblastoma (NBL) is an embryonal cancer of the sympathetic nervous system (SNS), which causes 15% of pediatric cancer deaths. High-risk NBL is characterized by N-Myc amplification and segmental chromosomal gains and losses. Owing to limited diseas
Autor:
Kevin W. Freeman
Publikováno v:
Success in Academic Surgery: Basic Science ISBN: 9783030146436
This chapter will broadly cover the newest genome editing technology, clustered regularly interspaced short palindromic repeats (CRISPR), and CRISPR-associated system (Cas), as a critical tool for a modern research laboratory. Multiplex gene mutagene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e66eabbf808696346ec3265bccb8ebd
https://doi.org/10.1007/978-3-030-14644-3_11
https://doi.org/10.1007/978-3-030-14644-3_11
Autor:
Kevin W. Freeman, Chelsea DeVaux, Kirby Wallace, Ashton King, Jesus Garcia-Lopez, Rachelle R. Olsen, Joel H. Otero, Andrew M. Davidoff
Publikováno v:
Cancer Research. 80:B30-B30
Large segmental chromosomal alterations are common to cancer and a feature of high-risk neuroblastoma (NBL). Though they are early or initiating events in cancer, including often being found in precancerous lesions, their contribution to tumorigenesi
Autor:
David Finkelstein, Kevin W. Freeman, Brian Gudenas, Rachelle R. Olsen, Jesus Garcia-Lopez, Paul A. Northcott, Andrew M. Davidoff, Joel H. Otero, Kirby Wallace, Yong-Dong Wang, Jerold E. Rehg
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 454-464.e5 (2020)
Summary: Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL. Although distal 1p36 losses associate with s