Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kevin T. Halloran"'
Autor:
Jonathan S. Kingsbury, Cesar Calero-Rubio, Amendra Fernando, Yatin R. Gokarn, Pin-Kuang Lai, Theresa K. Cloutier, Kevin T. Halloran, Bernhardt L. Trout
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1583-1591
Protein aggregation can hinder the development, safety and efficacy of therapeutic antibody-based drugs. Developing a predictive model that evaluates aggregation behaviors during early stage development is therefore desirable. Machine learning is a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca77fb33dddf2da6c20e9967fcf3794
https://doi.org/10.1016/j.xphs.2020.12.014
https://doi.org/10.1016/j.xphs.2020.12.014
Autor:
Jifeng Zhang, Cesar Calero-Rubio, Walter Schwenger, Li Fu, Yatin R. Gokarn, Kevin T. Halloran, Jonathan S. Kingsbury, Michaela M. Lantz, Amandeep Saini, Christian Y. Airiau, Sarah Marie Auclair
Publikováno v:
Science Advances
Colloidal interactions in dilute solution singularly enable selection of well-behaved antibodies during drug discovery.
Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with
Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9b846fc70146e997caff56170d7fc7
https://pubmed.ncbi.nlm.nih.gov/32923611
https://pubmed.ncbi.nlm.nih.gov/32923611
Autor:
Yanming Wang, Srinivas Chakravarthy, Kevin T. Halloran, Osman Bilsel, Charles L. Brooks, Thomas C. Irving, C. Robert Matthews, Karunesh Arora
Triosephosphate isomerase (TIM) barrel proteins have not only a conserved architecture that supports a myriad of enzymatic functions, but also a conserved folding mechanism that involves on- and off-pathway intermediates. Although experiments have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef11069a2b93ec027b2fd2f8de3572e7
https://europepmc.org/articles/PMC6697809/
https://europepmc.org/articles/PMC6697809/
Virus capsid proteins reproducibly self-assemble into regularly-shaped, stable shells that protect the viral genome from external environmental assaults, while maintaining the high internal pressure of the tightly packaged viral genome. To elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6969f4d69d4be7a65a7f5cffe3f601
https://doi.org/10.1101/216911
https://doi.org/10.1101/216911
Publikováno v:
Chemistry - A European Journal. 19:15101-15104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9cfdc81011b856c7aeed5f3dafcf09
https://doi.org/10.1002/chem.201302354
https://doi.org/10.1002/chem.201302354
Publikováno v:
The FASEB Journal. 29
Protein folding energy landscapes have been driven by evolution to minimize the energetic and topological frustration experienced during the folding reaction. Small 2 state folders, whose folding r...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4864919753899263f2a9aaf41fc1744b
https://doi.org/10.1096/fasebj.29.1_supplement.882.12
https://doi.org/10.1096/fasebj.29.1_supplement.882.12
Publikováno v:
Journal of the American Chemical Society. 135(5)
Recent molecular dynamics simulations have suggested important roles for nanoscale dewetting in the stability, function, and folding dynamics of proteins. Using a synergistic simulation-experimental approach on the αTS TIM barrel protein, we validat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4300699e31e8cc6547a1587a3f3cbd
https://pubmed.ncbi.nlm.nih.gov/23293932
https://pubmed.ncbi.nlm.nih.gov/23293932