Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kevin W, Joseph"'
Autor:
Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010726 (2022)
Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for und
Externí odkaz:
https://doaj.org/article/e4d901c328ff4314aeae578f4ca25641
Autor:
Leah D. Brandt, Shuang Guo, Kevin W. Joseph, Jana L. Jacobs, Asma Naqvi, John M. Coffin, Mary F. Kearney, Elias K. Halvas, Xiaolin Wu, Stephen H. Hughes, John W. Mellors
Publikováno v:
Viruses, Vol 13, Iss 7, p 1235 (2021)
Efforts to cure HIV-1 infection require better quantification of the HIV-1 reservoir, particularly the clones of cells harboring replication-competent (intact) proviruses, termed repliclones. The digital droplet PCR assays commonly used to quantify i
Externí odkaz:
https://doaj.org/article/c8828ff3d5bf4e7b9f52b36e9c8dc885
Autor:
Kevin W. Joseph, Elias K. Halvas, Leah D. Brandt, Sean C. Patro, Jason W. Rausch, Abha Chopra, Simon Mallal, Mary F. Kearney, John M. Coffin, John W. Mellors
Publikováno v:
Journal of virology. 96(13)
The integration of human immunodeficiency virus type 1 (HIV-1) into chromosomal DNA establishes the long-term persistence of HIV-1 as proviruses despite effective antiretroviral therapy (ART). Characterizing proviruses is difficult because of their r
Autor:
Joshua C. Cyktor, Jason W. Rausch, Wei Shao, Camille Tumiotto, Elias K. Halvas, Michael J. Bale, John W. Mellors, Mary F. Kearney, John M. Coffin, Michele D. Sobolewski, John K. Bui, Jana L. Jacobs, Shuang Guo, Leah D. Brandt, Kevin W. Joseph, Brandon F. Keele, Stephen H. Hughes, Xiaolin Wu, Gene D. Morse
Publikováno v:
J Clin Invest
BACKGROUNDHIV-1 viremia that is not suppressed by combination antiretroviral therapy (ART) is generally attributed to incomplete medication adherence and/or drug resistance. We evaluated individuals referred by clinicians for nonsuppressible viremia
Autor:
John M. Coffin, Rebecca Hoh, Jason W. Rausch, Brandon F. Keele, Frank Maldarelli, Sean C Patro, Christine M. Fennessey, Shuang Guo, Christopher Hautman, Leah D. Brandt, Brian T. Luke, Elias K. Halvas, Steven G. Deeks, Kevin W. Joseph, Wei Shao, Michael J. Bale, Adam A. Capoferri, Aurelie Niyongabo, Michele D. Sobolewski, Jonathan Spindler, Xiaolin Wu, Jeffrey M. Milush, Stephen H. Hughes, Ben Murrell, John W. Mellors, Castle Raley, Mary F. Kearney, Jenna M Hasson, Wei-Shau Hu, Ann Wiegand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 51
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populati
Autor:
Leah D. Brandt, Elias K. Halvas, Xiaolin Wu, Shuang Guo, Dimiter Demirov, Ling Su, John W. Mellors, Beth Scott, Aaron T. Hamilton, Kevin W. Joseph, Baktiar Karim, Asma Naqvi, Zhonghe Sun, Donna Butcher, Stephen H. Hughes, Marintha Heil
Publikováno v:
Science Advances. 7
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk of cancer, most of the risk is associated with immunodeficiency and coinfection by oncogenic virus (Epstein-Barr virus, Kaposi sarc
Autor:
John W, Mellors, Shuang, Guo, Asma, Naqvi, Leah D, Brandt, Ling, Su, Zhonghe, Sun, Kevin W, Joseph, Dimiter, Demirov, Elias K, Halvas, Donna, Butcher, Beth, Scott, Aaron, Hamilton, Marintha, Heil, Baktiar, Karim, Xiaolin, Wu, Stephen H, Hughes
Publikováno v:
Science Advances
Description
HIV-1 proviruses in the first introns of STAT3 and LCK can contribute to the development of T cell lymphomas.
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk
HIV-1 proviruses in the first introns of STAT3 and LCK can contribute to the development of T cell lymphomas.
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk
Autor:
Michael J. Bale, Mary Grace Katusiime, Elias K. Halvas, Bronwyn Kirby-McCullough, Mark F. Cotton, Gert U. van Zyl, Mary F. Kearney, John W. Mellors, Wei-Shau Hu, Imogen A. Wright, Wei Shao, Susan Engelbrecht, Kevin W. Joseph
Publikováno v:
J Virol
In adults starting antiretroviral therapy (ART) during acute infection, 2% of proviruses that persist on ART are genetically intact by sequence analysis. In contrast, a recent report in children treated early failed to detect sequence-intact provirus
Autor:
Xiaolin Wu, John M. Coffin, Stephen H. Hughes, Elias K. Halvas, John W. Mellors, Asma Naqvi, Shuang Guo, Kevin W. Joseph, Jana L. Jacobs, Leah D. Brandt, Mary F. Kearney
Publikováno v:
Viruses
Volume 13
Issue 7
Viruses, Vol 13, Iss 1235, p 1235 (2021)
Volume 13
Issue 7
Viruses, Vol 13, Iss 1235, p 1235 (2021)
Efforts to cure HIV-1 infection require better quantification of the HIV-1 reservoir, particularly the clones of cells harboring replication-competent (intact) proviruses, termed repliclones. The digital droplet PCR assays commonly used to quantify i
Autor:
Wei Shao, Michael J. Bale, Bronwyn Kirby-McCullough, Elias K. Halvas, Mark F. Cotton, Mary Grace Katusiime, Imogen A. Wright, Susan Engelbrecht, Mary F. Kearney, Kevin W. Joseph, Wei Shau Hu, John W. Mellors, Gert U. van Zyl
Publikováno v:
SSRN Electronic Journal.
Background: In adults starting ART during acute infection, 2% of proviruses that persist on ART are intact (replication-competent) by sequence analysis. By contrast, a recent report in early treated children failed to detect sequence intact proviruse