Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kevin Van Bortle"'
Autor:
Kevin Van Bortle, David P. Marciano, Qing Liu, Tristan Chou, Andrew M. Lipchik, Sanjay Gollapudi, Benjamin S. Geller, Emma Monte, Rohinton T. Kamakaka, Michael P. Snyder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
RNA polymerase III changes its subunit composition during mammalian development. Here the authors report that loss of subunit POLR3G, which re-emerges in cancer, promotes expression of small NF90-associated RNA (snaR-A), a noncoding RNA implicated in
Externí odkaz:
https://doaj.org/article/d5d5e04e9f0d4ba195049ff05b893451
Autor:
Ruiying Cheng, Kevin Van Bortle
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
RNA polymerase III composition is shaped by the mutually exclusive incorporation of two paralogous subunits, RPC7α and RPC7β, encoded by genes POLR3G and POLR3GL in vertebrates. The expression of POLR3G and POLR3GL is spatiotemporally regulated dur
Externí odkaz:
https://doaj.org/article/936859179b1a4ff7a3c5b1b10e21fe84
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background The human genome is hierarchically organized into local and long-range structures that help shape cell-type-specific transcription patterns. Transfer RNA (tRNA) genes (tDNAs), which are transcribed by RNA polymerase III (RNAPIII)
Externí odkaz:
https://doaj.org/article/a0d62565df354eec80d90fab7141c26f
Autor:
Sihang Zhou, Kevin Van Bortle
Publikováno v:
WIREs RNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4354a86456b022305d640a5cd9b66c32
https://doi.org/10.1002/wrna.1782
https://doi.org/10.1002/wrna.1782
Autor:
Qing Liu, Haodi Wu, Zhana Duren, Chao Jiang, Kevin Van Bortle, Mingtao Zhao, Hongchao Guo, Chenchen Zhu, Qing-Jun Luo, Bingqing Zhao, Jun Liu, David Marciano, Joshua Gruber, Andrew Lipchik, Anil Narasimha, Nathaniel Watson, Ming-Shian Tsai, Takaaki Furihata, Lei Tian, Eric Wei, Yingxin Li, Lars Steinmetz, Wing H. Wong, Mark Kay, Joseph Wu, Michael Snyder
Tyrosine kinase inhibitors (TKIs) have been widely used for cancer chemotherapy, but they also cause cardiotoxicities in cancer patients. In this study, we used human stem cells as an in-vitro system to interrogate the mechanisms underlying drug-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09cc6a6fed2020a7b9d59cd90c40d5e
https://doi.org/10.21203/rs.3.rs-2343653/v1
https://doi.org/10.21203/rs.3.rs-2343653/v1
Autor:
Morteza Roodgar, Fabian P. Suchy, Lan H. Nguyen, Vivek K. Bajpai, Rahul Sinha, Jose G. Vilches-Moure, Kevin Van Bortle, Joydeep Bhadury, Ahmed Metwally, Lihua Jiang, Ruiqi Jian, Rosaria Chiang, Angelos Oikonomopoulos, Joseph C. Wu, Irving L. Weissman, Joseph L. Mankowski, Susan Holmes, Kyle M. Loh, Hiromitsu Nakauchi, Catherine A. VandeVoort, Michael P. Snyder
Publikováno v:
Cell Rep
Cell reports, vol 40, iss 9
Cell reports, vol 40, iss 9
As our closest living relatives, non-human primates uniquely enable explorations of human health, disease, development, and evolution. Considerable effort has thus been devoted to generating induced pluripotent stem cells (iPSCs) from multiple non-hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df8e0dd78de7dbde2c5c070f79d7bc
https://doi.org/10.1016/j.celrep.2022.111264
https://doi.org/10.1016/j.celrep.2022.111264
Autor:
Wing Hung Wong, Hongchao Guo, Chenchen Zhu, Ming-Shian Tsai, Takaaki Furihata, Nathaniel Watson, Chao Jiang, Lei Tian, Andrew M. Lipchik, Joshua J. Gruber, Michael Snyder, Kevin Van Bortle, Haodi Wu, David Marciano, Yingxin Li, Eric X Wei, Joseph C. Wu, Zhana Duren, Qing-Jun Luo, Brittany Lee-McMullen, Mark A. Kay, Bingqing Zhao, Lars M. Steinmetz, Ming-Tao Zhao, Anil Narasimha, Jun Liu, Qing Liu
SUMMARYMaternal drug exposure during pregnancy increases the risks of developmental cardiotoxicity, leading to congenital heart defects (CHDs). In this study, we used human stem cells as anin-vitrosystem to interrogate the mechanisms underlying drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8fa29c03d850439b80ce5ab0d56df6
Autor:
Kevin Van Bortle, Howard Y. Chang, Chao Jiang, Guangwen Wang, Jin Xu, Michael Snyder, Qing Liu, Joseph C. Wu, Ming-Tao Zhao, Xun Cheng
Publikováno v:
Circulation Research. 121:376-391
Rationale: Recent advances have improved our ability to generate cardiomyocytes from human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs). However, our understanding of the transcriptional regulatory networks underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b765a4c7c80697e1cb860aa5949fa7
https://doi.org/10.1161/circresaha.116.310456
https://doi.org/10.1161/circresaha.116.310456
Autor:
Michael Snyder, Michael I. Love, Muhammad S. Shamim, Douglas H. Phanstiel, Ido Machol, Kevin Van Bortle, Michael C. Bassik, Damek V. Spacek, Erez Lieberman Aiden, Gaelen T. Hess
SUMMARYThe three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab3ea26693a2acdfc9334c3a048c412
Autor:
Michael I. Love, Damek V. Spacek, Gaelen T. Hess, Douglas H. Phanstiel, Muhammad S. Shamim, Kevin Van Bortle, Erez Lieberman Aiden, Michael C. Bassik, Michael Snyder, Ido Machol
Publikováno v:
Molecular cell. 67(6)
The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6445a42eca9a48aa00276fa507d5eb1d
https://pubmed.ncbi.nlm.nih.gov/28890333
https://pubmed.ncbi.nlm.nih.gov/28890333