Gabapentinoid Pharmacology in the Context of Emerging Misuse Liability

Autor: Alyssa M. Peckham, Kevin Tidgewell, Jordan R. Covvey, Kirk E. Evoy

Publikováno v: Journal of clinical pharmacologyReferences. 61

This article will review the epidemiology and pharmacology of gabapentinoids (gabapentin and pregabalin) relevant to their emerging misuse potential and provide guidance for clinical and regulatory management. Gabapentinoids are γ-aminobutyric acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e85abc18c51c2037eff9616bede6e1
https://pubmed.ncbi.nlm.nih.gov/34396549

Aqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced mono-arthritis: Evidence from in vivo and in vitro studies

Autor: Zacharie Sando, Judith Manialeu Pouadjeu, Basile Nganmegne Piegang, Télesphore Benoît Nguelefack, Kevin Tidgewell, Benedict J. Kolber, Douglas Alphonse Mouga Ngangoum, Pius Pum Tseuguem

Publikováno v: J Ethnopharmacol

ETHNOPHARMACOLOGICAL RELEVANCE: Paullinia pinnata L. (Sapindaceae) is an African woody vine, traditionally used for the treatment of itch and pain-related conditions such as rheumatoid arthritis. AIM: This work evaluates, in vitro and in vivo, the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefeec4bc085838b55418e2305ed36d5
https://pubmed.ncbi.nlm.nih.gov/30849505

Evaluating Marine Cyanobacteria as a Source for CNS Receptor Ligands

Autor: Stacy‐Ann J. Parker, Andrea L Rague, Kevin Tidgewell

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2665 (2018)

Natural products have a long history as a source of psychoactive agents and pharmacological tools for understanding the brain and its circuitry. In the last two decades, marine cyanobacteria have become a standard source of natural product ligands wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70283f9409996e8875aa7e9f419d06b
http://europepmc.org/articles/PMC6222545

Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands

Autor: Andrea L Rague, Kevin Tidgewell

Publikováno v: Mini reviews in medicinal chemistry. 18(7)

The serotonin system exerts its effects on the CNS and many peripheral systems. Of the 14 serotonin receptors, the 5-HT7 receptor is the most recently discovered. The 5-HT7 receptor has been shown to be involved in stress reduction, depression, and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91b1d9182f1e175aa096317d2502aea
https://pubmed.ncbi.nlm.nih.gov/28901854

Coibacins A–D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins

Autor: Laura M. Pineda, Niclas Engene, William H. Gerwick, Carmenza Spadafora, Lena Gerwick, Marcy J. Balunas, Manuel F. Grosso, Francisco A. Villa, Kevin Tidgewell, Dennis E. Kyle, Kerry L. McPhail

Publikováno v: Organic Letters. 14:3878-3881

Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl rin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95bb47c7080e80770fb51e1ec0623ef
https://doi.org/10.1021/ol301607q