Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kevin T Vaughan"'
Autor:
Zachary T Wehrmann, Tyler W Hulett, Kara L Huegel, Kevin T Vaughan, Olaf Wiest, Paul Helquist, Holly Goodson
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48561 (2012)
Niemann-Pick Type C disease (NPC) is a lethal, autosomal recessive disorder caused by mutations in the NPC1 and NPC2 cholesterol transport proteins. NPC's hallmark symptoms include an accumulation of unesterified cholesterol and other lipids in the l
Externí odkaz:
https://doaj.org/article/165bb543057e4b75a22d6b5eae40c27f
Autor:
Felicity R. Sterling, Jon D'Amico, Alexandria M. Brumfield, Kara L. Huegel, Patricia S. Vaughan, Kathryn Morris, Shelby Schwarz, Michelle V. Joyce, Bill Boggess, Matthew M. Champion, Kevin Maciuba, Philip Allen, Eric Marasco, Grant Koch, Peter Gonzalez, Shannon Hodges, Shannon Leahy, Erica Gerstbauer, Edward H. Hinchcliffe, Kevin T. Vaughan
Publikováno v:
Journal of Cell Science. 136
The pathological accumulation of cholesterol is a signature feature of Niemann–Pick type C (NPC) disease, in which excessive lipid levels induce Purkinje cell death in the cerebellum. NPC1 encodes a lysosomal cholesterol-binding protein, and mutati
Autor:
Charles A. Day, Florina Grigore, Faruck L. Hakkim, Alyssa Langfald, Sela Fadness, Paiton Schwab, Leslie Sepaniac, Jason Stumpff, David J. Daniels, Kevin T. Vaughan, James P. Robinson, Edward H. Hinchcliffe
During the cell cycle, differential phosphorylation of select histone H3 serine/threonine residues regulates chromatin structure, necessary for both dynamic transcriptional control and proper chromosome segregation1-2. Histone H3.3 contains a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f3eecf7575dbd2d6284e2314625548
https://doi.org/10.1101/2022.05.27.493485
https://doi.org/10.1101/2022.05.27.493485
Autor:
Dana F. DeSantis, Kevin T. Vaughan, Cody J. Smith, Nina L. Kikel-Coury, Isabel A. Correia, Felicity Sterling, Gulberk Ozcebe, Pinar Zorlutuna, Jacob P. Brandt, Michael R. O’Dea
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
PLoS Biology
PLoS Biology, Vol 19, Iss 11, p e3001444 (2021)
PLoS Biology
PLoS Biology, Vol 19, Iss 11, p e3001444 (2021)
Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, an
Autor:
Alyssa Langfald, Florina Grigore, James P. Robinson, Charles A. Day, Edward H. Hinchcliffe, Jason Stumpff, Leslie A. Sepaniac, Kevin T. Vaughan
Publikováno v:
Neuro Oncol
Pediatric midline gliomas – including DIPG – are lethal brain tumors in children, with poor prognosis and limited treatment options that provide only short-term benefits. The majority have a lysine-to-methionine substitution at residue 27 (H3K27M
Autor:
Edward H. Hinchcliffe, Alyssa Langfald, Kevin T. Vaughan, Charles A. Day, Leslie A. Sepaniac, Jason Stumpff, Tatyana A. Zykova, James P. Robinson, Sela Fadness, Zigang Dong
Publikováno v:
Neuro Oncol
Diffuse intrinsic pontine glioma (DIPG) carries a signature mutation in histone H3.3 (K27M) that induces epigenetic reprogramming via suppressed Lys27 triple methylation (K27me3). H3.3 has a Ser at position 31, which is adjacent to the K27M DIPG muta
Autor:
Alyssa Langfald, Kevin T. Vaughan, Leslie A. Sepaniac, James P. Robinson, Edward H. Hinchcliffe, Charles A. Day, Sela Fadness, Florina Grigore, Jason Stumpff
Publikováno v:
Neuro-Oncology
Diffuse midline gliomas with the H3.3 K27M mutation are lethal brain tumors in children. H3 K27M causes global loss of Lys27 triple methylation (Lys27me3), inducing epigenetic reprograming. Here we show that H3.3 K27M also causes decreased H3.3 Ser31
Autor:
Adam W. Avery, Gordon K. Chan, Anudariya B. Dean, Paurav B. Desai, Ian R. Gibbons, Thomas S. Hays, Edward H. Hinchcliffe, Yuqing Hou, Emily L. Hunter, Juyeon Hwang, Takashi Ishikawa, Rupam Jha, Ritsu Kamiya, Stephanie A. Ketcham, K. Kevin Pfister, Stephen M. King, Cody W. Lewis, Min-Gang Li, Richard J. McKenney, David R. Mitchell, Amanda L. Neisch, Mary E. Porter, Winfield S. Sale, Trina A. Schroer, Chikako Shingyoji, Thomas Surrey, Noriko Ueki, Richard B. Vallee, Kevin T. Vaughan, Ken-ichi Wakabayashi, Bill Wickstead, Maureen Wirschell, George B. Witman, Xin Xiang, Toshiki Yagi, Lionel Berthoux, Andrew P. Carter, Amrita Dawn, David J. Doobin, Mike Fainzilber, Elizabeth M.C. Fisher, Ken’ya Furuta, Veikko F. Geyer, Steven P. Gross, William O. Hancock, Kent L. Hill, Erika L.F. Holzbaur, Jonathon Howard, Simon Imhof, Kazuo Inaba, Frank Jülicher, Tarun M. Kapoor, Sandip Koley, Christine M. Lightcap, Niki T. Loges, Miroslav P. Milev, Hannah M. Mitchison, Armen J. Moughamian, Andrew J. Mouland, Kazuhiro Oiwa, Heymut Omran, Stephen H. Pilder, Michael Price, Babu J.N. Reddy, Hitoshi Sakakibara, Pablo Sartori, Helgo Schmidt, Miriam Schmidts, Amanda E. Siglin, Joseph H. Sisson, Jonathan B. Steinman, George T. Shubeita, Marco Terenzio, John B. Vincent, John C. Williams, Fan Yang, Xaojian Yao, Ahmet Yildiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4fc3e596df0e76a7b86db619d9e001
https://doi.org/10.1016/b978-0-12-809471-6.01002-0
https://doi.org/10.1016/b978-0-12-809471-6.01002-0
Autor:
Jessica E. Hornick, Christopher C. Mader, Edward H. Hinchcliffe, Kevin T. Vaughan, Sidney L. Shaw, Cydney C. Bagne, Emily K. Tribble
Publikováno v:
Current Biology. 21(7):598-605
SummaryThe role of centrosomes and centrioles during mitotic spindle assembly in vertebrates remains controversial. In cell-free extracts and experimentally derived acentrosomal cells, randomly oriented microtubules (MTs) self-organize around mitotic
Autor:
Jason R. Bader, Edward H. Hinchcliffe, Maurice Raycroft, Sinji B.F. Tauhata, Jacqueline Whyte, K. Kevin Pfister, Jessica E. Hornick, Patricia S. Vaughan, William S. Lane, Gordon K. Chan, Kevin T. Vaughan
Publikováno v:
The Journal of Cell Biology
Cytoplasmic dynein functions at several sites during mitosis; however, the basis of targeting to each site remains unclear. Tandem mass spectrometry analysis of mitotic dynein revealed a phosphorylation site in the dynein intermediate chains (ICs) th