Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Kevin V, Shianna"'
Autor:
Kimberly Pelak, Anna C. Need, Jacques Fellay, Kevin V. Shianna, Sheng Feng, Thomas J. Urban, Dongliang Ge, Andrea De Luca, Javier Martinez-Picado, Steven M. Wolinsky, Jeremy J. Martinson, Beth D. Jamieson, Jay H. Bream, Maureen P. Martin, Persephone Borrow, Norman L. Letvin, Andrew J. McMichael, Barton F. Haynes, Amalio Telenti, Mary Carrington, David B. Goldstein, Galit Alter
Publikováno v:
PLoS Biology, Vol 9, Iss 12 (2011)
Externí odkaz:
https://doaj.org/article/217ee9a950054636b1c245ccb89b0265
Autor:
Kimberly Pelak, Anna C Need, Jacques Fellay, Kevin V Shianna, Sheng Feng, Thomas J Urban, Dongliang Ge, Andrea De Luca, Javier Martinez-Picado, Steven M Wolinsky, Jeremy J Martinson, Beth D Jamieson, Jay H Bream, Maureen P Martin, Persephone Borrow, Norman L Letvin, Andrew J McMichael, Barton F Haynes, Amalio Telenti, Mary Carrington, David B Goldstein, Galit Alter, NIAID Center for HIV/AIDS Vaccine Immunology
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001208 (2011)
A genome-wide screen for large structural variants showed that a copy number variant (CNV) in the region encoding killer cell immunoglobulin-like receptors (KIR) associates with HIV-1 control as measured by plasma viral load at set point in individua
Externí odkaz:
https://doaj.org/article/a88a6a17ab4c48cbaa44f406101588bf
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001033 (2010)
This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma
Externí odkaz:
https://doaj.org/article/4b6f6cf8876b4b6eae2787950499ed23
Autor:
Kimberly Pelak, Kevin V Shianna, Dongliang Ge, Jessica M Maia, Mingfu Zhu, Jason P Smith, Elizabeth T Cirulli, Jacques Fellay, Samuel P Dickson, Curtis E Gumbs, Erin L Heinzen, Anna C Need, Elizabeth K Ruzzo, Abanish Singh, C Ryan Campbell, Linda K Hong, Katharina A Lornsen, Alexander M McKenzie, Nara L M Sobreira, Julie E Hoover-Fong, Joshua D Milner, Ruth Ottman, Barton F Haynes, James J Goedert, David B Goldstein
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001111 (2010)
We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A
Externí odkaz:
https://doaj.org/article/11d35ff706624861ad364c3bc6c9cd73
Autor:
Nara L M Sobreira, Elizabeth T Cirulli, Dimitrios Avramopoulos, Elizabeth Wohler, Gretchen L Oswald, Eric L Stevens, Dongliang Ge, Kevin V Shianna, Jason P Smith, Jessica M Maia, Curtis E Gumbs, Jonathan Pevsner, George Thomas, David Valle, Julie E Hoover-Fong, David B Goldstein
Publikováno v:
PLoS Genetics, Vol 6, Iss 6, p e1000991 (2010)
Although more than 2,400 genes have been shown to contain variants that cause Mendelian disease, there are still several thousand such diseases yet to be molecularly defined. The ability of new whole-genome sequencing technologies to rapidly indentif
Externí odkaz:
https://doaj.org/article/f6de353cf3e240a6bc708768cf380973
Autor:
Margalida Rotger, Kristen K Dang, Jacques Fellay, Erin L Heinzen, Sheng Feng, Patrick Descombes, Kevin V Shianna, Dongliang Ge, Huldrych F Günthard, David B Goldstein, Amalio Telenti, Swiss HIV Cohort Study, Center for HIV/AIDS Vaccine Immunology
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000781 (2010)
There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, the contribution of variable
Externí odkaz:
https://doaj.org/article/70b9ed040f53413f865b468509610dbd
Autor:
Jacques Fellay, Dongliang Ge, Kevin V Shianna, Sara Colombo, Bruno Ledergerber, Elizabeth T Cirulli, Thomas J Urban, Kunlin Zhang, Curtis E Gumbs, Jason P Smith, Antonella Castagna, Alessandro Cozzi-Lepri, Andrea De Luca, Philippa Easterbrook, Huldrych F Günthard, Simon Mallal, Cristina Mussini, Judith Dalmau, Javier Martinez-Picado, José M Miro, Niels Obel, Steven M Wolinsky, Jeremy J Martinson, Roger Detels, Joseph B Margolick, Lisa P Jacobson, Patrick Descombes, Stylianos E Antonarakis, Jacques S Beckmann, Stephen J O'Brien, Norman L Letvin, Andrew J McMichael, Barton F Haynes, Mary Carrington, Sheng Feng, Amalio Telenti, David B Goldstein, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000791 (2009)
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3%
Externí odkaz:
https://doaj.org/article/e95ca120fa8643faa43ff375c73b9936
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000657 (2009)
The tumor suppressor p53 has been implicated in multiple functions that play key roles in health and disease, including ribosome biogenesis, control of aging, and cell cycle regulation. A genetic screen for negative regulators of innate immunity in C
Externí odkaz:
https://doaj.org/article/42d1bf627361417494bda2f53665a136
Autor:
Sreekumar G Pillai, Dongliang Ge, Guohua Zhu, Xiangyang Kong, Kevin V Shianna, Anna C Need, Sheng Feng, Craig P Hersh, Per Bakke, Amund Gulsvik, Andreas Ruppert, Karin C Lødrup Carlsen, Allen Roses, Wayne Anderson, Stephen I Rennard, David A Lomas, Edwin K Silverman, David B Goldstein, ICGN Investigators
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000421 (2009)
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of alpha(1)-antitrypsin, which is present in 1-2% of individuals with
Externí odkaz:
https://doaj.org/article/0fd390c869ee4b479764ed3a85e6df94
Autor:
Anna C. Need, Dongliang Ge, Michael E. Weale, Jessica Maia, Sheng Feng, Erin L. Heinzen, Kevin V. Shianna, Woohyun Yoon, Dalia Kasperavičiūtė, Massimo Gennarelli, Warren J. Strittmatter, Cristian Bonvicini, Giuseppe Rossi, Karu Jayathilake, Philip A. Cola, Joseph P. McEvoy, Richard S. E. Keefe, Elizabeth M. C. Fisher, Pamela L. St. Jean, Ina Giegling, Annette M. Hartmann, Hans-Jürgen Möller, Andreas Ruppert, Gillian Fraser, Caroline Crombie, Lefkos T. Middleton, David St. Clair, Allen D. Roses, Pierandrea Muglia, Clyde Francks, Dan Rujescu, Herbert Y. Meltzer, David B. Goldstein
Publikováno v:
PLoS Genetics, Vol 5, Iss 3 (2009)
Externí odkaz:
https://doaj.org/article/ee8f2989272a41b5b3a23afc4eef806e